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教室紹介

研究業績

国際学会

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2016年(*招待講演)
2016年12月3日, Korean ACHD Symposium 2016

<Lunch symposium>

  1. *Tatebe S. New drugs for PHT; Japanese experiecne of Macitentan.
2016年11月12〜16日, American Heart Association (AHA) Scientific Sessions (New Orleans , USA)

    <Oral presentation>

  1. Aoki T, Sugimura K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H. Safety of Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension -Detail Analyses of Procedure Related Complications-
  2. Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Ohtsuki T, Kozu K, Numano K, Sugimura K, Tatebe S, Aoki T, Suzuki K, Yaoita N, Shimokawa H. A Disintegrin and Metalloproteinase With Thrombospondin Motifs 8 Downregulates AMP-activated Protein Kinase and Promotes Matrix Metalloproteinases Activation and Pulmonary Hypertension (Travel Award受賞)
  3. Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Sunamura S, Nogi M, Otsuki T, Numano K, Elias-Al-Mamun M, Mohammad Abdul Hai Siddique, Tatebe S, Aoki T, Sugimura K, John Morser and Shimokawa H. Thrombin Activatable Fibrinolysis Inhibitor Promotes Development of Chronic Thromboembolic Pulmonary Hypertension -A Possible Novel Therapeutic Target- (Travel Award受賞)
  4. Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Morosawa S, Hirano M. Evidence for Involvement of Inflammatory Changes of Perivascular Adipose Tissue in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Drug-Eluting Stent in Pigs in vivo -Impact of Fluorodeoxyglucose Positron Emission Tomography Imaging- (Travel Award受賞)
  5. Tanaka S, Sato S, Ikumi Y, Ito A, Saito H, Godo S, Shimokawa H. Roles of Endothelium-Dependent Hyperpolarization in Pulmonary Microcirculation in Mice
  6. <Poster presentations>

  7. Tatebe S, Sugimura K, Aoki T, Yamamoto S, Yaoita N, Kozu K, Sato H, Satoh K, Shimokawa H. Long-term Efficacy of Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension
  8. Godo S, Tanaka S, Ito A, Ikumi Y, Shimokawa H. Physiological Balance Between Nitric Oxide and Endothelium-dependent Hyperpolarization Plays Important Roles in Microvascular Homeostasis in Mice
  9. Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Eguchi K, Kagaya Y, Hanawa K, Aizawa K, Shiroto T, Miyata S, Kanai H, Shimokawa H. Molecular Mechanism for Low-intensity Pulsed Ultrasound-induced Angiogenesis (Travel Award受賞)
  10. Shindo T, Ito K, Hatanaka K, Ogata T, Kurosawa R, Kagaya Y, Eguchi K, Shimokawa H. Molecular Mechanisms of Angiogenic Effects of Low-energy Shock Wave Therapy: Involvement of Mechanotransduction Pathways
  11. Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka N, Takahashi J, Shiroto T, Miyata S, Shimokawa H. Prognostic Impact of and Risk Score for the Onset of Atrial Fibrillation in Patients at High Risk for Heart Failure -A Report From the CHART-2 Study-
  12. Tsuji K, Sakata Y, Miura M, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Nochioka K, Takahashi J, Miyata S, Shimokawa H. Unique Clinical Features of Patients With Heart Failure With Preserved Ejection Fraction -Insights From the CHART-2 Study-
  13. Hirano M, Yamamoto H, Hasebe Y, Fukuda K, Morosawa S, Amamizu H, Ohyama K, Uzuka H, Takayama K, Shimokawa H. Development of a Novel Shock Wave Catheter Ablation System -The Validation Study in Pigs in vivo-
  14. Uzuka H, Matsumoto Y, Ohyama K, Nishimiya K, Amamizu H, Morosawa S, Hirano M, Hao K, Tsuburaya R, Ito K, Takahashi J. Inhibitory Effect of Renal Denervation on Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs in vivo -Evidence for the Kidney-Brain-Heart Interactions-
  15. Ogata T, Ito K, Shindo T, Hatanaka K, Eguchi K, Kurosawa R, Kagaya Y, Shimokawa H. Low-intensity Pulsed Ultrasound Enhances Angiogenesis and Ameliorates Contractile Cardiac Function in Pressure-Overloaded Hearts in Mice
  16. Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Sunamura S, Otsuki T, Numano K, Yaoita N, Tatebe S, Aoki T, Sugimura K. Selenoprotein P Promotes Vascular Smooth Muscle Cell Proliferation and Pulmonary Hypertension -A Possible Novel Therapeutic Target-
  17. Komatsu M, Takahashi J, Nakano M, Kondo M, Tsuburaya R, Hao K, Nishimiya K, Nihei T, Matsumoto Y, Ito K, Fukuda K, Shimokawa H. Usefulness of Dual Induction Tests for Coronary Artery Spasm and Lethal Ventricular Arrhythmias in Patients Surviving Out-of-Hospital Cardiac Arrest
  18. Nogi M, Satoh K, Kudo S, Omura J, Kikuchi N, Satoh T, Sunamura S, Kurosawa R, Ohtsuki T, Numano K, Suzuki K, Shimokawa H. Protective Roles of Small GTP-binding Protein GDP Dissociation Stimulator Against Angiotensin II-induced Thoracic Aortic Aneurysm Formation and Rupture in Mice -a Possible Novel Therapeutic Target- (Travel Award受賞)
  19. Kurosawa R, Satoh K, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Numano K, Suzuki K, Mohammad Abdul Hai Siddique, Elias-Al-Mamun M, Shimokawa H. Celastramycin Inhibits Pulmonary Arterial Smooth Muscle Cell Proliferation and Ameliorates Hypoxia-induced Pulmonary Hypertension in Mice (Travel Award受賞)
  20. Sunamura S, Satoh K, Suzuki K, Kudo S, Ikeda S, Kikuchi N, Omura J, Satoh T, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H. Crucial Role of ROCK1 to Maintain Contractile Cardiac Function in Response to Chronic Pressure-Overload in Mice
  21. Fukasawa K, Fukuda K, Nakano M, Hasebe Y, Kimura Y, Chiba T, Miki K, Shimokawa H. Impact of Sinus Rhythm Maintenance on Exercise Tolerance After Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
  22. Kasahara S, Sakata Y, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Sato M, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H. Comparable Prognostic Impacts of B-type Natriuretic Peptide Levels bBetween Heart Failure With Reduced and Preserved Ejection Fraction -a Report From the CHART-2 Study-
  23. Mohammad Abdul Hai Siddique, Satoh K, Kurosawa R, Elias-Al-Mamun M, Kikuchi N, Omura J, Satoh T, Nogi M, Sunamura S, Shimokawa H. Identification of Emetine as a Novel Therapeutic Agent for Pulmonary Hypertension in Rats -High-throughput Screening of 5,562 Compounds- (Travel Award受賞)
  24. Takeuchi M, Matsumoto Y, Kawamoto S, Kumagai K, Amamizu H, Ohyama K, Uzuka H, Nishimiya K, Kohzuki M, Saiki Y, Shimokawa H. Importance of Preoperative Pulmonary Rehabilitation in Patients With Thoracic Aortic Diseases
2016年11月6日〜9日, 12th International Symposium on Mechanisms of Vasodilatation (Rochester, MN, USA)

    <Invited lecture>

  1. * Shimokawa H. Diverse roles of NO and EDH in cardiovascular homeostasis.
  2. <Posters>

  3. Godo S, Saito H, Tanaka S, Ito A, Ikumi Y, Shimokawa H. Importance of the physiological balance between endothelium-derived nitric oxide and endothelium-dependent hyperpolarization in microcirculatory homeostasis in mice. J Vasc Res. 53 (Suppl 1):12,2016.
  4. Tanaka S, Sato S, Ikumi Y, Ito A, Saito H, Godo S, Shimokawa H. Roles of endothelium-dependent hyperpolarization in pulmonary microcirculation in mice. J Vasc Res. 53 (Suppl 1):17,2016.
2016年10月27日〜10月29日, 7th Scientific Meeting of the Asian Society of Vascular Biology (Hualien, Taiwan)

    <Plenary lecture>

  1. *Shimokawa H. Recent progress in vascular biology on pulmonary hypertension.
2016年9月17〜9月20日, The 20th Annual Scientific Meeting of the Heart Failure Society of America (Orlando, FL, USA)

    <Joint Session with ESC-HFA and JHFS: Guideline Session: A Global View>

  1. *Shimokawa H. Japanese Guideline Perspective.
  2. <Poster presentations>

  3. Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H. Differences in clinical characteristics and prognosis between heart failure with preserved ejection fraction and that with reduced ejection fraction -Insights from the CHART-2 Study- J Card Fail. 2016;22:S64.
  4. Tadaki S, Sakata Y, Miura Y, Fukumoto Y, Yano M, Kadokami T, Yasuda S, Daida H, Shimokawa H. Factors influencing daily exercise in patients with chronic heart failure A report from the multicenter prospective cohort study in Japan- J Card Fail. 2016;22:S76.
2016年8月27〜8月31日, ESC Congress 2016(Roma, Italy)

    <Acute myocardial infarction with no obstructive coronary atherosclerosis>

  1. *Shimokawa H, New insight in the pathogenesis.
  2. <Young Investigators Awards Session Coronary Pathophysiology and Microcirculation>

  3. Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Morosawa S, Hirano M, Watabe H, Funaki Y, Takahashi J, Ito K, Shimokawa H Evidence for involvement of inflammatory changes of perivascular adipose tissue in the pathogenesis of DES-induced hyperconstricting responses in pigs in vivo - impact of 18F-FDG PET imaging.
  4. <Poster session 1: Heart failure LV dysfunction>

  5. Tatebe S, Sugimura K, Aoki T, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Satoh K, Shimokawa H, Importance of acute hemodynamic effects of inhaled nitric oxide in optimization of heart failure treatment in patients with pulmonary hypertension owing to left heart disease.
  6. <Poster session 2: Heart failure / LV dysfunction>

  7. Hao K, Takahashi J, Sakata Y, Miyata S, Miura M, Shimokawa H, Prognostic impact of residual coronary stenosis in patients with ischemic heart failure after percutaneous coronary intervention - a report from the CHART-2 study.
  8. <Biological insights in myocardial remodelling>

  9. Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Miyata S, Shimokawa H, Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice.
  10. <Physiology of stenting from bench to bedside>

  11. Uzuka H, Matsumoto Y, Ohyama K, Nishimiya K, Amamizu H, Morosawa S, Hirano M, Hao K, Tsuburaya R, Ito K, Takahashi J, Funaki Y, Watabe H, Shimokawa H, Renal denervation suppresses coronary hyperconstricting responses after DES implantation in pigs in vivo - evidence for the kidney-brain-heart interactions.
  12. <Poster session 7: Heart failure / Left ventricular dysfunction>

  13. Kasahara S, Sakata Y, Miura M, Tadaki S, Tsuji K, Yamauchi T, Abe R, Oikawa T, Takahashi J, Miyata S, Shimokawa H, Prognostic risk stratification with plasma B-type natriuretic peptide levels in patients with chronic heart failure - a report from the CHART-2 Study.
  14. <Poster session 7: Angiogenesis and endothelial function>

  15. Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Kagaya Y, Eguchi K, Hanawa K, Aizawa K, Shiroto T, Miyata S, Kanai H, Shimokawa H, Pivotal roles of mechanotransduction via b1-integrin and caveolin-1 for angiogenic effects of low-intensity pulsed ultrasound.
2016年5月20日〜22日, The 9th International Conference on Biology, Chemistry and Therapeutic Applications of Nitric Oxide/ The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan (Sendai, Japan)

<President’s Lecture>

  1. *Shimokawa H. Diverse functions of endothelial NO synthases system: NO and EDH.
  2. <Symposium 7: NO and pulmonary circulation>

  3. Sugimura K, Tatebe S, Aoki T, Yamamoto S, Yaoita N, Satoh H, kozu K, Satoh K, Shimokawa H. Importance of acute hemodynamic effects of inhaled nitric oxide in optimization of heart failure treatment in patients with pulmonary hypertension due to left heart disease.
  4. <Symposium 8: NO and metabolic disorders>

  5. Tsutsui M, Tanada-Kina M, Sakanashi M, Otsuji Y, Shimokawa H, Arasaki A. Pathogenetic role of the exogenous NO production system in metabolic syndrome.
  6. <YIA>(最優秀賞受賞)

  7. Godo S, Saito H, Tanaka S, Ito A, Ikumi Y, Shimokawa H. Physiological balance between nitric oxide and endothelium-dependent hyperpolarization play important roles in microvascular homeostasis in mice.
  8. <Oral presentations>

  9. Satake Y, Satoh K, Kaiho Y, Tsutsui M, Arai Y, Shimokawa H. Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice.
  10. Ogoshi T, Kido T, Tsutsui M, Yamada S, Wang KY, Toyohira Y, Izumi H, Shimokawa H, Yanagihara N, Yatera K, Mukae H. Role of myelocytic nitric oxide synthases in hypoxic pulmonary hypertension in mice.
  11. <Poster presentations>

  12. Yada T, Shimokawa H, Tachibana H, Ogasawara Y. Crucial role of endogenous H2O2 as an endothelium-derived hyperpolarizing factor during reactive hyperemia in canine coronary microcirculation in vivo -An infrared fluorescence microscope study.
  13. Tanaka S, Saito S, Ikumi Y, Ito A, Saito H, Godo S, Shimokawa H. Roles of endothelium-dependent hyperpolarization in pulmonary microcirculation in mice.
  14. Tsutsui M, Uchida T, Furuno Y, Tanimoto A, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y. Combined treatment with irbesartan and amlodipine potently prevents acute myocardial infarction in subtotally nephrectomized triple nitric oxide synthases-deficient mice.
  15. Tsutsui M, Uchida T, Furuno Y, Tanimoto A, Ohya Y, Yanagihara N, Shimokawa H, Tamura M, Otsuji Y. Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.
  16. Tsutsui M, Kina-Tanada M, Sakanashi M, Ishida M, Ohya Y, Shimokawa H, Arasaki A. Long-term dietary nitrite and nitrate deficiency causes metabolic syndrome in mice.
  17. Tsutsui M, Kubota H, Noguchi K, Shimokawa H, Ohya Y, Kinohana M. Complete disruption of all nitric oxide synthases markedly reduces cerebral infarct size after middle cerebral artery occlusion in mice.
  18. Ogoshi T, Kido T, Tsutsui M, Kawanami Y, Toyohira Y, Shimokawa H, Yanagihara N, Yatera K, Mukae H. The role of nitric oxide in tracheobronchial ciliary motility.
2016年5月5日〜7日, AHA 2016 ATVB/PVD Council Scientific Sessions (Nashville, USA)
  1. Kikuchi N, Satoh K, Omura J, Otsuki T, Numano K, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H. Selenoprotein P promotes vascular smooth muscle proliferation and pulmonary hypertension -A possible novel therapeutic target- (Travel Award受賞)
2016年4月15日〜16日, The 8th Asian Pacific Congress of Heart Failure (Gyengju, Korea)
  1. Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Yamauchi T, Onose T, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H. Evidence for a distinct entity of heart failure with preserved ejection frcation -A report from the CHART-2 Study- (会長賞受賞)
  2. Kasahara S, Sakata Y, Miura M, Tadaki S, Onose T, Tsuji K, Yamauti T, Abe R, Oikawa T, Takahashi J, Miyata S, Shimokawa H. Plasma B-type natriuretic peptide levels predict long-term prognosis of patients with chronic herat failure -A report from the CHART-2 Study-
2016年2月18日, Milan Cardiology (Milano, Italy)

<Session: Assessing the patient with chest pain and normal coronary angiogram>

  1. *Shimokawa H. Provocative spasm testing.

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2015年 (*招待講演)
2015年11月8〜11日, American Heart Association (AHA) Scientific Sessions (Orlando, USA)

<e-Abstract session>

  1. Nishimiya K,Matsumoto Y, Takahashi J , Uzuka H , Wang H , Hao K, Tsuburaya R, Amamizu H, Kaz, Ohyama K, Komatsu M ,Odaka Y, Ito K, Shimokawa H. Enhanced adventitial vasa vasorum formation in patients with vasospastic angina -An optical frequency domain imaging study-
  2. Tadaki S, Sakata Y, Miyata S, Asakura M, Shimada K ,Yamamoto T, Kadokami T, Yasuda S, Miura T, Ando S, Yano M, Kitakaze M, Daida H, Shimokawa H. Prognostic impacts of metabolic syndrome in patients with chronic heart failure -A multicenter prospective cohort study-
  3. Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Otsuki T , NumanoK, Kozu K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H. Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-(Travel Award受賞)
  4. <Poster presentations>

  5. Tsuburaya R, Takahashi J, Nakamura A, Nozaki E, Sugi M, Yamamoto Y, Hiramoto T, Horiguchi S, Inoue K, Goto T, Kato A, Shinozaki T, Shimokawa H. Beneficial effects of long-acting nifedipine on coronary vasomotion abnormalities after drug-eluting stent implantation -The NOVEL Study-
  6. Aoki T, Sugimura K, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Shimokawa H. Effects of PTPA on respiratory functions in patients with CTEPH.
  7. Hao K, Takahashi J, Ito K, Yuanji Cui, Miyata S, Nishimiya K, Tsuburaya R, Matsumoto Y, Sakata Y, Yasuda S, Shimokawa H. Clinical characteristics of patients with acute myocardial infarction who did not receive primary percutaneous coronary intervention in Japan -Report from the Miyagi-AMI Registry Study-
  8. Miura M, Sakata Y, Miyata S, Tadaki S, Ushigome R, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Takahashi J, Shimokawa H. Impacts of supplemental use of angiotensin receptor blocker olmesartan in hypertensive patients with heart failure with preserved ejection fraction -Subgroup analysis of the SUPPORT Trial-
  9. Nishimiya K, Matsumoto Y, Uzuka H, Ohyama K, Hirano M, Shindo T, Tsuburaya R, Takahashi J, Ito K, Shimokawa H. Beneficial effects of novel bioresorbable polymer coating on enhanced coronary vasoconstricting responses after drug-eluting stent implantation in pigs in vivo.(Travel Award受賞)
  10. Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Shimokawa H. Thrombin-activated fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension.
  11. Saito H, Sato S, Ikumi Y, Tanaka S, Godo S, Shimokawa H. Important roles of endothelial caveolin-1/eNOS complex in maintaining microvascular homeostasis through endothelium-dependent hyperpolarization mediated mechanism.(Travel Award受賞)
  12. Shindo T, Ito K, Ogata T, Hatanaka K , Kurosawa R, Kagaya Y, Eguchi K, Hanawa K, Aizawa K, Shiroto T, Miyata S, Hasegawa H, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates left ventricular dysfunction in a mouse model of acute myocardial infarction - Potential involvement of mechanotransduction - (Travel Award受賞)
  13. Suzuki K, Satoh K, Sunamura S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Kudo S, Ikeda S, Otuki T, Shimokawa H. Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. (Travel Award受賞)
  14. Segawa M, Fukuda K, Nakano M, Kondo M, Hirano M, Shimokawa H. Time-course and influencing factors of ventricular tachy-arrhythmias after initiation of steroid therapy in patients with cardiac sarcoidosis.
  15. Segawa M, Fukuda K, Nakano M, Kondo M, Hirano M, Shimokawa H. Significance of improvement of advanced heart block in response to corticosteroid therapy in patients with cardiac sarcoidosis.
  16. Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H. Endothelial AMPK exerts protective effects against hypoxia-induced pulmonary hypertension in mice in vivo.
  17. Satoh T, Satoh K, Yaoita N, Kikuchi K, Omura J, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Shimokawa H. Crucial role of thrombin activatable fibrinolysis inhibitor in the pathogenesis of chronic thromboembolic pulmonary hypertension.
  18. Tsuji K, Sakata Y, Miura M, Tadaki S, Ushigome R, Yamauchi T, Sato K, Onose T, Abe R, Nochioka K, Takahashi J, Miyata S, Shimokawa H. Sex differences in clinical characteristics, management and prognosis in patients with heart failure with preserved ejection fraction: Insights from the CHART-2 Study.
  19. Cui Y, Hao K, Takahashi J, Miyata S, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H. Temporal trends in incidence and mortality of acute myocardial infarction for 30 years in Japan -A report from the Miyagi AMI Registry Study-
  20. Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Hao K, Tsuburaya R, Takahashi J, Ito K, Shimokawa H. Increased coronary perivascular adipose tissue volume on cardiac computed tomography in patients with vasospastic angina -Possible correlation with adventitial vasa vasorum formation- (Travel Award受賞)
  21. Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Hirano M, Takahashi J, Ito K, Shimokawa H. Involvement of enhanced inflammatory changes in the perivascular adipose tissue in the pathogenesis of coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo.
  22. Sunamura S, Satoh S, Suzuki K, Kudo S, Ikeda S, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Numano K, Shimizu T, Shimokawa H. ROCK1 plays a crucial role to maintain cardiac function in response to chronic pressure-overload in mice.
  23. Kozu K, Satoh K, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Otsuki T, Sato H, Miyata S, Shimokawa H. Plasma cyclophilin A as a useful biomarker for evaluation of the effects of percutaneous transluminal pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension.
  24. Numano K, Satoh K, Otsuki T, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Kozu K, Sato H, Miyata S, Shimokawa H. Plasma levels of cyclophilin A correlate with circulating inflammatory cytokines/chemokines in patients with pulmonary hypertension.
  25. Wang H, Matsumoto Y, Nishimiya K, Takahashi J , Uzuka H, Hao K, Tsuburaya R, Amamizu H, Ohyama K, Komatsu M, Odaka Y, Ito K, Shimokawa H. Association of enhanced adventitial vasa vasorum formation with atherosclerotic changes in the human coronary arteries adjacent to myocardial bridging -An optical frequency domain imaging study-
2015年10月16日〜17日, The 59th Annual Scientific Meeting of the Korean Society of Cardiology (Goyang)

<Joint Symposium with JCS: Signaling under HF, ischemia and cell senescence>

  1. *Shimokawa H. Translational research on Rho-kinase in cardiovascular medicine.
  2. <Joint Symposium with AHA: Global perspectives of heart failure>

  3. *Shimokawa H. Heart failure as a general pandemic in Asia.
2015年9月25日〜27日, The 10th World Congress for Microcirculation, The 40th Japanese Society for Microcirculation (Kyoto)

<Special Lecture 1>

  1. *Shimokawa H. Diverse roles of endothelial NO synthases system: NO and EDH.
  2. <Special Lecture 2>

  3. *Shimokawa H. Importance of coronary microvascular dysfunction.
  4. <Symposium 9: The role of EDRF (NO and EDHF), H2S and CO in microcirculation>

  5. Godo S, Saito H, Tanaka S, Ito A, Ikumi Y, Shimokawa H. Mechanisms for enhanced endothelium-derived hyperpolarizing factor-mediated responses.
  6. Tsutsui M, Shimokawa H, Yanagihara N, Otsuji Y. Significance of nitric oxide synthase in the cardiovascular system: Lessons from triple nitric oxide synthases null mice.
  7. <Satellie Symposium 2: A key cardiovascular signaling molecule in cardiovascular disease>

  8. Tsutsui M, Shimokawa H, Yanagihara N, Otsuji Y. Role of the endogeneous and exogeneous NO production systems in the pathogenesis of cardiovascular and metabolid diseases.
  9. <Poster>

  10. Yada T, Shimokawa H, Goto M, Ogasawara Y, Kajiya F. H2O2-induced coronary collateral arterioles compensataes NO-mediated small arteriolar endothelial dysfunction during coronary occlusion in diabetic dogs in vivo.
2015年9月14日〜17日, Endothelium-dependent Hyperpolarizations in Health and Disease (Nyborg, Denmark)

<2nd Tudor Griffith Lecture>

  1. *Shimokawa H. Endothelium-dependent hyperpolarizations in health and disease -Crucial roles of endothelim-derived reactive oxygen species in endothelium-dependent hyperpolarization. Acta Physiol. 215 (Suppl. 703):16,2015.
  2. <Regular presentation>

  3. Godo S, Saito H, Tanaka S, Ito A, Ikumi Y, Shimokawa H. Excessive endothelium-derived nitric oxide impairs cardiovascular homeostasis by suppressing endothelium-dependent hyperpolarization-mediated relaxation in mice. Acta Physiol. 215 (Suppl. 703):8,2015.
  4. Saito H, Sato S, Ikumi Y, Tanaka S, Godo S, Shimokawa H. Important roles of endothelial caveolin-1/eNOS complex in maintaining microvascular homeostasis through EDH-mediated mechanism. Acta Physiol. 215 (Suppl. 703):15,2015.
2015年9月2日〜3日, 2015 COVADIS (Coronary Artery Vasomotor Disorders Summit) Meeting (London, UK)
  1. *Shimokawa H. Coronary microvascular dysfunction registry: overview and demonstration of the CMD registry.
2015年8月29日〜9月2日, ESC Congress 2015 (London, UK)

<JCS-ESC Joint Symposium: Coronary Spasm Revisited>

  1. *Shimokawa H. Role of coronary spasm in ischemic heart disease: Japanese perspectives.
  2. <Basic and Translation Science Hot Line>

  3. Kikuchi N, Satoh K, Omura J, Satoh T, Kurosawa R, Nogi M, Tetebe S, Aoki T, Sugimura K, Shimokawa H. Selenoprotein P promotes vascular smooth muscle cell proliferation and pulmonary hypertension -A possible novel therapeutic target-
  4. <Best posters>

  5. Suzuki H, Satoh K, Tatebe S, Matsumoto M, Kondo M, Nakano M, Fukuda K, Hiraoka K, Tashiro M, Shimokawa H. Cardiac pacemaker stimulates the brain as well as the heart in humans -A PET functional study-
  6. Tsuburaya R, Takahashi J, Nozaki E, Sugi M, Hiramoto T, Horiguchi S, Inoue K, Goto T, Kato A, Shimokawa H. Impact of long-acting nifedipine on coronary vascular function after drug-eluting stent implantation -The NOVEL study-
  7. <Posters>

  8. Ohyama K, Matsumoto Y, Uzuka H, Nishimiya K, Hirano M, Kumagai M, Takahashi J, Ito K, Shimokawa H. Enhanced inflammatory changes in the perivascular adipose tissue and coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo.
  9. Odaka Y, Takahashi J, Tsuburaya R, Nishimiya K, Hao K, Matsumoto Y, Hirowatari Y, Shimokawa H. Plasma levels of serotonin as a novel biomarker for coronary microvascular dysfunction in patients with vasospastic angina.
  10. Sugimura K, Aoki T, Miura M, Yaoita N, Satoh H, Satoh K, Shimokawa H. Novel strategy for catheter interventional treatment of chronic thromboembolic pulmonary hypertension guided by optical coherence tomography imaging.
  11. Ushigome R, Sakata Y, Miyata S, Miura M, Tadaki S, Sato K, Yamauchi T, Onose T, Tsuji K, Shimokawa H. Recent trends in the prevalence, management and clinical outcomes of patients with symptomatic chronic heart failure in Japan -A report from the CHART studies-
  12. Yamauchi T, Sakata Y, Miyata S, Miura M, Tadaki S, Ushigome R, Sato K, Onose H, Tsuji K, Shimokawa H. Prognostic impacts of new onset atrial fibrillation in patients with chronic heart failure: an interim analysis of the CHART-2 study.
2015年8月28日, Invited Lecture at St. George’s University of London (London, UK)
  1. *Shimokawa H. The importance of coronary vasomotion abnormalities -From bench to bedside-
2015年5月23日〜26日, Heart Failure 2015(Seville, Spain)
  1. *Shimokawa H. Current status and future perspective of management of heart failure in Japan.
2015年5月14日〜16日, EuroPRevent2015(Lisboa, Portugal)

<Poster SessionUCardiac Rehabilitation>

  1. Takeuchi M, Matsumoto Y, Kawamoto S, Kumagai K, Takahashi J, Ito K, Sakata Y, Kohzuki M, Saiki Y, Shimokawa H. Safety and efficacy of pulmonary rehabilitation prior to surgery in patients with thoracic aortic disease -Importance of pre-operative respiratory tract clearance exercise-
2015年5月7日〜9日, Scientific Session, ATVB/PVD Council(San Francisco, USA)

<Plenary lecture>

  1. *Shimokawa H. Translational research on Rho-kinase in cardiovascular medicine.
  2. <Poster presentations>

  3. Otsuki T, Satoh K, Kikuchi N, Omura J, Kudo S, Sugimura K, Aoki T, Tatebe S, Shimokawa H. Plasma levels of cyclophilin A correlate with circulating inflammatory cytokines in patients with pulmonary hypertension.
  4. Satoh K, Sugimura K, Aoki T, Tatebe S, Shimizu T, Ikeda S, Yaoita N, Kudo S, Suzuki K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Sunamura S, Otsuki T, Shimokawa H. Plasma cyclophilin A as a useful biomarker for effective percutaneous transluminal pulmonary angioplasty in chronic thromboembolic pulmonary hypertension.
  5. Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Shimokawa H. SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis -Novel mechanism of the pleiotropic effects of statins-

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2014年 (*招待講演)
2014年11月15〜19日, American Heart Association (AHA) Scientific Sessions (Chicago, USA)

<Cardiovascular Seminar>

  1. *Shimokawa H. Importance of coronary artery spasm in cardiovascular medicine.
  2. <Clinical Science: Special Report>

  3. Sakata Y, Nochioka K, Miura M, Takada T, Tadaki S, Miyata S, Shiba N, Shimokawa H. Impact of additive use of olmesartan in patients with chronic heart failure: The Supplemental Benefit of Angiotensin Receptor Blocker in Hypertensive Patients with Stable Heart Failure Using Olmesartan (SUPPORT) Trial.
  4. <Oral presentations>

  5. Shindo T, Ito K, Hanawa K, Aizawa K, Shiroto T, Ogata T, Nishimiya K, Hasebe Y, Tsuburaya R, Miyata S, Hasegawa H, Yasuda S, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia -Potential involvement of mechanotransduction. (ATVB, Travel Award受賞)
  6. <Poster presentations>

  7. Sato K, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Ushigome R, Yamauchi T, Onose T, Tsuji K, Abe R, Shimokawa H. Emerging prognostic factors in patients with aortic stenosis -A report from the CHART-2 Study-
  8. Hao K, Takahashi J, Aoki T, Miyata S, Nihei T, Nishimiya S, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H. Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake Disaster.
  9. Satake H, Fukuda K, Sakata Y, Nakano M, Kondo M, Hasebe Y, Segawa M, Shimokawa H. Accumulation of risk factors increases the risk of fatal arrhythmic events in patients with ischemic heart disease or those with dilated cardiomyopathy -A Report from the CHART-2 Study-
  10. Suzuki K, Satoh K, Ikeda S, Kadomatsu K, Shimokawa H. Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice.
  11. Tatebe S, Sugimura K, Nochioka K, Aoki T, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H. Importance of acute hemodynamic effects of inhaled nitric oxide in optimization of heart failure treatment in patients with pulmonary hypertension due to left heart disease.
  12. Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Ushigome R, Yamauchi T, Sato T, Onose T, Abe R, Takahashi J, Shimokawa H. Sex differences in clinical characteristics and outcomes of patients with heart failure with preserved ejection fraction -A report from the CHART-2 Study.
  13. Kudo S, Satoh K, Tanaka S, Minami T, Kikuchi N, Omura J, Suzuki K, Ikeda S, Shimokawa H. Crucial role of SmgGDS in the inhibitory effects of statins on cardiac hypertrophy and fibrosis in mice.
  14. Tatebe S, Sugimura K, Nochioka K, Miura M, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H. Percutaneous transluminal balloon angioplasty ameliorates metabolic and renal dysfunctions associated with hemodynamic improvement in patients with chronic thromboembolic pulmonary hypertension.
  15. Godo S, Saito H, Sawada A, Sato S, Tanaka S, Shimokawa H. Physiological balance between nitric oxide and endothelium-derived hyperpolarizing factor plays a crucial role in cardiovascular homeostasis. (ATVB, Travel Award受賞)
  16. Uzuka H, Matsumoto Y, Nishimiya K, Hirano M, Ogata T, Shindo T, Hanawa K, Hasebe Y, Hao K, Tsuburaya R, Ito K, Takahashi J, Shimokawa H. Involvement of adventitial vasa vasorum and sympathetic nerves in coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo. (ATVB, Travel Award受賞)
  17. Nihei T, Takahashi J, Tsuburaya R, Hao K, Odaka Y, Nishimiya K, Matsumoto Y, Ito K, Shimokawa H. Prognostic impact of Rho-kinase activity in circulating leukocytes of patients with vasospastic angina.
  18. Tsutsui M, Kubota H, Noguchi K, Matsuzaki T, Hattori F, Sakanashi M, Kina-Tanada M, Uchida T, Nakasone J, Shimokawa H, Ohya Y, Sugahara K, Kakinohana M. Complete disruption of all nitric oxide synthase genes markedly reduces cerebralInfarct size after middle cerebral artery occlusion in mice.
  19. Miura M, Sugimura K, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Yaoita N, Sato H, Satoh K, Shimokawa H. Percutaneous transluminal pulmonary angioplasty improves hemodynamics and right ventricular function in patients with chronic thromboembolic pulmonary hypertension -One year follow-up study.
  20. Satoh K, Suzuki K, Omura J, Kikuchi N, Miyata S, Minami T, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miura M, Yamamoto S, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Nakamura K, Ito H, Kadomatsu K, Shimokawa H. Cyclophilin a and basigin promotes pulmonary hypertension by inducing inflammation and vascular smooth muscle cell proliferation.
  21. Suzuki H, Satoh K, Tatebe S, Matsumoto Y, Kondo M, Nakano M, Fukuda K, Watanuki S, Hiraoka K, Tashiro M, Shimokawa H. Evidence for activation of cerebral autonomic center in response to cardiac electrical stimulation in humans -A new finding of cardio-cerebral connection.
  22. Nishimiya K, Matsumoto Y, Takahashi J, Kato T, Oyama K, Uzuka H, Odaka Y, Nihei T, Hao K, Tsuburaya R, Ito K, Shimokawa H. Enhanced adventitial vasa vasorum formation in patients with vasospastic angina -Assessment with optical frequency domain imaging- (ATVB, Travel Award受賞)
2014年11月14日, Invited lecture at the University of Chicago (Chicago, USA)
  1. *Shimokawa H. Recent Progress in Medical Research on Rho-activated kinase.
2014年9月14〜17日, 18th Annual Scientific Assembly of Heart Failure Society of America (Las Vegas, USA)

<International Session>

  1. *Shimokawa H. Chronic Heart Failure Analysis and Registry in the Tohoku District of Japan --The CHART Studies-
  2. <Posters>

  3. Ushigome R, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Yanauchi T, Takahashi J, Shimokawa H. Recent trend in clinical characteristics, management and prognosis of patients with dilated cardiomyopathy in Japan --A report from the CHART Studies-
  4. Nochioka K, Sakata Y, Miyata S, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H. Prognsotic impact of statin use in patients with heart failure with preserved ejection frcation --A report from the CHART-2 Study-
2014年8月30〜9月3日, European Society Congress 2014 (Barcelona, Spain)

<William Harvey Lecture>

  1. *Shimokawa H. Importance of coronary vasomotion abnormalities --From bench to bedside-
  2. <Symposium: Treatment challenges in stable coronary artery disease>

  3. Shimokawa H. The patients with refractory angina --novel therapies-
  4. <Symposium: Non-invasive treatment approaches to stable angina in different clinical scenarios>

  5. Shimokawa H. Patients with refractory angina --novel therapies-
  6. <YIA session: Coronary pathophysiology and microcirculation>

  7. Nishimiya K, Matsumoto Y, Takahashi J, Kato T, Odaka Y, Nihei T, Hao K, Tsuburaya R, Ito K, Shimokawa H. Enhanced adventitial vasa vasorum formation in patients with vasospastic angina --Assessment with optical frequency domain imaging-
  8. <Oral presentations>

  9. Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Fukumoto Y, Kawashima R, Taki Y, Shimokawa H. Decreased cerebral blood flow and BDNF levels are associated with depression and memory impairment in patients with heart failure --Brain Assessment and Investigation in Heart Failure Trial (B-HeFT)-
  10. Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Ushigome R, Yamauchi T, Shimokawa H. Predictors for the transition to de novo heart failure in sytage B asymptomatic patients --A report from the CHART-2 Study-
  11. Nihei T, Takahashi J, Tsuburaya R, Hao K, Odaka Y, Nishimiya K, Matsumoto Y, Ito K, Shimokawa H. Prognostic impact of Rho-kinase activity in circulating leukocytes of patients with vasospastic angina.
  12. <Poster presentations>

  13. Nishimura K, Takegami M, Miyamoto Y, Shimokawa H, Nakamura M, Takeishi Y, Hirata K, Shishido T, Yasuda S, Naitou H. Association of seismic intensity after the Great East Japan Earthquake and sudden out-of-hospital cardiac arrest.
  14. Hao K, Takahashi J, Aoki T, Miyata S, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H. Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan earthquake Disaster.
  15. Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki R, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H. Comparison of the prognostic impact of diabetes mellitus between ischemic and non-ishemic heart failure --A report from the CHART-2 Study-
  16. Uzuka H, Matsumoto Y, Nishimiya K, Shindo T, Hanawa K, Hasebe Y, Tsuburaya R, Takahashi J, Shimokawa H. Possible involvement of adventitial sympathetic nerve in the coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo.
  17. Tatebe S, Sugimura K, Nochioka K, Miura M, Yamamoto S, Satoh K, Shimokawa H. Percutaneous transluminal pulmonary angioplasty ameliorates metabolic and renal dysfunctions associated with hemodynamic improvement in patients with chronic thromboembolic pulmonary hypertension.
  18. Sugimura K, Nochioka K, Tatebe S, Yamamoto S, Miura M, Kato T, Satoh K, Shimokawa H. Usefulness of optical coherence tomography imaging in chronic thromboembolic pulmonary hypertension.
2014年8月22〜24日, Asian Society of Vascular Bilogy Meeting (Kuala Lumpur, Malaysia)

<Asian Lecture in Vascular Biology>

  1. *Shimokawa H. Light and dark of reactive oxygen species for vascular function.
2014年6月25〜28日, Computer-Assisted Radiology and Surgery (CARS) 2014 (Fukuoka, Japan)

<Keynote Lecture>

  1. *Shimokawa H. Extracorporeal cardiac shock wave therapy.
2014年5月4〜7日, 2014 World Congress of Cardiology (Melbourne, Australia)

<Symposium: Coronary vasospasm: what do we know and why is it important?>

  1. *Shimokawa H. Pathogenesis of vasospastic angina.
2014年5月1〜4日, Scientific Session 2014 of the Arteriosclerosis, Thrombosis and Vascular Biology Council (Tronto, Canada)
  1. Ikeda S, Satoh K, Kikuchi N, Miyata S, Suzuki K, Omura J, Shimizu T, Fukumoto Y, Sakata Y, Shimokawa H. Crucial role of Rho-kinase in pressure-overload-induced right ventricular hypertrophy and dysfunction in mice -A possible novel therapeutic target of right ventricular failure-
  2. Satoh K, Suzuki K, Omura J, Kikuchi N, Miyata S, Minami T, Sugimura K, Aoki T, Nochioka K, Tatebe T, Miura M, Yamamoto S, Shimizu T, Yaoita N, Fukumoto Y, Nakamura K, Ito H, Kadomatsu K, Shimokawa H. Basigin promotes vascular smooth muscle proliferation and pulmonary hypertension.
2014年3月29〜31日, Annual Scientific Meeting of the American Collge of Cardiology (Washington DC, USA)

<Symposium: The What, When, Why and How of Testing and Treating Coronary vasospasm Disorders?>

  1. *Shimokawa H. How should coronary spasm testing be performed?
2014年3月15〜18日, Orthopaedic Research Society(ORS) 2014 Annual Meeting (New Orleans, USA)
  1. Yahata K, Ozawa H, Kanno H, Yamaya S, Tateda S, Ito K, Shimokawa H, Itoi E. Low-energy extracorporeal shock wave therapy promotes VEGF expression in various neural cells and enhances neuroprotective effect after spinal cord injury.
  2. Tateda S, Ozawa H, Kanno H, Yamaya S, Yahata K, Ito K, Shimokawa H, Itoi E. Therapeutic Potential of Low-Energy Extracorporeal Shock Wave for Neuropathic Pain after Spinal Cord Injury.
2014年2月27〜3月1日, The 2nd International Conference on Heart & Brain (ICHB) (Paris, France)
  1. Suzuki H, Yasuharu Matsumoto, Hideki Ota, Koichiro Sugimura, Jun Takahashi, Kenta Ito, Katsutoshi Furukawa, Yoshihiro Fukumoto, Hiroyuki Arai, Shoki Takahashi, Yasuyuki Taki, Hiroaki Shimokawa. Decreased activity of the hippocampus is associated with depression in heart failure patients -Brain investigation in Heart Failure Trial (B-HeFT)-.
2014年2月13〜15日, Milan Cardiology (Milan, Italy)
  1. *Shimokawa H. Vasospastic angina: the Japanese registry.

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2013年 (*招待講演)
2013年11月16〜20日, American Heart Association (AHA) Scientific Sessions (Dallas, USA)

<Oral presentations>

  1. Nishimiya K, Matsumoto Y, Takahashi J, Shindo T, Hanawa K, Hasebe Y, Tsuburaya R, Shiroto T, Ito K, Ishibashi-Ueda H, Yasuda S, Shimokawa H. Important role of adventitial vasa vasorum in the pathogensis of coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo. (Travel Award受賞)
  2. Satoh K, Fukumoto Y, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miura M, Yamamoto S, Shimizu T, Yaoita N, Minami T, Miyata S, Suzuki K, Kikuchi N, Nakamura K, Ito H, Kadomatsu K, Shimokawa H. Basigin promotes inflammation and pulmonary hypertension through synergistic cooperation with extracellular Cyclophilin A.

<Poster presentations>

  1. Godo S, Saito H, Sawada A, Enkhjargal B, Shimokawa H. Importance of physiological balance between nitric oxide and endothelium-derived hyperpolarizing factor in cardiovascular homeostasis.
  2. Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, Tuburaya R, Hasegawa H, Yasuda S, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia.
  3. Hao K, Takahashi J, Miyata S, Sakata Y, Nihei T, Tsuburaya R, Shiroto T, Ito Y, Matusmoto Y, Ito K, Yasuda S, Shimokawa H. Characteristics of patients with acute myocardial infarction who did not receive primary percutaneous coronary intervention in Japan -A report from the Miyagi AMI Registry Study-
  4. Hasebe Y, Fukuda K, Kumagai K, Karibe A, Hiroyuki Satake, Shafee MA, Kondo M, Nakano M, Wakayama Y, Shimokawa H. Characteristics and long-term prognosis of patients with dilated cardiomyopathy and ventricular tachycardia due to Lamin A/C gene mutations.
  5. Ikeda S, Fukumoto Y, Shimizu T, Satoh K, Shimokawa H. Cardiac specific overexpression of dominant-negative Rho-kinase suppresses pressure overload-induced right ventricular failure in mice.
  6. Miura M, Sakata Y, Miyata S,Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H. Subclinical microalbuminuria is associated with poor prognosis in patients with chronic heart failure with preserved renal function -A Report from the CHART-2 Study-
  7. Nergui S, Fukumoto Y, Do.e Z, Md. Mamun EA, Shimokawa H. Molecular and cellular mechanisms of right ventricular remodeling in pulmonary hypertension.
  8. Nochioka K, Sakata Y, Miyata S, Takahashi J, Miura M, Takada T, Tadaki S, Ushigome R, Shimokawa H. Statin use is associated with reduced mortality in patients with heart failure with preserved ejection fraction -A report from the CHART-2 Study-
  9. Satake H, Fukuda K, Wakayama Y, Kondo M, Nakano M, Hasebe Y, Shafee MA, Shimokawa H. Severity of sleep-disordered breathing influences the prognosis of patients with chronic heart failure.
  10. Takahashi J, Sakata Y, Nochioka K, Miura M, Takada T, Miyata S, Shimokawa H. Prognostic impact of coronary revascularization therapy in patients with ischemic heart failure.
  11. Yaoita N, Fukumoto Y, Kawamura T, Horiuchi H, Shimokawa H, Resistance of thrombus to fibrinolysis in patients with chronic thromboembolic pulmonary hypertension -Possible involvement of thrombin-activated fibrinolysis inhibitor (TAFI)-
2013年11月16〜20日, AMIA 2013 Annual Symposium (Washington, DC, USA)
  1. Nakayama M, Shimokawa H. Usefulness of MFER for the diagnosis of vasospastic angina with coronary spasm provocation test during coronary angiography.
2013年11月14日, Invited Lecture at Mayo Clinic (Rochester)
  1. *Shimokawa H. Recent progress in coronary vasomotion research.
2013年10月4〜6日, MOVD 2013 (11th International Symposium on Mechanisms of Vasodilatation) (Zurich)
  1. Godo S, Saito H, Sawada A, Enkhjargal B, Shimokawa H. Importance of physiological balance between nitric oxide and EDHF in endothelium-dependent vasodilatation.
2013年9月14日, 2013 Annual Scientific Meeting of Heart Failure Society of America (HFSA) (Orlando, USA)

<HFSA-HFA of the ESC-JHFS Joint Session>

  1. *Shimokawa H. Increased occurrence of heart failure in the Great Japan Earthquake.
2013年9月8〜11日, The 13th International Conference on Endothelin (Tokyo, Japan)
  1. Satake H, Fukuda K, Nakano M, Wakayama Y, Kondo M, Hasebe Y, Shafee AM, Shimokawa H. Prognosis of sleep-disorder breathing for chronic heart failure and the effectiveness of nocturnal home oxygen therapy and continuous positive airway pressure.
  2. Yamamoto S, Matsumoto Y, Nochioka K, Miura M, Tatebe S, Sugimura K, Suzuki T, Fukumoto Y, Shimokawa H. Potential involvement of functional tricuspid regurgitation in the diagnostic error to assess pulmonary arterial pressure by Doppler echocardiography.
2013年9月4〜5日, Coronary Artery Vasospastic Disorder Summit (Amsterdam, Netherlands)
  1. *Shimokawa H. Pathophysiological mechanisms of coronary artery spasm.
  2. *Shimokawa H. Cardiac arrest and vasospstic angina.
  3. *Shimokawa H. How should coronary spasm testing be performed?
2013年8月31日〜9月4日,European Society of Cardiology 2013 (Amsterdam, Netherlands)

<YIA>

  1. Nishimiya K, Matsumoto Y, Takahashi J, Tsuburaya R, Shiroto T, Ito K, Ishibashi-Ueda H, Yasuda S, Shimokawa H. Impact of adventitial vasa vasorum in the pathogenesis of coronary vasomotor dysfunction after drug-eluting stent implantation in pigs in vivo.

<Best Poster Award>

  1. Nishimiya K, Matsumoto Y, Takahashi J, Hanawa K, Hasebe Y, Tsuburaya R, Shiroto T, Ito K, Shimokawa H. Essential role of polymer coating in the pathogenesis of coronary hyperconstricting responses after drug-eluting stent implantation in pigs in vivo.

<Oral presentation>

  1. Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Shimokawa H. Different impact of elevated heart rate on cardiovascular events between heart failure with reduced ejection fraction and preserved ejection fraction -A report from the CHART-2 Study-

<Poster presentations>

  1. Hao K, Takahashi J, Ito K, Miyata S, Sakata Y, Ito Y, Matsumoto Y, Nakayama M, Yasuda S, Shimokawa H. Improved emergency care of acute myocardial infarction after the Great East Japan Earthquake Disaster.
  2. Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H. Mortality risk stratification according to combined heart rate and systolic blood pressure in patients with chronic heart failure -A report from the CHART-2 Study-
  3. Miura M, Sakata Y, Miyata S, Nochioka K, Tatebe S, Tadaki S, Takahashi J, Shiba N, Shimokawa H. Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure.
  4. Nihei T, Takahashi J, Kikuchi Y, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama Y, Ito K, Shimokawa H. Circadian variation of Rho-kinase activity associated with enhanced coronary reactivity in patients with vasospastic angina.
  5. Suzuki H, Matsumoto Y, Ota H, Kotozaki Y, Takahashi J, Ito K, Fukumoto Y, Kawashima R, Taki Y, Shimokawa H. Interactions between the heart and the brain in heart failure patients assessed by magnetic resonance imaging -Interim results from Brain assessment and investigation in Heart Failure Trial (B-HeFT)-
  6. Suzuki H, Sumiyoshi A, Matsumoto Y, Yoshikawa T, Fukumoto Y, Yanai K, Taki Y, Kawashima R, Shimokawa H. Structural abnormality of the hippocampus and depressive symptoms in a rat model of heart failure.
  7. Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Shimokawa H. Factors influencing transition to symptomatic heart failure in Stage-B asymptomatic patients -A report from the CHART-2 Study-
  8. Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Miura M, Oikawa-Wakayama M, Kagaya Y, Shimokawa H. Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension.
  9. Yamamoto S, Matsumoto Y, Nochioka K, Miura M, Tatebe S, Sugimura K, Suzuki T, Fukumoto Y, Shimokawa H. Potential involvement of functional tricuspid regurgitation in the diagnosis error to assess pulmonary arterial pressure by doppler echocardiography.
2013年8月20日〜23日,MEDINFO2013 (Copenhagen, Denmark)
  1. Nakayama M, Shimokawa H. Evaluation of an Electrocardiogram on QR code. (Distinguished Poster Award 2013)
2013年7月14〜19日,The 29th International Symposium on Shock Waves (Madison, WI, USA)
  1. *Shimokawa H. Development of extracorporeal shock wave therapy for the treatment of ischemic heart disease.
  2. Yamamoto H, Hasebe Y, Kondo M, Fukuda K, Takayama K, Shimokawa H. Development of a novel shock wave catheter ablation system.
2013年6月30〜7月4日,International Society of Heart Research (ISHR) XXI World Congress (San Diego, USA)

<Symposium: Mechanisms of REDOX signaling>

  1. *Shimokawa H. Hydrogen peroxide as an EDHF.
2013年5月1〜3日,Scientific Session 2013 of the Arteriosclerosis, Thrombosis and Vascular Biology Council (Lake Buena Vista, FL, USA)

<Oral presentations>

  1. Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Shimokawa H. Crucial role of ROCK2 in vascular smooth muscle cells in hypoxia-induced pulmonary hypertension in mice.

<Poster presentations>

  1. Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Shimizu T, Takagi Y, Tsuburaya R, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H. Cyclophilin A is a novel biomarker for oxidative stress and atherosclerotic diseases.
2013年1月7日,Invited Lecture at the Robert-Bosch-Krankenhaus (Stuttgart, Germany)
  1. *Shimokawa H. The pathogenesis of coronary artery spasm.

研究業績一覧へ |このページのTOPへ

2012年 (*招待講演)
2012年11月3〜7日,American Heart Association (AHA) Scientific Sessions (Los Angeles, USA)

<Best of Other CV Meeting, International>

  1. *Shimokawa H. The Japanese Circulation Society.
  2. Doe Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto, AokiT, Nohicoka K, Satoh K, Suvd N, Kondo M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Kikuchi Y, Takahashi J, Shimokawa H. Rho kinase activity in circulating leukocytes as a novel bio marker of heart failure. (#12636)
  3. Ellawindy A, Satoh K, Tanaka S, Ikeda S, Shimizu T, Noda K, Fukumoto Y, Kobayashi K, Nakayama K, Shimokawa H. Spontaneous development of arrhythmogenic right ventricular cardiomyopathy in mice overexpressing dominant-negative Rho-kinase in vascular smooth muscle cells. (#10984)
  4. Enkhjargal B, Godo S, Sawada A, Noda K, Shimokawa H. Role of endothelial AMPK in endothelium-derived hyperpolarizing factor-mediatedrelaxations of resistance arteries in mice. (#10710)
  5. Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, GaoJY, Hasegawa H, Yasuda S, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine modelof chronic myocardial ischemia. (#12873)
  6. Hasebe Y, Fukuda K, Yamamoto H, Nishimiya K, Hanawa K, Kondo M, Nakano M, Wakayama Y, TakayamaK, Shimokawa H. Development of a novel shock wave catheter ablation system -a feasibility study in pigs in vivo.(#10897)

<International Forum: Japan>

  1. Ito Y, Takahashi J, Hao K, Takagi Y, Tsuburaya R, Shiroto T, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H. Factors influencing the higher in-hospital mortality of female patients with acute myocardial infarction.
  2. Ito Y, Takahashi J, Hao K, Takagi Y, Tsuburaya R, Shiroto T, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H. Factors influencing the higher in-hospital mortality of female patients with acute myocardial infarction. (#12895)
  3. Minami T, Tanaka S, Fukumoto Y, Miyoshi J, Takai Y, Williams K, Liao J, Shimokawa H. HMG-CoA reductase inhibitors exert the pleiotropic effects through SmgGDS up-regulation with a resultant Rac1 degradation and reduced oxidative stress in vitro and in vivo. (#12774)
  4. Miura M, Sakata Y, Nohicoka K, Takada T, Miyata S, Takahashi J, Shiba N, Shimokawa H. Risk stratification with control status of systolic blood pressure and heart rate in patients with chronic heart failure -an interim analysis of the CHART-2 study-. (#12475)
  5. Miura Y, Sugimura K, Fukumoto Y, Satoh K, Nohicoka K, Aoki T, TatebeS, Yamamoto S, Shimokawa H. Percutaneous transluminalpulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis of patients with distal-type chronic thromboembolic pulmonary hypertension. (#13752)
  6. Nihei T, Takahashi J, Kikuchi Y, Hao K, Takagi Y, Tsuburaya R, Shiroto T, ItoY, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H. Enhanced rho-kinase activity in circulating neutrophils of patients with vasospasticangina after the Great East Japan Earthquake. (#9574)
  7. Nishimiya K, Matsumoto Y, Takahashi J, Hasebe Y, Hanawa K, Tsuburaya R, Shiroto T, Ito K, Ishibashi-UedaH, Yasuda S, Shimokawa H. Beneficial effects of polymer-free biolimus-eluting stents on coronary vasomotion in pigs in vivo -possible involvement of rho-kinase inhitibiton-. (#12800)
  8. Noda K, Nakajima S, Fukumoto Y, Shimokawa H. Rho-kinase causes manifestations of metabolic syndrome thorough AMPK pathway inhibition in mice in vivo and in vitro. (#9740)
  9. Saito H, NakamuraA, Sato K, Satake H, Fukui S, Endo H, Takahashi T, Nozaki E, Tamaki K, Shimokawa H. Increased incidence of acute myocardial infarction after the Great East Japan Earthquake. (#12850)
  10. Satoh K, Fukumoto Y, Sugimura K, Miura M, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Ito H, Shimokawa H. Plasma cyclophilin A as a novel biomarker for pulmonary hypertension in humans. (#11189)
  11. Shafee MA, Fukuda K, Wakayama Y, Nakano M, Kondo M, Hasebe Y, Kawana A, Shimokawa H. Delayed Enhancment on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. (#12767)
  12. Shafee MA, Fukuda K, Wakayama Y, Nakano M, Kondo M, Hasebe Y, Kawana A, Shimokawa H. Positive cardiac positron emission tomography correlates with the appearance of advanced heart block in patients with cardiac sarcoidosis. (#12742)
  13. ShimizuT, Tanaka S, Satoh K, Fukumoto Y, Shimokawa H. ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice. (#12299)
  14. Shiroto T, Romero M, Sugiyama T, Sartoretto JL, Kalwa H, Yan Z, Shimokawa H, Michel T. Caveolin-1 is a critical determinant of vascular oxidative stress. (#13770)
  15. Takada T, Sakata Y, Miyata S, Takahashi J, Nohicoka K, Miura M, Shimokawa H. Increased heart rate as a significant prognostic factor in patients with heart failure with preserved ejection fraction -a report from the CHART-2 study. (#11724)
  16. Takada T, Sakata Y, Miyata S, Takahashi J, Nohicoka K, Miura M, Shimokawa H. Factors influencing the development of De novo heart failure in stage-b asymptomatic patients -a report from the CHART-2 study-. (#12749)
  17. Takagi Y, Takahashi J, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Prognostic impact of long-acting nitrate therapy in patients with vasospastic angina -areport from the Japanese Coronary Spasm Association-. (#12627)

<International Forum: Japan>

  1. Takahashi K, Matsumoto Y, Noda K, Do.e Z, Satoh K, Fukumoto Y, Shimokawa H. Combination therapy with amlodipine and atrovastatin prevents abdominal aortic aneurysm formation in apoE-deficient mice.
  2. Takahashi K, Matsumoto Y, Noda K, Do.eZ, Satoh K, Fukumoto Y, Shimokawa H. Combination therapy with amlodipine and atrovastatin prevents abdominal aortic aneurysm formation in apoE-deficient mice. (#11426)
  3. Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nohicoka K, Aoki T, Yamamoto S, Oikawa-WakayamaM, KagayaY, Shimokawa H. Prognostic significance of enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall in patients with pulmonary hypertension. (#10873)
  4. Tsuburaya R, Takahashi J, Takagi Y, Ito Y, Matsumoto Y, Ito K, Nakayama M, Shimokawa H. Beneficial effects of a single prophylactic hemodialysis on renal function worsening after percutaneous coronary intervention in patients with severe CKD. (#13968)
2012年10月14日,Neuroscience 2012 (Society for Neuroscience) (New Orleans, USA)
  1. Suzuki H, Sumiyoshi A, Taki Y, Matsumoto Y, Kawashima R, Shimokawa H. Voxel-based morphology in a rat model of cardiopulmonary resuscitation.
2012年8月30日,Invited lecture at the University of Leipzig (Leipzig, Germany)
  1. *Shimokawa H. The Great East Japan Earthquake Disaster and cardiovascular diseases.
  2. *Shimokawa H. The importance of what we cannot see.
2012年8月25日〜29日,European Society of Cardiology Congress 2012 (Munich, Germany)

<Hotline Session>

  1. *Shimokawa H. The Great East Japan Earthquake Disaster and cardiovascular diseases.

<Meet the Trialist>

  1. *Shimokawa H. The Great East Japan Earthquake Disaster and cardiovascular diseases.

<Mechanisms and Outcome of Vasospastic Angina>

  1. *Shimokawa H. Pathogenetic mechanisms of vasospastic angina.

<YIA>

  1. Nishimiya K, Matsumoto Y, Takahashi J, Tsuburaya R, Ito Y, Ito K, Ishibashi-U H, Yasuda S, Shimokawa H. New generation biolimus A9-eluting stent suppresses coronary hyperconstricting responses and inflammation through Rho-kinase pathway inhibition in pigs -Comparison with a Sirolimus-eluting stent-

<Oral presentations>

  1. Sugimura K, Fukumoto Y, Satoh K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimokawa H. Remarkable effectiveness of percutaneous transluminal pulmonary angioplasty for hemodynamics and long-term prognosis in patients with distal-type chronic thromboembolic pulmonary hypertension.
  2. Takagi Y, Takahashi J, Yasuda S, Ogata Y, Sumiyoshi T, Goto T, Tanabe Y, Sueda S, Ogawa H, Shimokawa H. Development of clinical risk score for predicting cardiac events in patients with vasospastic angina -A report from the multicenter registry study by the Japanese coronary spasm association-

<Poster presentations>

  1. Miura M, Shiba N, Takahashi J, Nochioka K, Takada T, Hiramoto T, Inoue K, Tamaki K, Shimokawa H. Prognostic impact of blood urea nitrogen increase during admission in patients with acute heart failure.
  2. Nakamura A, Saito H, Satake H, Sato K, Fukui S, Endo H, Takahashi T, Nozaki E, Tanaki K, Shimokawa H. Increased risk of myocardial infarction after the Great East Japan Earthquake.
  3. Nochioka K, Shiba N, Takahashi J, Miura M, Takada T, Shimokawa H. Nutritional status and prognsosis of stage-B patients.
  4. Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Takagi Y, Takahashi J, Shimokawa H. Plasma cyclophilin A level is a novel biomarker of coronary artery disease.
  5. Nihei T, Takahashi J, Kikuchi Y, Ito Y, Tsuburaya R, Takagi Y, Nakayama M, Ito K, Yasuda S, Shimokawa H. Increased Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake disaster.
  6. Miura M, Shiba N, Takahashi J, Nochioka K, Takada T, Shimokawa H. Heart rate control is important event in heart failure patients -An interim analysis of the CHART-2 Study-
2012年5月2日, Invited lecture at the Flinders Medical Center (Adelaide, Australia)
  1. *Shimokawa H. Present status & future perspectives of heart failure in Japan.
2012年5月1日, Invited lecture at the Cardiac Society of Australia & New Zealand Meeting (Adelaide, Australia)
  1. *Shimokawa H. Coronary spasm in 2012: Mechanisms and treatment.
2012年5月1日, Invited lecture at the Cardiology Academic Meeting of the Queen Elizabeth Hospital (Adelaide, Australia)
  1. *Shimokawa H. Recent progress in endothelial research.
2012年5月1日, Invited lecture at Medical Grand Round of the Queen Elizabeth Hospital (Adelaide, Australia)
  1. *Shimokawa H. Rho-kinase as an important CV therapeutic target.
2012年4月30日, Invited lecture at Royal Adelaide Hospital (Adelaide, Australia)
  1. *Shimokawa H. Recent progress in endothelial research.
2012年3月30日,Invited lecture at San Raffaele University (Milano, Italy)
  1. *Shimokawa H. Rho-kinase as an important new therapeutic target in cardiovascular medicine.
2012年3月30日,Rome Cardiology Forum 2012 (Rome, Italy)

<Symposium: Update on coronary vasomotion>

  1. *Shimokawa H. Update on coronary spasm.
2012年2月4日〜7日,Orthopaedic Research Society (ORS) 2012 Annual Meeting (San Francisco, USA)
  1. Yamaya S, Ozawa H, Kanno H, Sekiguchi A, Kishimoto K, Ito K, Shimokawa H, Itoi E. Effect of Low-Energy Extracorporeal Spinal Shock Wave Therapy on Spinal Cord Injury. (#2091)
2012年2月2日〜5日,The first Up Close and Personalized, International Congress on Personalized Medicine (Florence, Italy)
  1. Nakayama M, Shimokawa H. Importance of the Seattle Heart Failure Score-Guided Therapy in the Management of Heart Failure.

研究業績一覧へ |このページのTOPへ

2011年 (*招待講演)
2011年11月27日〜12月2日,The Radiological Society of North America The 97th Scientific Assembly and Annual Meeting (Chicago, USA)
  1. Ota H, Oikawa M, Takeda M, Yasuda S, Takahashi J, Ito Y, Fukumoto Y, Hihano S, Shimokawa H, Takahashi S. Carotid plaque vulnerability by 3.0T MR imaging is associated with the complexity of coronary artery disease in patients with angina.
2011年11月12日〜16日,American Heart Association (AHA) Scientific Sessions (Orlando, USA)
  1. Aizawa K, Yasuda S, Takahashi J, Kikuchi Y, Tsuburaya R, Ito Y, Takeda M, Takii T, Shimokawa H. Involvement of Rho-kinase activation in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in patients with coronary artery disease. (#8768)
  2. Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Nakayama M, Shimokawa H. Prognostic impact of myocardial fibrosis in patients with heart failure -Comparison between preserved and reduced ejection fraction heart failure- (#12377)
  3. Aoki T, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H. Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics in patients with distal-type chronic thromboembolic pulmonary hypertension. (#11867)
  4. Hanawa K, Yasuda S, Aizawa K, Gao JY, Tsuburaya R, Kikuchi Y, Hao K, Ito Y, Ito K, Hasegawa H, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. (#12327)
  5. Hao K, Yasuda S, Takii T, Ito Y, Kawana A, Takahashi J, Takeda M,Ito K, Shimokawa H, on behalf of the MIYAGI-AMI Study Investigators. Changes in prevalence and risk factors of acute myocardial infarction in the rural and urban district in Japan -Report from MIYAGI-AMI Registry Study- (#10522)
  6. Hasebe Y, Kondo M, Yamamoto H, Nakano M, Wakayama Y, Fukuda K, Takayama K, Shimokawa H. Development of a novel shock wave catheter ablation system to overcome the limitations of the present radiofrequency catheter ablation therapy. (#10168)
  7. Kawana A, Yasuda S, Takagi Y, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H, on behalf of the Japanese Coronary Spasm Association. Gender differences in clinical characteristics and risk factors of patients with vasospastic angina -A report from the nationwide multi-center registry by the Japanese Coronary Spasm Association- (#9477)
  8. Kikuchi Y, Aizawa K, Yasuda S, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H. Usefulness of Rho-kinase activity in circulating neutrophils for disease activity assessment of vasospastic angina. (#10222)
  9. Nochioka K, Shiba N, Miura M, Shimokawa H. Statin use, but not low density lipoprotein cholesterol levels, is associated with better survival in Japanese patients with ischemic heart failure -Interim Analysis of the CHART-2 Study- (#14231)
  10. Nakajima S, Ohashi J, Sawada A, Noda K, Shimokawa H. Evidence for the important role of the bone marrow in modulating microvascular endothelial responses and metabolic functions in mice. (#10236)
  11. Noda K, Hosoya M, Nakajima S, Ohashi J, Shimokawa H. Combination therapy with olmesartan and azelnidipine exerts anti-atherogenic effects in diabetic Apolipoprotein E-deficient mice. (#9659)
  12. Ohashi J, Sawada A, Takaki A, Noda K, Nakajima S, Shimokawa H. Multiple mechanisms are involved in enhanced endothelium-derived hyperpolarizing factor (EDHF)-mediated responses in microvessels in mice -A clue for novel strategy for vascular protection- (#11751)
  13. Satoh K, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Tatebe S, Yamamoto S, Shimizu T, Nakamura K, Shimokawa H. Cyclophilin A plays an important role in the pathogenesis of pulmonary arterial hypertension in humans -Involvement of Rho-kinase Pathway- (#10569)
  14. Schroder K, Benkhoff SB, Shimokawa H, Grisk O, Brandes RP. Leptin improves vascular function by inducing vascular expression of neuronal nitric oxide synthase (nNOS). (#12347)
  15. Serizawa F, Ito K, Sato A, Shimokawa H. Non-invasive extracorporeal shock wave therapy ameliorates walking ability of patients with peripheral artery disease and intermittent claudication. (#11650)
  16. Shafee MA, Fukuda K, Wakayama Y, Nakano M, Hasebe Y, Kondo M, Shimokawa H. Characteristics of patients with cardiac sarcoidosis presenting primarily with ventricular arrhythmias. (#14529)
  17. Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H. ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice. (#9348)
  18. Shiroto T, Sugiyama T, sartoretto J, Kalwa H, Shimokawa H, Michel T. A key role for caveolin-1 in the regulation of oxidative stress. (#10814)
  19. Suzuki H, Sumiyoshi A, Kawashima R, Shimokawa H. Evidence for different brain processing from the left and the right ventricles by brain functional MRI in rats. (#11313)
  20. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H, on Behalf of the Japanese Coronary Spasm Association Novel clinical risk score for the prediction of cardiac events in patients with vasospastic angina -A report from the nationwide multi-center registry by the Japanese Coronary Spasm Association- (#9877)
  21. Takahashi J, Yasuda S, Shiba N, Miyazaki M, Shimokawa H. Continuous renal replacement therapy for the treatment of acute decompensated heart failure and cardio-renal syndrome. (#12107)
  22. Tanaka S, Nochioka K, Fukumoto Y, Shiba N, Miyoshi J, Williams CL, Liao JK, Shimokawa H. Crucial role of SmgGDS in the molecular mechanisms of the pleiotropic effects of HMG-CoA reductase inhibitors. (##9653)
  23. Yada T, Shimokawa H, Hiramatsu O, Goto M, Ogasawara Y, Kajiya F. Important role of endogenous hydrogen peroxide during angiotensin type 1 receptor blockers administration in pacing-induced metabolic coronary vasodilatation in dogs in vivo. (#10892)
2011年8月27〜31日,European Society of Cardiology 2011 (Paris, France)

<YIA, Clinical Science>

  1. Takagi Y, Yasuda S, Ogata Y, Sumiyoshi T, Goto T, Tanabe Y, Sueda S, Ogawa S, Ogawa H, Shimokawa H. Clinical implications of provocative tests of coronary vasospasm; safety, arrhythmic complication and type of spasm -A report from the multi-center registry by the Japanese coronary spasm association.

<Regular papers>

  1. Miura M, Shiba N, Nochioka K, Kohno H, Sugaya M, Shimokawa H. Albuminuria predicts the mortality in heart failure patients with preserved ejection fraction independent of glomerular filtration rate -An interim analysis of the CHART-2 study-
  2. Yamamoto S, Fukumoto Y, Sugimura K, Sato K, Miura Y, Tatebe S, Nakano M, Oikawa M, Ishii T, Shimokawa H. Intensive immunosuppressive therapy improves pulmonary hemodynamics and prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease.
  3. Aizawa K, Yasuda S, Takahashi J, Takii T, Kikuchi Y, Ito Y, Ito K, Nakayama M, Takeda M, Shimokawa H. Involvement of Rho-kinase activation in the pathogenesis of coronary hyperconsrtricting responses by drug-eluting stents in patients with coronary artery disease.
  4. Kikuchi Y, Aizawa K, Yasuda S, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H. Rho-kinase activity in circulating neutrophils of patients with vasospastic angina -Non-invasive method for diagnosis and disease activity assessment-
  5. Sugimura K, Fukumoto Y, Satoh K, Miura Y, Tatebe S, Yamamoto S, Shimokawa H. Marked effectiveness of percutaneous transluminal pulmonary angioplasty in patients with distal-type chronic thromboembolic pulmonary hypertension.
  6. Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Yamamoto S, Shimokawa H. Optical coherence tomography is superior to intravenous ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension.
  7. Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Nochioka K, Yamamoto S, Shimokawa H. Clinical characteristics and prognosis of patients with post-capillary reactive pulmonary hypertension caused by left heart disease.
  8. Matsumoto Y, Adams V, Linke A, Mangner N, Woitek F, Shimokawa H, Schuler G. Regular exercise prevents the development and rupture of experimental aortic aneurysm by inhibiting oxidative stress and proteolysis.
2011年5月9日,International Society of MR Medicine (ISMRM) (Montreal, Canada)
  1. Ota H, Oikawa M, Takeda M, Yasuda S, Takahashi J, Ito Y, Fukumoto Y, Higano S, Takahashi S, Shimokawa H. Carotid plaque MRI characteristics as a marker of severe coronary artery disease.
2011年4月15日,EuroPrevent 2011 Congress (Geneva, Swizterland)
  1. *Shimokawa H. New insights into cardiovascular prevention and rehabilitation: From bench to bedside.
2011年4月13日,Invited Lecture at the Headquarter of Storz Medical (Zurich, Swizterland)
  1. *Shimokawa H. Clinical applications of shock wave. -Potential wide indications-
2011年4月4日,Ground Round Lecture at University Hospital Zurich (Zurich, Swizterlands)
  1. *Shimokawa H. Development of extracorporeal cardiac shock wave therapy for ischemic heart disease.

研究業績一覧へ |このページのTOPへ

2010年 (*招待講演)
2010年2月26日〜28日,International Congress of Cardiology (Hong Kong)
  1. * Shimokawa H. Extracorporeal cardiac shock wave therapy.
2010年3月25日〜26日,42nd Scientific Meeting of the Heart Association of Thailand(Thailand)
  1. * Shiba N. Chronic heart failure in Japan : Implications from the CHART Studies.
2010年4月16日〜17日,The 5th Asian Pacific Congress of Heart Failure (Busan, Korea)
  1. * Shimokawa H. Pulmonary hypertension : Pathophysiology and therapeutic target.
2010年5月13日〜16日,20th World Congress of ISHR (Kyoto)

<Symposium : Cardio-renal interaction in heart failure>

  1. Kagaya Y, Wang W, Asaumi Y, Takeda M, Shimokawa H. Role of erythropoietin/erythropoietin receptor system in heart failure induced by left ventricular pressure overload

<Symposium : Vulnerable plaque and aborted rupture>

  1. * Shimokawa H. Mechanisms and pathophysiology of plaque unstabilization.

<Symposium : Lessons from genetically engineered animals lacking all NO synthases>

  1. Tsutsui M, Shimokawa H, Yanagihara N, Otsuji Y.

<Regular papers>

  1. Doe Zhulangigige, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Hoshikawa Y, Nawata J, Kondo T, Shimokawa H. Direct evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.
  2. Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Ishii N, Sugamura K, Shimokawa H. Genetic deletion of OX40 ligand suppresses the development of atherosclerosis in apolipoprotein E-deficient mice.
  3. Satoh K, Nigro P, Fukumoto Y, Blaxall BC, Berk BC, Shimokawa H. Cyclophilin A augments ROS production and angiotensin II-induced cardiac hypertrophy in mice.
  4. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Yi GJ, Ito K, Shimokawa H. Long-term treatment with eicosapentaenoic acid suppresses ischemia-induced ventricular fibrillation in pigs in vivo. -Possible involvement of ATP-sensitive potassium channel inhibition-
  5. Wang A, Kagaya Y, Asaumi Y, Fukui S, Takeda M, Shimokawa H. Recombinant human erythropoietin protects the heart from pressure overload-induced left ventricular dysfunction in mice in vivo.
2010年5月14日〜19日,2010 International Conference of American Thoracic Society (New Orleans, USA)
  1. Miura Y, Fukumoto Y, Nakano M, Satoh K, Sugimura K, Oikawa M, Shimokawa H. New additional prognostic factors of pulmonary hypertension -Lessons from long-term follow-up study-
  2. Sugimura K, Fukumoto Y, Oikawa M, Satoh K, Nakano M, Miura H, Shimokawa H. Diagnostic usefulness of vasodilator test with inhaled nitric oxide in patients with pulmonary veno-occlusive disease.
2010年6月14日〜18日,The 6th International Conference on Biology, Chemistry, and Therapeutic Applications of Nitric Oxide (Kyoto, Japan)

<YIA competition: The First Place>

  1. Satoh K, Nigro P, Berk BC, Shimokawa H. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis. Nitric Oxide. 22:S31,2010.

<Luncheon seminar>

  1. * Shimokawa H. Recent progress in the treatment of pulmonary hypertension. Nitric Oxide. 22:S39,201./li>

<Evening seminar>

  1. Tsutsui M, Shimokawa H, Yanagihara N, Otsuji Y. New insights from genetivcally manuplated mice lacking all NOSs. Nitric Oxide. 22:S41,2010.

<Regular papers>

  1. Hosoya M, Sawada A, Ohashi J, Takaki A, Shimokawa H. Combination therapy with an angiotensin receptor blocker and a calcium channel blocker improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice. Nitric Oxide. 22:S56,2010.
  2. Ito Y, Ito K, Shiroto T, Tsuburaya R, Gao JY, Takeda M, Fukumoto Y, Ysuda S, Shimokawa H. Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo -Involvement of NO-mediated mechanism- Nitric Oxide. 22:S901,2010.
  3. Matsumoto Y, Shimokawa H, Adams V. Regular exercise training prevents cardiac aortic valve disease in mice: potential importance of the valvular endothelial cells for the management of vavular heart disease. Nitric Oxide. 22:S16-17,2010.
  4. Ohashi J, Takaki A, Sawada A, Noda K, Hosoya M, Yada T< Shimokawa H. Mechanisms for the diverse roles of endothelial nitric oxide synthases between conduit and resistance arteries in mice. Nitric Oxide. 22:S55,2010.
  5. Yada T, Shimokawa H, Hiramitsu O, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Effects of endogeneous hydrogen peroxide and erythropoietin during acute coronary occlusion in canine coronary native collateral microcirculation in vivo. Nitric Oxide. 22:S63,2010.
2010年7月19日〜23日,The 16th World Congress on Basic and Clinical Pharmacology (Copenhagen, Denmark)

<Symposium : Cardioprortection by narural products>

  1. * Shimokawa H. Fish oil and ω3-unsaturated fatty acid.
2010年8月28日〜9月1日,European Society of Cardiology Congress 2010 (Stockholm, Sweden)

<Mini-Satellite Symposium>

  1. * Shimokawa H. Non-invasive revascularization by CSWT in chronic ischaemia: animal trial and randomized placebo-controlled clinical studies.

<ESC-JCS Joint Symposium : Vasoconstriction in ischemic heart disease>

  1. * Shimokawa H. New therapeutic option.

<Regular papers>

  1. Takagi Y, Yasuda S, Takahashi J, Takeda M, Nakayama M, Ito K< Hirose M, Wakayama Y, Fukuda K, Shimokawa H. Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in the decision-making for the management of patients with out-of-hospital cardiac arrest.
  2. Tatebe S, Fukumoto Y, Sugimura K, Nakano M, Miyauchi S, Satoh K, Oikawa M, Shimokawa H. Optical coherence tomography as a novel differential diagnostic tool for chronic thromboembolic pulmonary hypertension from pulmonary arterial hypertension.
2010年10月7日〜9日,The 54th Annual Scientific Meeting of the Korean Society of Cardiology (Seoul, Korea)

<Plenary lecture>

  1. * Shimokawa H. Rho-kinase as a new therapeutic target in cardiovascular medicine.
2010年11月13日〜17日,American Heart Association Scientific Sessions (Chicago, USA)
  1. Gao JY, Yasuda S, Tsuburaya R, Ito Y, Aizawa K, Kikuchi Y, Ito K, Shimokawa H. Long-term treatment with eicosapentaenoic acid ameliorates myocardial ischemia-reperfusion injury in pigs in vivo -A potential role of Rho-kinase pathway-
  2. Kikuchi Y, Aizawa K, Yasuda S, Tsuburaya R, Ito Y, Nakayama M, Takeda M, Ito K, Takahashi J, Shimokawa H. Enhanced Rho-kinase activity in circulating neutrophils in patients with vasospastic angina -Possible usefulness for diagnosis and disease activity assessment-
  3. Miyamichi S, Fukumoto Y, Sugimura K, Satoh K, Nakano M, Miura Y, Tatebe S, Oikawa M, Ishii T, Shimokawa H. Intensive immunosuppressive therapy improves pulmonary hemodynamics in patients with pulmonary arterial hypertension associated with connective tissue disease.
  4. Nakajima S, Ohashi J, Sawada A, Noda K, Shimokawa H. Evidence for the important role of the bone marrow in modulating microvascular endothelial functions in mice.
  5. Nakayama M, Osaki S, Shimokawa H. Validation of the mortality risk stratification models for cardiovascular disease
  6. Ohashi J, Sawada A, Takaki A, Noda K, Hosoya M, Shimokawa H. Calcium/calmodulin-dependent protein kinase kinase β (CaMKKβ) plays a key role for the diverse functions of endothelial nitric oxide synthases system between conduit and resistance arteries in mice.
  7. Satoh K, Fukumoto Y, Sugimura K, Tatebe S, Miura Y, Miyamichi S, Nakamura K, Nigro P, Berk BC, Shimokawa H. Cyclophilin A mediates pulmonary vascular remodeling by Rho-kinase activation in patients with pulmonary hypertension.
  8. Serizawa F, Ito K, Shimokawa H. Non-invasive extracorporeal shock wave therapy ameliorates walking ability in patients with peripheral artery disease and intermittent claudication.
  9. Shimizu T, Satoh K, Tanaka S, Fukumoto Y, Shimokawa H. ROCK2 in vascular smooth muscle cells plays a crucial role for hypoxia-induced pulmonary hypertension in mice.
  10. Takagi Y, Yasuda S, Takahashi J, Tsuburaya R, Ito Y,Morihiko Takeda M, Ito K, Wakayama Y, Fukuda K, Sugi M, Shimokawa H. Usefulness of dual induction tests for coronary vasospasm and ventricular fibrillation for iIndividualized treatment of survivors from out-of-hospital cardiac arrest without structural heart disease.
  11. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Arrhythmic Complications of coronary spasm provocation tests and its prognostic impact in patients with vasospastic angina -A report from the nationwide multi-center registry by the Japanese Coronary Spasm Association-.
  12. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Patients with vasospastic angina survived from out-of-hospital cardiac arrest as a high-risk population for major adverse cardiac events -A report from the nationwide multi-center registry by the Japanese Coronary Spasm Association-
  13. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Variant angina is associated with a higher incidence of MACE in patients with vasospastic angina -A report from the nationwide multi-center registry by the Japanese Coronary Spasm Association-.
  14. Takahashi K, Satoh K, Shimizu T, Yamaki N, Tanaka S, Berk BC, Shimokawa H. Combination therapy with amlodipine and atrovastatin prevents abdominal aortic aneurysm formation induced by angiotensin II in ApoE-deficient mice.
  15. Tatebe S, Fukumoto Y, Sugimura K, Satoh K, Miura Y, Miyamichi S, Oikawa M, Shimokawa H. Clinical characteristics and prognostic impacts of post-capillary reactive pulmonary hypertension in patients with left heart disease.
  16. Tatebe S, Fukumoto Y, Sugimura K, Sato K, Nakano M, Miura Y, Miyamichi S, Simokawa H. Optical coherence tomography as a novel diagnostic tool for distal-type chronic thromboembolic pulmonary hypertension.
  17. Tsuburaya R, Yasuda S, Aizawa K, Gao JY, Ito Y, Shiroto T, Ito K, Ishibashi-Ueda H, Shimokawa H. Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo. -Possible involvement of Rho-kinase pathway-
  18. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Gao JY, Ito K, Shimokawa H. Chronic treatment with eicosapentaenoic acid suppresses ischemia-induced ventricular fibrillation through inhibiting myocardial KATP channel in pPigs in vivo.
  19. Tsutsui M, Furuno Y, Morishita T, Yanagihara N, Shimokawa H, Otsuji Y. Accelerated vascular lesion formation in mice lacking all nitric oxide synthases: contribution of bone marrow cells.
  20. Tsutsui M, Morishita N, Nomura M, Sabanai K, Watanabe S, Matsumoto T, Shimokawa H, Shirahara A, Yanagisawa N. Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal remodeling in mice in vivo.
  21. Tsutsui M, Shibata K, Yatera Y, Furuno Y, Yanagihara N, Shimokawa H, Otsuji Y. Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases.
  22. Yada T, Shimokawa H, Hiramatsu O, Goto M, Ogasawara Y, Kajiya F. Angiotensin receptor blocker enhances H2O2-induced coronary collateral vasodilatation and improves diabetes-induced microvascular endothelial dysfunction in canine coronary collateral circulation in vivo.
  23. Yada T, Shimokawa H, Hiramatsu O, Sato M, Kashihara N, Takaki A, Goto M, Ogasawara Y, Kajiya F. Cardioprotective role of hydrogen peroxide and erythropoietin during acute coronary occlusion in canine native coronary collateral microcirculation in vivo.
2010年11月20日〜21日,Fourth Scientific Meeting of the Asian Society for Vascular Biology (Hong Kong)

<Paul M. Vanhoutte Research Symposium>

  1. * Shimokawa H. Endothelial research for 25 years: From regenerated endothelium to triple NOSs-deficient mice.

<YIA competition>

  1. Satoh K, Nigro P, Berk BC, Shimokawa H. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis and plaque rupture.

<Regular papers>

  1. Ohashi J, Sawada A, Takaki A, Noda K, Nakajima S, Hosoya M, Shimokawa H. Calcium/calmodulin-dependent protein kinase beta plays a key role for the diverse functions of endothelial nitric oxide synthases system between conduit and resistance arteries in mice.
  2. Sato K, Shimokawa H. Emerging importance of the erythropoietin receptor system and cyclophilin A as novel therapeutic targets in cardiovascular medicine.

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2009年 (*招待講演)
2009年3月4日,Invited Lecture at the University of Hong Kong (HK)
  1. * Shimokawa H. Rho-kinase as a novel therapeutic target for pulmonary arterial hypertension.
2009年4月29日〜5月1日,Arteriosclerosis, Thrombosis, and Vascular Biology 2009 Scientific Sessions (Washington D.C.)
  1. Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Shimokawa H. differential roles of progenitor cells in the pathogenesis of cardiovascular diseases.
2009年5月20日〜23日,The 17th Asian Pacific Congress of Cardiology (Kyoto)
  1. Yasuda S, Ogawa H, Shimokawa H. Prevalence and current practice of vasospastic angina in Japan.
2009年6月1日〜3日,10th International Symposium on Mechanisms of Vasodilatation (Matsushima)

<Symposium : Remodeling>

  1. Satoh K, Fukumoto Y, Nakano M, Sugimura K, Oikawa M, Nawata J, Demachi J, Shimokawa H. Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.

<Symposium : Pathophysiology>

  1. Nakata S, Tsutsui M, Shimokawa H, Shibata K, Yatera Y, Suda O, Yanagihara N, Otsuji Y. Critical role of renin-angiotensin- aldosterone axis in the pathogenesis of acute myocardial infarction in mice lacking entire nitric oxide synthase system.

<YIA competition (YIA受賞)>

  1. Doe Zhulangigige, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Hoshikawa Y, Nawata J, Kondo T, Shimokawa H. Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension.

<Regular papers>

  1. Furuno Y, Tsutsui M, Shimokawa H, Morishita T, Shibata K, Yatera Y, Otsuji Y, Tamura M, Yanagihara N.Vascular protective role of nitric oxide synthase system against vascular lesion formation in mice in vivo.
  2. Hosoya M, Takaki A, Sawada A, Ohashi J, Shimokawa H. Combination therapy with angiotensin receptor blocker and calcium channel blocker improves EDHF-mediated responses in diabetic apolipoprotein E-deficient mice.
  3. Ito Y, Ito K, Shiroto T, Tsuburaya R, Gao JY, Kikuchi Y, Aizawa K, Takeda M, Yasuda S, Shimokawa H. Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo.
  4. Miura Y, Fukumoto Y, Nakano M, Satoh K, Sugimura K, Oikawa M, Shimokawa H. New addi-tional prognostic factors of pulmonary hypertension─Lessons from long-term follow-up study─
  5. Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Shimokawa H. Different role of bone mar-row-derived progenitor cells in the pathogenesis of vascular disease.
  6. Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Ishii N, Suhgamura K, Shimokawa H. Genetic deletion of OX40 ligand suppresses the development of atherosclerosis in apolipoprotein E-deficient mice.
  7. Nakayama M, Yamaki N, Takeda M, Asaumi Y, Komaru T, Shimokawa H. Transcriptomic analy-sis for cardiac hypertrophy.
  8. Ohashi J, Takaki A, Morikawa K, Murayama Y, Yamagishi H, Hosoya M, Shimokawa H. Roles of endothelial oxidases in endothelium- derived hyperpolarizing responses in mice.
  9. Satoh K, Nigro P, Matoba T, Berk BC, Shimokawa H. Cyclophyllin A promotes vascular oxi-dative stress and accelerates development of angiotensin II-induced aortic aneurysms.
  10. Shiroto T, Yasuda S, Tsuburaya R, Ito Y, Takahashi J, Ito K, Ishibashi-Ueda H, Shimokawa H. Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by paclitaxel-eluting stent.
  11. Suda O, Tsutsui M, Shimokawa H, Nakata S, Morishita T, Sabanai K, Yanagihara N, Ostuji Y. Characterization of vascular function in mice lacking entire nirric oxide synthase system.
  12. Takagi Y, Yasuda S, Takahashi J, Takeda M, Nakayama M, Ito K, Hirose M, Wakayama Y, Fukuda K, Shimokawa H. Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients survided from out-of-hospital cardiac arrest.
  13. Wang W, Kagaya Y, Asaumi Y, Fukui S, Takeda M, Shimokawa H. Exogeneous erythropoietin protects left ventricle against pressure overload-induced dysfunction in mice.
  14. Yada T, Shimokawa H, Hiramatsu O, Goto M, Ogasawara Y, Kajiya F. Role of hydrogen peroxide, an endogeneous EDHF, during coronary occlusion and injection of erythropoietin in canine coronary native collaretal microcirculation.
2009年6月1日〜4日,XV International Symposium on Atherosclerosis (Boston)
  1. Nakano M, Fukumoto Y, Satoh K, Ishii N, Sugamura K, Shimokawa H. Genetic deletion of OX40 ligand suppresses the development of atherosclerosis in Apolipoprotein E-deficient mice.
  2. * Shimokawa H. Rho-kinase is an important therapeutic target in cardiovascular medicine.
  3. Shiroto T, Yasuda S, Tsuburaya R, Ito Y, Takahashi J, Ito K, Ishibashi-Ueda H, Shimokawa H. Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by paclitaxel-eluting stent.
2009年8月29日〜9月2日,European Society of Cardiology Congress 2009 (Barcelona, Spain)
  1. * Shimokawa H. Non-invasive revascularization by CSWT in chronic ischemia ; animal and clinical studies.
2009年11月14日〜18日,American Heart Association Scientific Sessions (Orlando, USA)

<Cardiovascular Seminar : The Role of Coronary Microvascular Dysfunction in Cardiac Diseases>

  1. * Shimokawa H. Endothelial function and dysfunction.
  2. Fukuda K, Shimokawa H. Different electrophysiological characteristics between patients with Brugada syndrome and those with idiopathic ventricular fibrillation.
  3. Nakano M, Shimokawa H. Genetic deletion of OX40 ligand suppresses the development of atherosclrosis in Apolipoprotein E-deficient mice.
  4. Oikawa M, Shimokawa H. Usefulness of cardiac resonance imaging in the clinical risk stratification in patients with hypertrophic cardiomyopathy.
  5. Takagi Y, Yasuda S, Shimokawa H. Emerging roles of coronary vasospasm and venrtricular fibrillation in the pathogenesis of out-of-hospital cardiac arrest.
  6. Takagi Y, Yasuda S, Shimokawa H, Ogawa H. Prognsotic significance of life-threatening arrhythmias during spontaneous attack of vasospastic angina Multixcenter registry study of the Japanese Coronary Spasm Association-
  7. Takahashi J, Shiba N, Shimokawa H. Undernutrition is an important prognostic factor of cardiac death in patients with diastolic heart failure.
  8. Takii T, Yasuda S, Shimokawa H. Incresing trend of the incidence of acute myocardial infarction over 30 years in Japan : Lessons from the MIYAGI-AMI Registry Study.
  9. Shiroto T, Yasuda S, Shimokawa H. Rho-kinase pathway plays an important role in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stsnts in pigs in vivo.
  10. Wang W, Kagaya Y, Shimokawa H. Cardioprotective effects of exogeneous erythropoietin in pressure overload-induced left ventricular dysfunction in mice.
  11. Yada T, Shimokawa H, Kajiya F. Cardioprotective effects of hydrogen peroxide and ery-thro-poietin during acute coronary occlusion in canine coronary native collateral microvessels in vivo.
2009年11月15日,Meet the Specialist in AHA (Orland, USA)
  1. Yasuda S. The pathological significance of coronary vasomotion impairments ; Insights from DES-implanted pig model and survivors from out-of-hospital cardiac arrest.
2009年12月7日〜8日,The 1st International Global COE Symposium (Sendai, Japan)
  1. Hosoya M, Shimokawa H. Combination therapy with an angiotensin receptor blocker and a calcium channel blocker improves EDHF-mediated responses in diabetic Apolipoprotein E-deficient mice.
  2. Nakano M, Satoh K, Fukumoto Y, Ito Y, Kagaya Y, Ishii N, Sugamura K, Shimokawa H. Important role of erythropoietin receptor to promote vascular endothelial growth factor expression and angiogenesis in peripheral ischemia in mice.
  3. Ohashi J, Takaki A, Sawada A, Noda K, Hosoya M, Shimokawa H.Molecular mechanisms for the different functions of endothelial nitric oxide synthase system in mice.
  4. * Shimokawa H.Important roles of endothelium-derived reactive oxygen species in cardio-vascular and metabolic regulation.

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2008年 (*招待講演)
2008年3月19日,The 1st International Workshop on Pulmonary Hypertension in Tohoku University(Sendai, Japan)
  1. Fukumoto Y, Shimokawa H. Rho-kinase is a novel therapeutic target in pulmonary arterial hypertension.
  2. Miura Y, Fukumoto Y, Fukui S, Sugimura K, Jun Nawata, Shimokawa H. Thyroid dysfunction in patients with pulmonary hypertension.
  3. Nakano M, Satoh K, Fukumoto Y, Sugimura K, Nawata J, Demachi J, Karibe A, Kagaya Y, Watanabe J, Shirato K, Ishii N, Sugamura K, Shimokawa H. Pravastatin ameliorates hypoxia-induced pulmonary arterial hypertension associated through down-regulation of stromal cell-derived factor-1 in mice.
  4. Sugimura K, Fukumoto Y, Nawata J, Saji K, Fukui S, Miura Y, Shimokawa H. The impact of dilatation of pulmonary artery on the prognosis of patients with pulmonary arterial hypertension.
  5. Tawara S, Abe K, Morikawa K, Fukumoto Y, Shimokawa H. Prostacyclin lacks inhibitory effects on Rho-kinase -Possible effects of combined therapy with prostacyclin and Rho-kinase inhibitor in pulmonary hypertension.
  6. Zhulangigige Do. E, Fukumoto Y, Nawata J, Tawara S, Nakano M, Tada T, Saji K, Fujita H, Hoshikawa Y, Kondo T, Shimokawa H. Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. (Best abstract award受賞)
2008年5月17日〜22日,8th Meeting of the International Society for the Study of Fatty Acids & Lipids (Kansas City, Missouri, USA)
  1. Yasuda S, Sawano H, Hazui H, Ukai I, Yokoyama H, Ohashi J, Sase K, Kada A, Nonogi H; J-PULSE Investigators. High rates of survival to hospital admission in patients with shock-resistant out-of-hospital ventricular fibrillation treated with nifekalant hydrochloride, a novel and pure class-III agent: Report from J-PULSE registry. American Heart Association Resuscitation Science Symposium 2008. P 70 (p 178)
  2. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Gao J, Ito K, Shimokawa H. Long-term treatment with eicosapentaenoic acid suppresses ischemia-induced ventricular fibrillation in pigs- Evaluation with monophasic action potential.
2008年6月24日〜27日,5th International EDHF Symposium (Tampere, Finland)
  1. * Shimokawa H. Divergent roles of endothelial NO synthases system in the orchestrated interplay between endothelium and vascular smooth muscle.
2008年8月1日〜3日,3rd Scientific Meeting of Asian Society for Vascular Biology (Singapore)
  1. * Shimokawa H. Rho-kinase is an important therapeutic target for the treatment of pulmonary arterial hypertension.
2008年8月30日〜9月3日,European Society of Cardiology Congress 2008 (Munich, Germany)
  1. Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Sugimura K, Shinozaki T, Kagaya Y, Shimokawa H. Diabetes mellitus exacerbate left ventricular diastolic dysfunction through activation of rennin-angiotensin system in hypertensive rats.
  2. Ito Y, Ito K, Shiroto T, Tsuburaya R, Gao JY, Yasuda H, Shimokawa H. Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo.
2008年11月8日〜12日,Annual Scientific Meeting of the American Heart Association (New Orleans)
  1. Doe Z, Fukumoto Y, Takaki A, Tawara T, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Nawata J, Hoshikawa Y, Kondo T, Shimokawa H. Evidence for Rho-kinase activation in patients with pulmonary hypertension. E0145Circulation. 118(Suppl II):S-446,2008.
  2. Fukuda K, Wakayama Y, Hirose M, Yamaguchi N, Kondo M, Shimokawa H. Blocking of sodium channels reveals the regional endocardial substratein Brugada syndrome. E0145Circulation. 118(Suppl):S-981-982,2008.
  3. Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Sugimura K, Miura Y, Kagaya Y, Shimokawa H. Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of renin-angiotensin system in hypertensive rats. E0145Circulation. 118(Suppl II):S-439,2008.
  4. Ito Y, Ito, K, Shiroto T, Tsuburaya R, Gao J, Kikuchi Y, Aizawa K, Takeda M, Yasuda S, Shimokawa H. Extracorporeal cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs. E0145Circulation. 118(Suppl II):S-291,2008.
  5. Miura M, Nishio T, Shindoh C, Shimokawa H. Maintenance of triggered arrhythmias by non-uniform excitation-contraction coupling in rat cardiac muscle. E0145Circulation. 118(Suppl II):S-438,2008.
  6. Nakayama M, Yamaki N, Takeda M, Shimokawa H. Clustering transcriptional network is useful to characterize heart failure models. E0145Circulation. 118(Supp II):S-276,2008.
  7. Shiroto T, Yasuda S, Tsuburaya R, Ito Y, Ishibashi-Ueda H, Ito K, Takahashi J, Shimokaw H. Rho-kinase pathway plays an important role in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stent. E0145Circulation. 118(Suppl II):S-893,2008.
  8. Takaki A, Morikawa K, Murayama Y, Tekes E, Yamagishi H, Ohashi J, Tsutsui M, Yada T, Yanagihara N, Shimokawa H. Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. E0145Circulation. 118(Suppl II):S-454,2008.
  9. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Gao J, Ito K, Shimokawa H. Long-term treatment with eicosapentaenoic acid suppresses ischemia-induced ventricular fibrillation: Potential involvement of ATP-sensitive potassium (KATP) channel. E0145Circulation. 118(Suppl II):S-1137,2008.
  10. Tsutsui M, Yatera Y, Shimokawa H, Nakata S, Shibata K, Morishita T, Sabanai K, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. A new animal model of hypercholesterolemia and atherosclerosis: Mice deficient in all nitric oxide synthases. E0145Circulation. 118(Suppl II) : S-521. 2008.
  11. Tsutsui M, Nakata S, Shimokawa H, Shibata K, Yatera Y, Suda O, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Complete deletion of all nitric oxide synthase genes causes activation of the renin-angiotensin-aldosterone axis in mice in vivo. E0145Circulation. 118(Suppl II):S-303,2008.
  12. Tsutsui M, Morisada N, Nomura M, Sabanai K, Watanabe S, Matsumoto T, Shimokawa H, Shirahata A, Yanagihara N. Genetic disruption of all nitric oxide synthase isoforms causes accelerated renal lesion formation in mice in vivo. E0145Circulation. 118(Suppl II):S-335,2008.
  13. Tsutsui M, Shibata K, Shimokawa H, Yatera Y, Furuno Y, Nakata S, Sabanai K, Morishita T, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthase isoforms. E0145Circulation. 118(Suppl II):S-422,2008.
  14. Yada T, Shimokawa H, Hiramatsu O, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Crucial role of hydrogen peroxide as an endogenous EDHF during acute coronary occlusion and injection of erythropoietin in canine coronary native collateral microcirculation in vivo. E0145Circulation. 118(Suppl II):S-504,2008.
2008年11月13日,Invited Lecture at the University of South Alabama as a visiting professor (Mobile)
  1. * Shimokawa H. Rho-kinase inhibitors: Novel vasodilators with potential therapeutic use in pulmonary hypertension.
2008年11月14日,Invited Lecture at the Medical College of Wisconsin as a visiting professor (Milwaukee)
  1. * Shimokawa H. New thoughts on the interplay between the endothelium and vascular smooth muscle. ―NO synthases system and Rho-kinase―

研究業績一覧へ |このページのTOPへ

2007年 (*招待講演)
2007年11月10日〜14日,Annual Symposium of the American Medical Informatics Association(Chicago, USA)
  1. Nakayama M, Kondo Y. An XML-based integration method for different types of patient data in cardiology.
2007年11月4日〜7日,Annual Scientific Meeting of the American Heart Association(Orland, USA)
  1. Fukuda K, Kumagai K, Wakayama Y, Sugai Y, Hirose M, Yamaguchi N, Shimokawa H. Pilsicainaide, a pure sodium channel blocker, enhances the arrtythmogenic endocardial substrate in Burgada syndrome. Circulation. 116(Suppl II):II-389,2007.
  2. Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Tawara S, Shinozaki T, Kagaya Y, Shimiokawa H. Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats. Circulation. 116(Suppl II):II-124-125,2007.
  3. Hirose M, Stuyvers B, Dun W, Shimokawa H, ter Keurs HEDJ, Boyden P. JTV-519(K201)reverses abnormal Ca2+ release and dynamic Ca2+ waves in Purkinje cells from the infracted canine heart. Circulation. 116(Suppl II):II-84,2007.
  4. Miura M, Wakayama Y, Shimokawa H. Ca2+ dissociated from myofilaments enhances delayed afterdepolarizations by triggering Ca2+ waves in rat cardiac muscle. Circulation. 116(Suppl II):II-277,2007.
  5. Nakano M, Satoh K, Fukumoto Y, Ito Y, Ishii N, Sugamura K, Shimokawa H. Inhibition of OX40 ligand suppresses the development of atherosclerosis in Apoprotein E-deficient mice. Circulation. 116(Suppl II):II-1-2,2007.
  6. Nakano M, Satoh K, Fukumoto Y, Sugimura K, Nawata J, Demachi J, Karibe A, Kagaya Y, Watanabe J, Shirato K, Ishii N, Sugamura K, Shimokawa H. Pravastatin ameliorates hypoxia-induced pulmonary arterial hypertension associated through down-regulation of stromal cell-derived factor-1 in mice. Circulation. 116(Suppl II):II-122,2007.
  7. Nakata S, Tsutsui M, Shimokawa H, Yatera Y, Shibata K, Morishita T, Sabanai K, Suda O, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Abnormal lipoprotein metabolism in mice lacking all nitric synthase isoforms. Circulation. 116(Suppl II):II-64,2007.
  8. Nakata S, Tsutsui M, Shimokawa H, Sabanai K, Yatera Y, Shibata K, Morishita T, Suda O, Tasaki H, Nakashima Y, Yanagihara Y, Otsuji Y. Disruption of whole nitric oxide synthase system impaired glucose tolerance in mive in vivo. Circulation. 116(Suppl II):II-795,2007.
  9. Nakata S, Tsutsui M, Shimokawa H, Suda O, Sabanai K, Yatera Y, Shibata K, Morishita T, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Gender difference of arteriosclerotic cardiovascular disease in mice lacking all nitric oxide synthase isoforms. Circulation. 116(Suppl II):II-309,2007.
  10. Nakata S, Tsutsui M, Shimokawa H, Morishita T, Sabanai K, Yatera Y, Suda O, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Important role of rennin-angiotensin system in the pathogenesis of myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation. 116(Suppl II):II-98,2007.
  11. Nakata S, Tsutsui M, Shimokawa H, Suda O, Sabanai K, Yatera Y, Shibata K, Morishita T, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Statin treatment ameliorates metabolic syndrome in mice lacking all nitric oxide synthase isoforms. Circulation. 116(Suppl II):II-174,2007.
  12. Takaki A, Morikawa K, Murayama Y, Tekes E, Tsutsui M, Yanagihara N, Shimokawa H. Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthase system―Lessons from mice lacking all nitrix oxide synthase isoforms―. Circulation. 116(Suppl II):II-263,2007.
  13. Talukder MAH, Nishimura Y, Bonagura JD, Kalyanasundaram A, Peroiasamy M, Shimokawa H, Zweier JL. Short-term treatment with DITPA, a thyroid hormone analog, improves postischemic coronary flow and cardiac contractile function in hypertensive endothelial nitric oxide synthase knockout(eNOS-KO)mice. Circulation. 116(Suppl II):II-199,2007.
  14. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Ito K, Soma M, Shimokawa H. Long-term treatment with eicosapentaenoic acid suppresses ventricular fibrillation in a porcine model of acute myocardial infarction: In vivo analysis using monophasic action potential. Circulation. 116(Suppl II):II-725,2007.
  15. Yada T, Shimokawa H, Hiramatsu O, Shimozali Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Protective role of hydrogen peroxide and erythropoietin during acute coronary occlusion/reperfusion in native coronary collateral circulation in dogs in vivo. Circulation. 116(Suppl II):II-29,2007.
  16. Yada T, Shimokawa H, Morikawa K, Takaki A, Shinozali Y, Mori H, Goto M, Kajiya F. Crucial role of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor(EDHF)during reactive hyperemia in mouse mesenteric microcirculation in mice. Circulation. 116(Suppl II):II-228,2007.
  17. Yasuda S, Miyazaki S, Nagaya N, Kataoka Y, Noguchi T, Morii I, Kawamura A, Kangawa K, Miyatake K. Feasibility of adrenomedullin infusion in patients with acute myocardial infarction-a possible cardioprotective therapy against ischemic injuury. Circulation. 116(Suppl II):II-3379,2007.
  18. Yatera Y, Tsutsui M, Shimokawa H, Nakata S, Shibata K, Morishita T, Sabanai K, Tasaki H, Nakashima Y, Yanagihara N, Otsuji Y. Severe dyslipidemia and lipid-rich atherosclerotic lsion formation in mice lacking all nitric oxide synthase fed a high-holesterol diet. Circulation. 116(Suppl II):II-508,2007.
2007年10月16日,6th International Conference on Bioelectromagnetism(Aizu, Japan)
  1. * Shimokawa H. Development of non-invasive extracorporeal cardiac shock wave therapy for the treatment of myocardial ischemia.
2007年8月31日〜9月5日,ESC Congress 2007(Vienna, Austria)
  1. Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Tawara S, Shinozaki T, Kagaya Y, Shimokawa H. Rho-kinase pathway plays an important role in the pathogenesis of diastolic heart failure in rats.
  2. Takahashi J, Shiba N, Tada T, Matsuki M, Shimokawa H. Undernutrition is an important prognostic factor of cardiac death in patients with diastolic heart failure.
2007年6月29日,Invited Lecture at the Hong Kong Pharmacological Society(Hong Kong, China)
  1. * Shimokawa H. Development of Rho-kinase inhibitors for cardiovascular medicine.
2007年6月24日〜27日,Europace 2007 Congress(Lisbon, Portugal)
  1. Fukuda K, Kumagai K, Wakayama Y, Sugai Y, Hirose M, Yamaguchi N, Shimokawa H. Pilsicainide, a pure sodium channel blocker unmasks the endocardial substrate in Brugada syndrome.
  2. Kumagai K, Fukuda K, Wakayama Y, Sugai K, Hirose M, Yamaguchi N, Shimokawa H. Characterization of idiopathic left ventricular tachycardia originating from the aortomitral continuity.
2007年6月10日,4th Scientific Symposium―Current Therapy for PAH and Future Perspective of Dual Endothelin Receptor Antagonism(ERA)(Kyoto, Japan)
  1. Fukumoto Y. How should we be careful to start bosentan.
2007年5月9日,the 28th Annual Scientific Sessions of the Heart Rhythm Society(Denver, USA)
  1. * Kumagai K. Ablation of idiopathic LVT at the mitral annulus.
2007年4月20日,Arteriosclerosis, Thrombosis, and Vascular Biology Scientific Session 2008(Chicago, USA)
  1. Nakano M, Satoh K, Fukumoto Y, Yoshitaka I, Kagaya Y, Shimokawa H. Important role of erythropoietin receptor to promote vascular endothelial growth factor expression and angiogenesis in peripheral ischemia in mice.
2007年3月25日,56th American College of Cardiology(New Orleans, USA)
  1. Nakayama M, Komaru T, Shimokawa H. Successful in vivo imaging of the enhanced transcriptional activity of GATA in the heart during the progression of angiotensin II-induced hypertrophy in mice.
2007年3月16日,The Myung-In Cardiovascular Lecture(Kobe, Japan)
  1. * Shimokawa H. Recent progress in the management of vasospstic angina.

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2006年 (*招待講演)
2006年4月27日〜29日,7th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, 2006 Jeffrey M. Hoeg ATVB Award Lecture(Denver, USA)
  1. * Shimokawa H. Translational research on the therapeutic importance of Rho-kinase in cardiovascular medicine.
2006年5月16日,Heart Rhythm 2006 (Boston, USA)
  1. * Kumagai K, Wakayama Y, Fukuda K, Sugai Y, Shimokawa H. A new approach for a non-pharmacological treatment of refractory ventricular tachycardia.
2006年6月14日〜17日,15th World Congress on Cardiac Electrophysiology and Cardiac Techniques (Nice, France)
  1. Kumagai K, Wakayama Y, Fukuda K, Sugai Y, Shimokawa H. Observation of bidirectional transverse conduction of the crista terminalis in patients with typical atrial flutter.
  2. Wakayama Y, Kumagai K, Oikawa M, Fukuda K, Sugai Y, Sugimura K, Kagaya Y, Kaneta T, Fukuda H, Shimokawa H. Cardiac resynchronization therapy improves non-uniform regional left ventricular wall thickening −Evaluation by quantitative gated myocardial perfusion spect−.
2006年6月27日,11th International Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia(Soochow, China)
  1. * Shimokawa H. Therapeutic importance of Rho-kinase in cardiovascular medicine.
2006年7月2日〜7日,The 15th World Congress of Pharmacology (Beijing, China)
  1. * Shimokawa H. Rho-kinase is an important therapeutic target in cardiovascular medicine.
2006年9月3日,World Congress of Cardiology (Barcerona, Spain)
  1. Shiba N, Tada T, Matsuki M, Kagaya Y, Shimokawa H. Poor nutritional status predicts the prognosis of patients with chronic heart failure.
2006年9月6〜9日,Grover Conference on the Pulmonary Circulation (Denver, USA)
  1. * Shimokawa H. Rho-kinase inhibitors in cardiovascular diseases.
  2. Fukumoto Y, Shimokawa H. Rho-kinase inhibitor, fasudil, reduces pulmonary vascular resistance in patients with severe pulmonary hypertension.
2006年9月8日,Invited Lecture at the Headquarter of CoTherix Co.(San Francisco, USA)
  1. * Shimokawa H. Rho-kinase is an important therapeutic target in cardiovascular medicine.
2006年10月15日〜19日,The 21st Scientific Meeting of the International Society of Hypertension(Fukuoka, Japan)
  1. Nawata J, Onoue N, Tada T, Wang H, Sugimura K, Shimokawa H. Increased static pressure promotes migration of vascular smooth muscle cells −Implication for atherogenesis in hypertension−.
  2. Tada T, Nawata J, Wang H, Onoue N, Sugimura K, Shimokawa H. Pulsatile pressure accelerates vascular smooth muscle migration through IP3-receptor.
  3. Takaki A, Morikawa K, Murayama Y, Ender T, Tsutsui M, Yanagihara N, Shimokawa H. Genetic disruption of all niric oxide synthase isoforms abolishes EDHF-mediated responses in mice.
  4. Takaki A, Morikawa K, Murayama Y, Shimokawa H. NAD(P)H oxidase-derived superoxide anions are not involved in endothelium-dependent hyperpolarizations mediated by hydrogen peroxide in mice.
2006年10月21日,International Symposium: The Kideny and Hypertension (Sendai, Japan)
  1. Shiba N, Matsuki M, Takahashi J, Tada T, Shimokawa H. Prognostic benefit of inhibition of renin-angiotensin system in patients with diastolic heart failure.
2006年11月12日〜15日,Annual Scientific Meeting of the American Heart Association (Chicago, USA)
  1. Arakawa K, Yasuda S, Hao H, Ueda H, Morii I, Kataoka Y, Kasahara Y, Kawamura A, Miyazaki S. Significant association between neutrophil in aspirated thrombus and myocardial damage in patients with ST-segment elevation acute myocardial infarction. Circulation. 114(Suppl II):II-595,2006.
  2. Asaumi Y, Kagaya Y, Yamaguchi N, Takeda M, Ito K, Ohta J, Tada H, Minegishi N, Shimokawa H. Important protective role of endogenous erythropoietin/erythropoietin-receptor system against pressure overload-induced left ventricular dysfunction in mice in vivo. Circulation. 114(Suppl II): II-151,2006.
  3. Ito K, Minatoya Y, Kagaya Y, Asaumi Y, Takeda M, Nakayama M, Takahashi J, Yahagi H, Iguchi A, Shirato K, Shimokawa H. Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded heart are ameliorated with low dose of thyroid hormone in rats. Circulation. 114(Suppl II):II-668,2006.
  4. Koiwa Y, Katoh T, Ishii T, Sasaki T, Shimokawa H. Successful real time evaluation of intramural inflammation of carotid artery with 2D elasticity image by high-resolution Doppler technique in patients with Takayasu arteritis. Circulation. 114(Suppl II):II-362,2006.
  5. Mori S, Yasuda S, Kataoka Y, Kasahara Y, Morii I, Kawamura A, Miyazaki S. Calcification in target lesion and stent delivery pathway as important determinant for coronary restenosis after sirolimus eluting stent implantation: Calcification score analysis. Circulation. 114(Suppl II):II-641,2006.
  6. Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Nakata S, Yatera Y, Tasaki H, Nakashima Y, Yanagihara N. Acelerated vascular lesion formation in mice lacking all nitric oxide sythases in vivo. Circulation. 114 (Suppl II):II-228,2006.
  7. Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Nakata S, Yatera Y, Tasaki H, Nakashima Y, Yanagihara N. Genetic disruption of all nitric oxide synthase isoforms markedly reduces survival due to myocardial infarction in male mice. Circulation. 114(Suppl II):II-273,2006.
  8. Nakano S, Tsutsui M, Shimokawa H, Morishita T, Sabanai K, Yatera Y, Tasaki H, Nakashima Y, Yanagihara N. Long-term treatment with an angiotensin II type 1 receptor blocker ameliorates metabolic syndrome in mice lacking all nitric oxide synthases. Circulation. 114(Suppl II):II-61,2006.
  9. Nakata S, Tsutsui M, Shimokawa H, Yatera Y, Morishita T, Sabanai K, Tasaki H, Nakashima Y, Yanagihara N. Hyper-low-density-lipoproteinemia in mice lacking all nitric oxide synthases. Circulation. 114(Suppl II): II-218,2006.
  10. Nakata S, Tsutsui M, Shimokawa H, Morishita T, Sabanai K, Yatera Y, Tasaki H, Nakashima Y, Yanagihara N. Metabolic syndrome in mice lacking all nitric oxide synthase isoforms. Circulation. 114(Suppl II): II-88,2006.
  11. Saga A, Karibe A, Otomo J, Takahashi T, Iwabuchi K, Kikuchi J, Shinozaki T, Shimokawa H. Prevalence of lamin A/C gene mutations in familial dilated cardiomyopathy with progressive atrioventricular block in Japan. Circulation. 114(Suppl II):II-194,2006.
  12. Satoh K, Nakano M, Ito Y, Fukumoto Y, Kagaya Y, Shimokawa H. Direct evidence for the important role of erythropoietin receptor to promote angiogenesis in peripheral ischemia in mice. Circulation. 114(Suppl II):II-229,2006.
  13. Shiba N, Tada T, Matsuki M, Watanabe J, Kagaya Y, Shimokawa H. Metabolic syndrome is a prognostic risk in patients with diastolic heart failure. Circulation. 114(Suppl II):II-853,2006.
  14. Shiba N, Tada T, Matsuki M, Kagaya Y, Shimokawa H. Prognostic importance of nutritional status in patients with chronic heart failure. Circulation. 114(Suppl II):II-899,2006.
  15. Shibata K, Tsutsui M, Shimokawa H, Morishita T, Yatera Y, Nakata S, Sabanai K, Yanagihara N, Nakashima Y. Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases. Circulation. 114(Suppl II):II-125,2006.
  16. Takaki A, Morikawa K, Murayama Y, Tekes E, Tsutsui M, Yanagihara N, Shimokawa H. Endothelium-dependent hyperpolarizations are totally dependent on endothelial nitric oxide synthases system ― Lessons from mice lacking all nitric oxide synthase isoforms ―. Circulation. 114(Suppl II):II-247,2006.
  17. Yada T, Shimokawa H, Hiramatsu O, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Crucial role of hydrogen peroxide as an endogenous endothelium-derived hyperpolarizing factor during pacing-induced metabolic dilatation in canine coronary microvessels in vivo. Circulation. 114(Suppl II):II-78,2006.
  18. Yasuda S, Miyazaki S, Hosoda H, Kataoka Y, Nagaya N, Morii I, Kawamura A, Nonogi H, Kangawa K. Decreased serum ghrelin level in patients with acute myocardial infarction: Its association with the infarct size and time-dependent recovery. Circulation. 114(Suppl II):II-900,2006.
  19. Yatera Y, Tsutsui M, Shimokawa H, Nakata S, Morishita T, Sabanai K, Tasaki H, Nakashima Y, Nanagihara N. Severe dyslipidemia, lipid-rich atherosclerotic lesion formation, and sudden death in mice lacking all nitric oxide synthases fed a high cholesterol diet. Circulation. 114(Suppl II):II-219,2006.
  20. Wakayama Y, Oikawa M, Kagaya Y, Kumagai K, Fukuda K, Sugai Y, Sugimura K, Kaneta T, Fukuda H, Sugimura K, Shinozaki T, Ogawa H, Fukui S, Shimokawa H. Usefulness of quantitative gated myocardial perfusion SPECT to evaluate the initial effectiveness of cardiac resynchronization therapy and to predict left ventricular reverse remodeling. Circulation. 114(Suppl II):II-637,2006.
2006年11月23日〜25日,Asia Pacific Atrial Fibrillation Symposium in Tokyo (Tokyo, Japan)
  1. Kumagai K, Wakayama Y, Fukuda K, Sugai Y, Shimokawa H. Effects of combined strategy of left atrial ablation and anti-arrhythmic drugs on reverse remodeling of left atrium in arial fibrillation.
2006年11月29日,The 4th Joint Meeting of the Acustical Society of America and the Acoustical Society of Japan(Hawaii, USA)
  1. * Shimokawa H. Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in animals and humans.
2006年12月1日,17th Genome Informatics Workshop (Yokohama, Japan)
  1. Nakayama M, Tada H, Asaumi Y, Shimokawa H. Cluster analysis of transcription factor binding sites in the promoter regions of cardiac genes in failing hearts.

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2005年
Europace 2005 (2005年7月27日,Praque, Czech Republic)
  1. Wakayam a Y,Oikawa M, Otani H, Otomo J, Kumagai K, Fukuda K, Baba S, Shinozaki T, Miura M, Kagaya Y, Watanabe J, Iguchi A, Tabayashi K, Kaneda T, Shirato K. Evaluation of cardiac resynchronization using gated mocardial perfusion single photon emission computed tomography.
European Society of Cardiology Congress (2005年9月3日,Stockholm, Sweden)
  1. Shimokawa H. Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.
The First Scientific Meeting of the Asian Society for Vascular Biology (2005年10月8日,Shanghai, China)
  1. Shimokawa H. Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans.
  2. Takaki A, Morikawa K, Tekes E, Murayama Y, Shimokawa H. NAD(P)H oxidase-derived superoxide anions are not involved in endothelium-dependent hyperpolarization meiated by hydrogen peroxide in angiotensin II-infused mice.
  3. Tekes E, Morikawa K, Takaki A, Murayama Y, Tsutsui M, Yanagihara N, Sunagawa K, Shimokawa H. Genetic disruption of all nitric oxide synthase isoforms abolishes EDHF-mediated responses in mice.
The 78th Scientific Sessions of American Heart Association (2005年11月14-16日, Dallas, TX, USA)
  1. Shiba N. Meta-analysis: do angiotensin-converting-enzyme inhibitors reduce non-cardiovacular mortality. Circulation 112(Suppl II) :II-791,2006.
  2. Satoh K, Karibe A, Shimizu A, Sakuma M, Kagaya Y, Watanabe J, Shirato K, Shimokawa H. Bone marrow-derived Flk-1-positive cells differentiate into distinct vascular lineages in hypoxia-induced pulmonary hypertension. Circulation 112(Suppl II):II-223,2006.
  3. Kokusho Y, Komaru T, Takeda S, Koshida R, Takahashi T, Nakayama M, Kanatsuka H, Shirato K. Hydrogen peroxide derived from beating heart mediates coronary microvascular dilation during tachycardia. Circulation 112(Suppl II):II-65,2006.
  4. Kumagai K, Wakayama Y, Fukuda K, Sugai Y, Shimokawa H. Two types of origin refractory to ablate from endocardium of idiopathic left ventricular tachyarrhythmia from the mitral annulus. Circulation 112(Suppl II) :II-576,2006.
  5. Tada T, Shiba N, Shinozaki T, Takahashi J, Watabnabe J. Anemia predicts sudden death in heart failure patients with preserved systolic function. Circulation 112(Suppl II):II-456,2006.
  6. Tada H, Takeda M, Ohta J, Asaumi Y, Itoh K, Satoh K, Karibe A, Shirato K, Kagaya Y. Endogenous erhythropoietin-erhythropoietin recetor signals in non-erhythroid lineage may contribute to increased plasma erhythropoietin level and prevention of cardiomocyte apoptosis after myocardial ischemia and repefusion. Circulation 112(Suppl II) :II-182,2006.
  7. Koiwa Y, Katoh G, Okimoto H, Ishigaki Y, Oka Y, Seiji K, Satoh K, Katoh M, Hagiwara H, Tanaka Y. The clinical assessment of the cross-sectional longitudinal elasticity distribution of plaque in the carotid artery. Circulation 112(Suppl II):II-428,2006.
  8. Nakata S, Tsutsui M, Shimokawa H, Morishita T, Sabanai K, Tasaki H, Yanagihara N, Nakashima Y. Atorvastatin upregulates vascular neuronal nitric oxide synthase through the Akt/NFkB pathway. Circulation 112(Suppl II):II-84,2006.
  9. Nagasaki M, Tsutsui M, Shimokawa H, Morishita T, Nakata S, Sananai K, Tasaki H, Yanagihara N. Spontaneous development of systemic arteriosclerosis in mice lacking all nitric oxide synthase isoforms. Circulation 112(Suppl II):II-166,2006.
  10. Yada T, Shimokawa H, Hiramatsu O, Goto M, Ogasawara Y, Shinozaki Y, Mori H. Role of hydrogen peroxide as an endogenous EDHF during pacing-induced metabolic dilatation in canine coronary microcircluation in vivo. Circulation 112(Suppl II):II-216,2006.
  11. Yada T, Shimokawa H, Hiramatsu O, Goto M, Ogasawara Y, Kajiya F, Mori H, Shinozaki Y. Cardioprotective role of hydrogen peroxide as an endogenous EDHF, during ischemia-reperfusion injury in canine coronary microcirculation in vivo. Circulation 112(Suppl II):II-217,2006.
  12. Hizume T, Morikawa K, Uwatoku T, Oi K, Abe K, Anegawa G, Shimokawa H. Sustained elevation of serum cortisol level enhances coronary vasospastic activity through Rho-kinase activation in pigs. Circulation 112(Suppl II) :II-235,2006.
  13. Tekes E, Morikawa K, Takaki A, Murayama Y, Tsutsui M, Yanagihara N, Shimokawa H. Genetic disruption of all nitric oxide synthase isoforms abolishes EDHF-mediated responses in mice. Circulation 112(Suppl II) :II-262,2006.
  14. Yada T, Shimokawa H, Morikawa K, Takaki A, Goto M, Ogasawara Y, Kajiya F. Crucial role of Cu/Zn-SOD in the synthesis of endothelium-derived hyperpolarizing factor (EDHF) during reactive hyperemia in mouse mesenteric microcirculation in vivo. Circulation 112(Suppl II):II-313,2006.

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