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教室紹介

診療・研究内容

(1)虚血グループ

虚血グループ
虚血グループでは年間約700例の心臓カテーテル検査と約300例の冠動脈インターベンションを施行しています。東北大学病院救急救命センターと密接に連携し、急性冠症候群の診断・治療を行う体制も整えています。また虚血性心疾患の病態解明のための臨床研究ならびに重症例に対する先進医療(体外衝撃波治療)にも積極的に取り組んでいます。

当グループにおけるカテーテル総数とPCI数の推移

1. 冠攣縮性狭心症の病態解明

図1冠攣縮は、異型狭心症のみならず、その他の全ての種類の狭心症や急性心筋梗塞症、心臓性突然死などの虚血性心疾患全般の発症に重要な役割を果たしています。特に日本人では虚血性心臓病の成因に極めて重要であると考えられることから、冠攣縮に対する基礎的・臨床的見地から研究を行っております。東北大学、熊本大学(小川久雄教授)を中心に、全国68施設にて「冠攣縮研究会」を組織し全国規模での臨床研究を進めております(図1)。基礎的には、冠動脈攣縮の分子機構にRho-kinaseの活性化が深く関与していることが明らかにされており、今後の応用・展開が期待されています。

2. 冠動脈インターベンションに関するEBM(根拠に基づいた医療)構築

図2病態に応じた治療法の選択、根拠に基づいた医療が求められています。虚血性心疾患の治療法の一つに冠動脈インターベンションがあり、その中でもステント治療は主体となるものです。ステントには現在ベアメタルステント(BMS)と薬物溶出性ステント(DES)の2種類があり、各々の利点・欠点を科学的に評価し、病態に応じた選択を行うことを目指しています(図2)。本グループではDESとBMSそれぞれの植え込み至適病変と治療効果判定を血管内超音波(IVUS)や定量的冠動脈造影(QCA)を用いて行っております。また、治療根拠として心筋虚血の評価は重要です。核磁気共鳴法(MRI)を用いた、心筋虚血や心筋viabilityの評価に関する研究も行っております。

3. 院外心停止例の病態解明

院外心停止例は、年間3〜5万件と推定され、交通事故死亡者数の3〜4倍に及ぶ。近年市民よる心肺蘇生実施やAED(自動体外式除細動器)の普及により救命率が向上している。なぜ心停止に陥ったか?その病態解明は極めて重要である。当科では冠動脈や心筋に器質的な異常が認められない場合、冠攣縮誘発(アセチルコリン負荷試験)・心室細動誘発(電気生理学的検査)を追加し機能的評価を併せて行っている。

図3:院外心停止例の病態解明

図3

4. 重症虚血性心疾患に対する低出力体外衝撃波治療

当科では、衝撃波を用いた新しい血管新生療法の臨床試験を行っています。この治療法は、低出力の衝撃波を体外から虚血心筋に照射することにより血管新生を促し、心筋虚血を改善させる非侵襲的な治療法です。大学倫理委員会の承認を得て、2005年11月から重症狭心症症例を対象に(図4)、また2007年2月から急性心筋梗塞症例を対象に(図5)、臨床試験が進行中です。
>>「重症虚血性疾患の衝撃波治療」のサイトはこちらから

図4:体外衝撃波治療による心筋血流の改善

図4

図5:図5

5. 重症虚血性心疾患に対する低出力パルス波超音波治療

当科では、超音波を用いた新しい血管新生療法の治験を行っています。この治療法は、一つのプローブで診断と治療の両方が可能であること、組織を損傷する可能性が少ないこと、診断用装置がすでに世界中に普及していることなどから、その有効性が確認できれば汎用性は極めて高いものと考えられます。大学倫理委員会の承認を得て、2013年12月から重症狭心症症例を対象に、東北大学病院を含む全国10施設で医師主導治験が進行中です(図6)。
>>「超音波治療(超音波血管新生療法)」のサイトはこちらから

図6:狭心症超音波治験の治験実施施設
図6

主な研究業績 (2005年以降)
2017年
  1. Kagaya Y, Ito K, Takahashi J, Matsumoto Y, Takashi Shiroto T, Tsuburaya R, Kikuchi Y, Hao K, Nishimiya K, Shindo T, Ogata T, Kurosawa R, Eguchi K, Monma Y, Ichijo S, Hatanaka K, Miyata S, Shimokawa H. Low-energy cardiac shock wave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction. -A first-in-human study- Coron Art Dis. (in press)
  2. Nishimiya K, Matsumoto Y, Wang H, Piao Z, Ohyama K, Uzuka H, Hao K, Tsuburaya R, Takahashi J, Ito K, Shimokawa H. Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge -An optical coherence tomography study- Int J Cardiol. (in press)
  3. Ogata T, Ito K, Shindo T, Hatanaka K, Eguchi K, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Taki H, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice.PLOS ONE. 12:e0185555,2017.PDF
  4. Ito K, Shindo T, Shimokawa H. Low-energy extracorporeal shock wave therapy. In: Higashi Y, Murohara T (eds.). Therapeutic Angiogenesis. pp. 177-190. Springer Nature, Singapore, 2017.PDF
  5. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, M, Glynn RJ; the CANTOS Trial Group. Anti-Inflammatory therapy with canakinumab for atherosclerotic disease. New Engl J Med. DOI: 10.1056/NEJMoa1707914.PDF
  6. Ong P, Camici PG, Beltrame J, Crea F, Shimokawa H, Sechtem U, Kaski JC, Merz CNB. International standardization of diagnostic criteria for microvascular angina. Int J Cardiol. (in press)
  7. Uzuka H, Matsumoto Y, Nishimiya K, Ohyama K, Suzuki H, Amamizu H, Morosawa S, Hirano M, Shindo T, Kikuchi Y, Hao K, Shiroto T, Ito K, Takahashi J, Fukuda K, Miyata S, Funaki Y, Ishibashi-Ueda H, Yasuda S, Shimokawa H. Renal denervation suppresses coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo through the kidney-brain-heart axis. Arterioscler Thromb Vasc Biol. 37:1869-1880,2017.PDF
  8. Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Morosawa S, Hirano M, Watabe H, Funaki Y, Miyata S, Takahashi J, Ito K, Shimokawa H. Association of coronary perivascular adipose tissue inflammation and DES-induced coronary hyperconstricting responses in pigs -FDG PET imaging study- Arterioscler Thromb Vasc Biol. 37:1757-1764,2017.PDF
  9. Godo S, Shimokawa H. Recent highlights of ATVB: Endothelial functions. Arterioscler Thromb Vasc Biol. 37:e108-e114,2017.PDF
  10. Nihei T, Yamamoto Y, Kudo S, Hanawa K, Hasebe Y, Takagi Y, Minatoya Y, Sugi M, Shimokawa H. Impact of the intracoronary Rendezvous technique on coronary angioplasty for chronic total occlusion. Cardiovasc Interv Ther. (in press)PDF
  11. Cui Y, Hao K, Takahashi J, Miyata S, Shindo T, Nishimiya K, Kikuchi Y, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H. Age-specific trends in the incidence and in-hospital mortality of acute myocardial infarction over 30 years in Japan - Report from the Miyagi AMI Registry Study- Circ J. 81:520-528,2017.PDF
  12. Ohtsuki T, Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Aoki T, Tatebe S, Sugimura K, Takahashi J, Miyata S, Shimokawa H. Prognostic impacts of plasma levels of cyclophilin A in patients with coronary artery disease. Arterioscler Thromb Vasc Biolol. 37:685-693,2017.PDF
  13. Godo S, Shimokawa H. Divergent roles of endothelial nitric oxide synthases system in maintaining cardiovascular homeostasis. Free Radical Biology & Medicine. 109:4-10,2017.PDF
  14. Crea F, Merz CNB, Beltrame JF, Kaski JC, Ogawa H, Ong P, Sechtem U, Shimokawa H, Camici P: COVADIS Group. The parallel tales of microvascular angina and heart failure with preserved ejection fraction: a paradigm shift. Eur Heart J. 38:473-477,2017.PDF
  15. Odaka Y, Takahashi J, Tsuburaya R, Nishimiya K, Hao K, Matsumoto Y, Ito K, Sakata Y, Miyata S, Manita D, Hirowatari Y, Shimokawa H. Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries. Eur Heart J. 38:489-496,2017.PDF
  16. Ohyama K, Matsumoto Y, Shimokawa H. Impact of epicardial adipose tissue volume quantified by non-contrast electrocardiogram-gated computed tomography on ergonovine-induced epicardial coronary artery spasm. (Letter to the Editor) Int J Cardiol. 229:40,2017.PDF
  17. Beltrame J, Crea F, Kaski JC, Ogawa H, Ong P, Sechtem U, Shimokawa H, Merz CNB; COVADIS Group. International standardization of diagnostic criteria for vasospastic angina. Eur Heart J. doi:10.1093/eurheartj/ehv351.PDF
2016年
  1. Beltrame JF, Crea F, Kaski JC, Ogawa H, Ong P, Sechtem U, Shimokawa H, Merz CNB, the COVADIS Group. The who, what, why, when, how and where of vasospastic angina. Circ J. 80:289-298,2016.PubMed
  2. Komatsu M, Takahashi J, Fukuda K, Takagi Y, Shiroto T, Nakano M, Kondo M, Tsuburaya R, Hao K, Nishimiya K, Nihei T, Matsumoto Y, Ito K, Sakata Y, Miyata S, Shimokawa H. Usefulness of Testing for Coronary Artery Spasm and Programmed Ventricular Stimulation in Survivors of Out-of-Hospital Cardiac Arrest. Circ Arrhythm Electrophysiol. 9:doi:10.1161/CIRCEP.115.003798,2016.PDF
  3. Kozu K, Suzuki H, Nishiyama S, Yaoita N, Yamamoto S, Tatebe S, Miura M, Aoki T, Hao K, Matsumoto Y, Sugimura K, Aoki M, Shimokawa H. Multiple sclerosis lesion in the medulla oblongata in a patient with takotsubo cardiomyopathy. Int J Cardiol. 8:980-981,2016.PubMed
  4. Merz CN, Beltrame J, Camici P, Crea F, Kaski JC, Ogawa H, Peter P, Sechtem U, Shimokawa H. A shocking development in a young male athlete with chest pain (Letter to the Editor). Circulation. 133:756-763,2016.PubMed
  5. Nishimiya K, Matsumoto Y, Takahashi J, Uzuka H, Wang H, Tsuburaya R, Hao K, Ohyama K, Odaka Y, Miyata S, Ito K, Shimokawa H. Enhanced adventitial vasa vasorum formation in patients with vasospastic angina -Assessment with optical frequency domain imaging- J Am Coll Cardiol. 67:598-600,2016. PubMed
  6. Nishimiya K, Matsumoto Y, Uzuka H, Ohyama K, Hao K, Tsuburaya R, Shiroto T, Takahashi J, Ito K, Shimokawa H. Focal vasa vasorum formation in patients with focal coronary vasospasm -An optical frequency domain imaging study- Circ J. 80:2252-2254,2016.PDF
  7. Ohyama K, Matsumoto Y, Nishimiya K, Hao K, Tsuburaya R, Ota H, Amamizu H, Uzuka H, Takahashi J, Ito K, Shimokawa H. Increased coronary perivascular adipose tissue volume in patients with vasospastic angina. Circ J. 80:1653-1656,2016.PDF
  8. Shimokawa H, Sunamura S, Satoh K. RhoA/Rho-kinase in the cardiovascular system. Circ Res. 118:352-366,2016.PDF
  9. Suda A, Namiuchi S, Kawaguchi T, Nihei T, Takii T, Saji K, Sugie T, Kato A, Shimokawa H. A simple and rapid method for identification of lesions at high risk for the no-reflow phenomenon immediately before elective coronary stent implantation. Heart Vessels. 31:1904-1914,2016.PubMed
  10. Tsuburaya R, Takahashi J, Nakamura A, Nozaki E, Sugi M, Yamamoto Y, Hiramoto T, Horiguchi S, Inoue K, Goto T, Kato A, Shinozaki T, Ishida E, Miyata S, Yasuda S, Shimokawa H; the NOVEL Investigators. Beneficial effects of long-acting nifedipine on coronary vasomotion abnormalities after drug-eluting stent implantation. -The NOVEL Study- Eur Heart J. 37:2713-2721,2016.PubMed
2015年
  1. Ito K, Shimokawa H. The future of non-invasive angiogenic therapy using acoustic waves. Circ J. 79:1906-1907,2015. PubMed
  2. Nishimiya K, Matsumoto Y, Uzuka H, Oyama K, Tanaka A, Taruya A, Ogata T, Hirano M, Shindo T, Hanawa K, Hasebe Y, Hao K, Tsuburaya R, Takahashi J, Miyata S, Ito K, Akasaka T, Shimokawa H. Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans -A validation study- Circ J. 79:1323-1331,2015.PDF
  3. Onose T, Nochioka K, Sakata Y, Miura M, Tadaki S, Ushigome R, Yamauchi T, Sato K, Tsuji K, Abe R, Miyata S, Takahashi J, Shimokawa H. Predictors and prognostic impact of post-traumatic stress disorder after the Great East Japan Earthquake in patients with cardiovascular disease -- Report from the CHART-2 Study -- Circ J. 79:664-667,2015.PDF
  4. Satoh K. Cyclophilin A in cardiovascular homeostasis and diseases. Tohoku J Exp Med. 235:1-15,2015.PubMed
  5. Shimokawa H, Satoh K. 2015 ATVB Plenary lecture: Translational research on Rho-kinase in cardiovascular medicine. Arterioscler Thromb Vasc Biol. 35:1756-1769,2015.PDF
  6. Shimokawa H, Satoh K. Light and dark of reactive oxygen species for vascular function. J Cardiovasc Pharmacol. 65:412-418,2015.PubMed
  7. Takahashi J, Shimokawa H. Earthquake, cardiovascular diseases and implications for public health. In Watson RR, Tabor JA, Ehiri JE, Preedy (eds.), Handbook of Public Health in Natural Disasters, pp.309-333, Wageningen Academic Publishers, The Netherlands, 2015.
  8. Takahashi J, Nihei T, Takagi Y, Miyata S, Odaka Y, Tsunoda R, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Momomura S, Yasuda S, Ogawa H, Shimokawa H, on behalf of the Japanese Coronary Spasm Association. Prognostic impact of chronic nitrate therapy in patients with vasospastic angina -Multicenter registry study of the Japanese Coronary Spasm Association- Eur Heart J. 36:228-237,2015.PubMed
2014年
  1. Hao K, Takahashi J, Aoki T, Miyata S, Ito K, Sakata Y, Shimokawa H. Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake Disaster. Intn'l J Cardiol. 177:569-572,2014.PubMed
  2. Hao K, Takahashi J, Ito K, Miyata S, Sakata Y, Nihei T, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Yasuda S, Shimokawa H. Emergency care of acute myocardial infarction and the Great East Japan Earthquake Disaster -Report From the Miyagi AMI Registry Study- Circ J. 78:634-643,2014.PDF
  3. Nihei T, Takahashi J, Tsuburaya R, Ito Y, Shiroto T, Hao K, Takagi Y, Matsumoto Y, Nakayama M, Miyata S, Sakata Y, Ito K, Shimokawa H. Circadian variation of rho-kinase activity in circulating leukocytes of patients with vasospastic angina. Circ J. 78:1183-1190,2014.PDF
  4. Sakata Y, Shimokawa H. Ischemic heart disease. In: Wakabayashi I, Groschner K (eds), Interdisciplinary Concepts of Cardiovascular Health. pp.1-17. Springer, Wien, Austria. 2014.
  5. Satoh K, Shimokawa H. High-sensitivity C-reactive protein: Still need for next-generation biomarkers for remote future cardiovascular events. Eur Heart J. 35:1776-1778,2014. (Editorial)PubMed
  6. Shimokawa H. 2014 William Harvey Lecture. Importance of coronary vasomotion abnormalities -From bench to bedside- Eur Heart J. 35:3180-3193,2014.PubMed
  7. Shimokawa H, Satoh K. Recent Highlights of ATVB: Vascular function. Arteriosclr Thromb Vasc Biol. 34:2359-2362,2014.
  8. Suzuki H, Matsumoto Y, Kaneta T, Sugimura K, Takahashi J, Fukumoto Y, Takahashi S, Shimokawa H. Evidence for brain activation in patients with takotsubo cardiomyopathy. Circ J. 78:256-258,2014.PDF
  9. Yamaya S, Ozawa H, Kanno H, Kishimoto KN, Sekiguchi A, Tateda S, Yahata K, Ito K, Shimokawa H, Itoi E. Low-energy extracorporeal shock wave therapy promotes VEGF expression and neuroprotection and improves locomotor recovery after spinal cord injury. J Neurosurg. 121:1514-1525,2014.PubMed
2013年
  1. Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T, Sukegawa H, Ogata K, Shimokawa H. Effect of the Great East Japan Earthquake Disaster on cardiovascular diseases -A report from the 10 hospitals in the Disaster area- Circ J. 77:490-493,2013.PDF
  2. Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu F, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Park JE, Tada-Oikawa S, Kitajima H, Matsubara T, Sunagawa K, Shimokawa H, Kimura A, Lee JY, Murohara T, Inoue I, Yokota M. Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circulation: Cardiovascular Genetics. 6:569-578,2013.PubMed
  3. Kawana A, Takahashi J, Takagi Y, Yasuda S, Sakata Y, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Gender differences in clinical characteristics and outcomes of patients with vasospastic angina -A report from the Japanese Coronary Spasm Association- Circ J. 77:1267-1274,2013.PDF
  4. Sakata Y, Shimokawa H. Saturated fatty acid intake and cardiovascular risk. Eur Heart J. 34:1178-1180,2013.PubMed
  5. Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H. Plasma cyclophilin A is a novel biomarker for coronary artery disease. Circ J. 77:447-455,2013.PDF
  6. Takagi Y, Takahashi J, Yasuda S, Miyata S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H, on Behalf of the Japanese Coronary Spasm Association. Prognostic stratification of patients with vasospastic angina - A comprehensive clinical risk score developed by the Japanese Coronary Spasm Association - J Am Coll Cardiol. 62:1144-1153,2013.PubMed
  7. Takagi Y, Yasuda S, Takahashi J, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact -Multicenter registry study of the Japanese Coronary Spasm Association- Eur Heart J. 34:258-267,2013.PubMed
  8. Yasuda S, Shimokawa H. The Pathogenesis of Vasospastic Angina. In: Kaski JC, Eslick GD, Bairey Merz CN (eds.), Chest Pain with Normal Coronary Arteries, pp.91-99. Springer-Verlag, London, UK, 2013.
2012年
  1. Aizawa K, Yasuda S, Takahashi J, Takii T, Kikuchi Y, Tsuburaya R, Ito Y, Ito K, Nakayama M, Takeda M, Shimokawa H. Involvement of Rho-kinase activation in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in patients with coronary artery disease. Circ J. 76:2552-2560,2012.PDF
  2. Aoki T, Fukumoto Y, Yasuda S, Sakata Y, Ito K, Takahashi J, Miyata S, Tsuji I, Shimokawa H. The Great East Japan Earthquake Disaster and cardiovascular diseases. Eur Heart J. 33:2796-2803,2012.PubMed
  3. Hao K, Yasuda S, Takii T, Ito Y, Takahashi J, Ito K, Nakayama M, Shiba N, Fukumoto Y, Shimokawa H. Urbanization, life-style changes and incidence and in-hospital mortality from acute myocardial infarction in Japan -Report from the MIYAGI-AMI Registry- Circ J. 76:1136-1144,2012.PDF
  4. Kromhout D, Yasuda S, Geleijnse JM, Shimokawa H. Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work? Eur Heart J. 33:436-443,2012.PubMed
  5. Nihei T, Takahashi J, Kikuchi Y, Takagi Y, Hao K, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H. Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake. Circ J. 76:2892-2894,2012.PDF
  6. Nochioka K, Tanaka S, Miura M, Zhulanqiqige DE, Fukumoto Y, Shiba N, Shimokawa H. Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans. Circ J. 76:2023-2030,2012.PDF
  7. Satoh K, Fukumoto Y, Nakano M, Kagaya Y, Shimokawa H. Emergence of the erythropoietin/erythropoietin receptor system as a novel cardiovascular therapeutic target. J Cardiovasc Pharmacol. 58:570-574,2012.PubMed
  8. Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada Y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, Watanabe T, Sato A, Shimokawa H, Satomi S. Extracorporeal shock wave therapy ameliorates walking ability of patients with peripheral artery disease and intermittent claudication. Circ J. 76:1486-1493,2012.PubMed
  9. Takeda M, Shiba N, Takahashi J, Shimokawa H. A case report of very late stent thrombosis with peri-stent coronary artery aneurysm and stent-related coronary vasospasm: Insight to the mechanisms of sirolimus-eluting stent failure. Cardiovass Interven Therapeutics. 28:272-278,2013.PubMed
  10. Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H. Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway. Eur Heart J. 33:791-799,2012.PubMed
2011年
  1. Gao JY, Yasuda S, Tsuburaya R, Ito Y, Shiroto T, Hao K, Aizawa K, Kikuchi Y, Ito K, Shimokawa H. Long-term treatment with eicosapentaenoic acid ameliorates myocardial ischemia-reperfusion injury in pigs in vivo -Involvement of Rho-kinase pathway inhibition- Circ J. 75:1843-1851,2011.PubMed
  2. Ito K, Fukumoto Y, Shimokawa H. Extracorporeal shock wave therapy for ischemic cardiovascular disorders. Am J Cardiovasc Drugs. 11:295-302,2011.PubMed
  3. Kikuchi Y, Yasuda S, Aizawa K, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H. Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment. J Am Coll Cardiol. 58:1231-1237,2011.PubMed
  4. Nakayama M, Osaki S, Shimokawa H. Validation of the mortality risk stratification models for cardiovascular disease. Am J Cardiol. 108:391-396,2011. PubMed
  5. Satoh K, Berk BC, Shimokawa H. Vascular-derived reactive oxygen species for homeostasis and diseases. Nitric Oxide. 25:211-215,2011. (Review)PubMed
  6. Satoh K, Fukumoto Y, Shimokawa H. Rho-kinase: Important new therapeutic target in cardiovascular diseases. Am J Physiol. 301:287-296,2011.PubMed
  7. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest. -Multicenter registry study of the Japanese Coronary Spasm Association- Circulation Arrhythmia & Electrophysiology. 4:295-302,2011.PubMed
  8. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Gao JY, Ito K, Shimokawa H. Eicosapentaenoic acid reduces ischemic ventricular fibrillation via altering monophasic action potential in pigs. J Mol Cell Cardiol. 51:329-336,2011. PubMed
2010年
  1. Ito K, Kagaya Y, Shimokawa H. Thyroid hormone and chronically unloaded hearts. Vasc Pharmacol. 52:138-141,2010.PubMed
  2. Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi GJ, Takeda M, Fukumoto Y, Yasuda S, Shimokawa H. Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo. Coron Artery Dis. 21:304-311,2010.PubMed
  3. Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I, Shimokawa H. Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. Circ J. 74:589-591,2010.PubMed
  4. Shimokawa H, Ito K. Extracorporeal cardiac shock wave therapy for ischemic heart disease. In: Achim M. Loske (ed.), New Trends in Shock Wave Applications to Medicine and Biotechnology, Research Signpost, India, 211-224,2010.
  5. Takagi Y, Sugi M, Hanawa K, Shimokawa H. Successful recanalization of chronic total occlusion using retrograde approach in a patient with acute coronary syndrome due to aortosaphenous vein graft occlusion. JC Cases. 1:e112-115,2010.
  6. Takii T, Yasuda S, Takahashi J, Ito K, Shiba N, Shirato K, Shimokawa H; MIYAGI-AMI Study Investigators. Trends in acute myocardial infarction incidence and mortality over 30 years in Japan: report from the MIYAGI-AMI Registry Study. Circ J. 74:93-100,2010.PubMed
  7. Yasuda S, Shimokawa H. Potential usefulness of fish oil in the primary prevention of acute coronary syndrome. Eur Heart J. 31:15-16,2010.PubMed
2009年
  1. Ito K, Fukumoto Y, Shimokawa H. Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy. Tohoku J Exp Med. 219:1-9,2009.PubMed
  2. Shiroto T, Yasuda S, Tsuburaya R, Ito Y, Takahashi J, Ito K, Ishibashi-Ueda H, Shimokawa H. Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo. J Am Coll Cardiol. 54:2321-2329,2009.PubMed
  3. Takagi Y, Yasuda S, Takahashi J, Takeda M, Nakayama M, Ito K, Hirose M, Wakayama Y, Fukuda K, Shimokawa H. Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest. Circ J. 73:767-769,2009.PubMed
  4. Yasuda S, Shimokawa H. Acute myocardial infarction: the enduring challenge for cardiac protection and survival. Circ J. 73:2000-2008,2009.PubMed
2008年
  1. Fukumoto Y, Yasuda S, Ito A, Shimokawa H. Prognostic effects of benidipine in patients with vasospastic angina:comparison with diltiazem and amlodipine. J Cardiovasc Pharmacol. 51:253-257,2008.PubMed
  2. Kokusho Y, Komaru T, Takeda S, Takahashi K, Koshida R, Shirato K, Shimokawa H. Hydrogen peroxide derived from beating heart mediates coronary microvascular dilation during tachycardia. Arterioscler Thromb Vasc Biol. 27:1057-1063,2008.PubMed
  3. Oi K, Fukumoto Y, Ito K, Uwatoku T, Abe K, Hizume T, Shimokawa H. Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits. Tohoku J Exp Med. 214:151-158,2008.PubMed
  4. Shimokawa H, Ito K, Fukumoto Y, Yasuda S. Extracorporeal cardiac shock wave therapy for ischemic heart disease. Shock Waves 17:449-455,2008.
  5. Shimokawa H, Yasuda S. Myocardial ischemia: Current concepts and future perspectives. J Cardiol. 52:67-78,2008.PubMed
  6. Tada T, Nawata J, Wang H, Onoue N, Zhulanqiqige D, Ito K, Sugimura K, Fukumoto Y, Shimokawa H. Enhanced pulsatile pressure accelerates vascular smooth muscle migration: implications for atherogenesis of hypertension.Cardiovasc Res. 17:449-455,2008.PubMed
2007年
  1. Asaumi Y, Kagaya Y, Takeda M, Yamaguchi N, Tada H, Ito K, Ohta J, Shiroto T, Shirato K, Minegishi N, Shimokawa H. Protective role of endogenous erythropoietin system in nonhematopoietic cells against pressure overload-induced left ventricular dysfunction in mice. Circulation. 115:2022-2032,2007.PubMed
  2. Minatoya Y, Ito K, Kagaya Y, Asaumi Y, Takeda M, Nakayama M, Takahashi J, Iguchi A, Shirato K, Shimokawa H. Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats. Acta Physiol (Oxf). 189:221-231,2007.PubMed
  3. Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K, Shimokawa H. Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. Coron Artery Dis. 18:397-404,2007.PubMed
  4. Yasuda S, Ikuta K, Uwatoku T, Oi K, Abe K, Hyodo F, Yoshimitsu K, Sugimura K, Utsumi H, Katayama Y, Shimokawa H. In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice. J Vasc Res. 45:123-128,2007.PubMed
2006年
  1. Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H, Karibe A, Minegishi N, Suzuki N, Yamamoto M, Ono M, Watanabe J, Shirato K, Ishii N, Sugamura K, Shimokawa H. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation. 113:1442-1450,2006.PubMed
  2. Tada H, Kagaya Y, Takeda M, Ohta J, Asaumi Y, Satoh K, Ito K, Karibe A, Shirato K, Minegishi N, Shimokawa H. Endogenous erythropoietin system in non-hematopoietic lineage cells plays a protective role in myocardial ischemia/reperfusion. Cardiovasc Res. 71:466-477,2006.PubMed
2005年
  1. Namiuchi S, Kagaya Y, Ohta J, Shiba N, Sugi M, Oikawa M, Kunii H, Yamao H, Komatsu N, Yui M, Tada H, Sakuma M, Watanabe J, Ichihara T, Shirato K. High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention. J Am Coll Cardiol. 45:1406-1412,2005.PubMed

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