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英文原著論文

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2017年
  1. Nihei T, Yamamoto Y, Kudo S, Hanawa K, Hasebe Y, Takagi Y, Minatoya Y, Sugi M, Shimokawa H. Impact of the intracoronary Rendezvous technique on coronary angioplasty for chronic total occlusion. Cardiovasc Interv Ther. (in press)PDF
  2. Tokunaga H, Takahashi F, Yamamoto H, Honda T, Watanabe T, Shoji T, Sugiyama T, Yamada H, Tando T, Yoshinaga K, Kagabu S, Otsuki T, Kin S, Yokoyama Y, Wagatsuma S, Sato K, Sato H, Oishi T, Yoshida Y, Hayasaka T, Matsui T, Imai N, Nishigori H, Shimokawa H, Yaegashi N, Watanabe Y. Current status of uterine leiomyosarcoma in the Tohoku region: Results of the Tohoku Translational Center Development Network Survey. Int J Clin Oncol. 22:541-547,2017.PDF
  3. Kimura Y, Noda T, Matsuyama T, Otsuka Y, Kamakura T, Wada M, Ishibashi K, Inoue Y, Miyamoto K, Okamura H, Nagase S, Aiba T, Kamakura S, Noguchi T, Anzai T, Satomi K, Wada Y, Ohno S, Horie M, Shimizu W, Yasuda S, Shimokawa H, MD, Kusano K. Heart failure in patients with arrhythmogenic right ventricular cardiomyopathy: What are the risk factors? Int J Cardiol. 241:288-294,2017.PDF
  4. Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina S, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Matsuki H, Arasaki A, Tsutsui M. Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice. Diabetologia. 60:1138-1151,2017.PDF
  5. Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Elias-Al-Mamun M, AbdulHai Siddique MAH, Sunamura S, Nogi M, Suzuki K, Miyata S, John Morser J, Shimokawa H. Activated TAFI promotes the development of chronic thromboembolic pulmonary hypertension - A possible novel therapeutic target - Circ Res. 120:1246-1262,2017.PDF
  6. Onose T, Sakata Y, Nochioka K, Miura M, Yamauchi T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Miyata S, Takahashi J, Shimokawa H; the CHART-2 Investigators. Sex differences in post-traumatic stress disorder in cardiovascular patients after the Great East Japan Earthquake -A report from the CHART-2 Study- Eur Heart J QCCO. (in press)
  7. Tsuji K, Sakata Y, Nochioka K, Miura M, Yamauchi T, Takeo Onose T, Abe R, Oikawa T, Kasahara S, Sato M, Shiroto T, Takahashi J, Miyata S, Shimokawa S; the CHART-2 Investigators. Characterization of heart failure patients with mid-range left ventricular ejection fraction -A report from the CHART-2 Study- Eur J Heart Fail. DOI: 10.1002/ejhf.807.PDF
  8. Ohtsuki T, Satoh K, Omura J, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Aoki T, Tatebe S, Sugimura K, Takahashi J, Miyata S, Shimokawa H. Prognostic impacts of plasma levels of cyclophilin A in patients with coronary artery disease. Arterioscler Thromb Vasc Biolol. 37:685-693,2017.PDF
  9. Cui Y, Hao K, Takahashi J, Miyata S, Shindo T, Nishimiya K, Kikuchi Y, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H. Age-specific trends in the incidence and in-hospital mortality of acute myocardial infarction over 30 years in Japan - Report from the Miyagi AMI Registry Study- Circ J. 81:520-528,2017.PDF
  10. Yamauchi T, Sakata Y, Miura M, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Shiroto T, Takahashi J, Miyata S, Shimokawa H; the CHART-2 investigators. Prognostic impact of atrial fibrillation and new risk score of its onset in patients at high risk of heart failure -A report from the CHART-2 Study- Circ J. 81:185-194,2017.PDF
  11. Miyata S, Sakata Y, Miura M, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Sato M, Nochioka K, Shiroto T, Takahashi J, Shimokawa H; the CHART-2 investigators. Long-term prognostic impact of the Great East Japan Earthquake in patients with cardiovascular disease -Report from the CHART-2 Study- J Cardiol. DOI:10.1016/j.jjcc.2016.10.018PDF
  12. Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Arai H, Taki Y, Furukawa K, Fukumoto Y, Shimokawa H. Reduced brain-derived neurotrophic factor is associated with cognitive dysfunction in patients with chronic heart failure. Geriatrics and Gerontology International. 17:852-854,2017.PDF
  13. Odaka Y, Takahashi J, Tsuburaya R, Nishimiya K, Hao K, Matsumoto Y, Ito K, Sakata Y, Miyata S, Manita D, Hirowatari Y, Shimokawa H. Plasma concentration of serotonin is a novel biomarker for coronary microvascular dysfunction in patients with suspected angina and unobstructive coronary arteries. Eur Heart J. 38:489-496,2017.PDF
  14. Nochioka K, Biering-Sorensen T, Hansen KW, Sorensen R, Pedersen S, Jorgensen PG, Allan Iversen A, Shimokawa H, Jeger R, Kaiser C, Pfisterer M, Galatius S, on behalf of the BASKET-PROVE Investigators. Long-term outcome in patients with rheumatologic disorders after percutaneous coronary intervention: A BASKET-PROVE Substudy. Eur Heart J. Acute Cardiovasc Care. (in press)PubMed
  15. Satake Y, Satoh K, Nogi M, Omura J, Godo S, Miyata S, Saito H, Tanaka S, Ikumi Y, Yamashita S, Kaiho Y, Tsutsui M, Arai Y, Shimokawa H. Crucial roles of nitric oxide synthases in ss-adrenoceptor-mediated bladder relaxation in mice. Am J Physiol. 312:F33-F42,2017.PDF
2016年
  1. Akata K, Yatera K, Wang KY, Naito K, Ogoshi T, Noguchi S, Kido T, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H. Decreased bronchial eosinophilic inflammation and mucus hypersecretion in asthmatic mice lacking all nitric oxide synthase isoforms. Lung. 194:121-124,2016. PDF
  2. Aoki T, Sugimura K, Nochioka K, Miura M, Tatebe S, Yamamoto S, Yaoita N, Suzuki H, Sato H, Kozu K, Miyata S, Satoh K, Shimokawa H. Effects of balloon pulmonary angioplasty on oxygenation in patients with chronic thromboembolic pulmonary hypertension - Importance of intra-pulmonary shunt - Circ J. 80:2227-2234,2016.PDF
  3. Godo S, Sawada A, Saito H, Ikeda S, Enkhjargal B, Suzuki K, Tanaka S, Shimokawa H. Disruption of physiological balance between nitric oxide and endothelium-dependent hyperpolarization impairs cardiovascular homeostasis in mice. Arterioscler Thromb Vasc Biol. 36:97-107,2016.PDF
  4. Hatanaka K, Ito K, Shindo T, Kagaya Y, Ogata T, Eguchi K, Kurosawa R, Shimokawa H. Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: Roles of mechanotransduction. Am J Physiol. 311:C378-385,2016.PubMed
  5. Ikeda T, Atarashi H, Inoue H, Uchiyama S, Kitazono T, Yamashita T, Shimizu W, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Sakuma I, Saku K, Okumura Y, Nakamura Y, Morimoto H, Matsumoto N, Tsuchida A, Ako J, Sugishita N, Shimizu S, Shimokawa H, the EXPAND Investigators. The EXPAND Study: study design and baseline patient characteristics -Evaluation of effectiveness and safety of Xa inhibitor, rivaroxaban for the prevention of stroke and systemic embolism in a nationwide cohort of Japanese patients diagnosed as non-valvular atrial fibrillation-. Tohoku J Exp Med. 240:259-268,2016.PDF
  6. Jiang L, Konishi H, Nurwidya F, Satoh K, Takahashi F, Ebinuma H, Fujimura K, Takasu K, Jiang M, Shimokawa H, Bujo H, Daida H. Deletion of LR11 attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation with medial thickening in mice. Arterioscler Thromb Vasc Biol. 36:1972-1979,2016.PDF
  7. Komatsu M, Takahashi J, Fukuda K, Takagi Y, Shiroto T, Nakano M, Kondo M, Tsuburaya R, Hao K, Nishimiya K, Nihei T, Matsumoto Y, Ito K, Sakata Y, Miyata S, Shimokawa H. Usefulness of Testing for Coronary Artery Spasm and Programmed Ventricular Stimulation in Survivors of Out-of-Hospital Cardiac Arrest. Circ Arrhythm Electrophysiol. 9:doi:10.1161/CIRCEP.115.003798,2016.PDF
  8. Kudo S, Satoh K, Nogi M, Suzuki K, Sunamura S, Omura J, Kikuchi N, Kurosawa R, Satoh T, Minami T, Ikeda S, Shimokawa H. SmgGDS as a crucial mediator of the inhibitory effects of statins on cardiac hypertrophy and fibrosis. -Novel mechanism of the pleiotropic effects of statins- Hypertension. 67:878-889,2016.PDF
  9. Minami T, Satoh K, Nogi M, Kudo S, Miyata S, Tanaka S, Shimokawa H. Statins up-regulate SmgGDS through ß1-integrin/Akt1 pathway in endothelial cells. Cardiovasc Res. 109:151-161,2016.PDF
  10. Miura M, Sakata Y, Miyata S, Shiba N, Takahashi J, Nochioka K, Takada T, Saga C, Shinozaki T, Sugi M, Nakagawa M, Sekiguchi N, Komaru T, Kato A, Fukuchi M, Nozaki E, Hiramoto T, Inoue K, Goto T, Ohe M, Tamaki K, Ibayashi S, Ishide N, Maruyama Y, Tsuji I, Shimokawa H; SUPPORT Trial Investigators. Influence of left ventricular ejection fraction on the effects of supplemental use of angiotensin receptor blocker olmesartan in hypertensive patients with heart failure. Circ J. 80:2155-2164,2016.PDF
  11. Miura M, Sugimura K, Sakata Y, Miyata S, Tadaki S, Yamauchi T, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Takahashi J, Shimokawa H ; CHART-2 Investigators. Prognostic impact of loop diuretics in patients with chronic heart failure -Effects of addition of renin-angiotensin-aldosterone system inhibitors and β-blockers. Circ J. 80:1396-1403,2016.PDF
  12. Nakano M, Fukuda K, Kondo M, Segawa M, Hirano M, Chiba T, Fukasawa K, Miki K, Morosawa S, Shimokawa H. Prognostic significance of late potentials in outpatients with type 2 Brugada electrocardiogram. Tohoku J Exp Med. 240:191-198,2016.PDF
  13. Nishimiya K, Matsumoto Y, Takahashi J, Uzuka H, Wang H, Tsuburaya R, Hao K, Ohyama K, Odaka Y, Miyata S, Ito K, Shimokawa H. Enhanced adventitial vasa vasorum formation in patients with vasospastic angina -Assessment with optical frequency domain imaging- J Am Coll Cardiol. 67:598-600,2016.PDF
  14. Nishimiya K, Matsumoto Y, Uzuka H, Ohyama K, Hao K, Tsuburaya R, Shiroto T, Takahashi J, Ito K, Shimokawa H. Focal vasa vasorum formation in patients with focal coronary vasospasm -An optical frequency domain imaging study- Circ J. 80:2252-2254,2016.PDF
  15. Nishimiya K, Matsumoto Y, Uzuka H, Ogata T, Hirano M, Shindo T, Hasebe Y, Tsuburaya R, Shiroto T, Takahashi J, Ito K, Shimokawa H. Beneficial effects of novel bioabsorbable polymer coating on enhanced coronary vasoconstricting responses after drug-eluting stent implantation in pigs in vivo. JACC Cardiovasc Interv. 9:281-291,2016.PDF
  16. Ohyama K, Matsumoto Y, Nishimiya K, Hao K, Tsuburaya R, Ota H, Amamizu H, Uzuka H, Takahashi J, Ito K, Shimokawa H. Increased coronary perivascular adipose tissue volume in patients with vasospastic angina. Circ J. 80:1653-1656,2016.PDF
  17. Omura J, Satoh K, Kikuchi N, Satoh T, Kurosawa R, Nogi M, Otsuki T, Kozu K, Numano K, Suzuki K, Sunamura S, Tatebe S, Aoki T, Sugimura K, Miyata S, Hoshikawa Y, Okada Y, Shimokawa H. Protective roles of endothelial AMP-activated protein kinase against hypoxia-induced pulmonary hypertension in mice. Circ Res. 119:197-209,2016.PDF
  18. Saito S, Ishii T, Kamogawa Y, Watanabe R, Shirai T, Fujita Y, Shirota Y, Fujii H, Ito K, Shimokawa H, Yamaguchi T, Kawaguchi Y, Harigae H. Extracorporeal shock wave therapy for digital ulcers of systemic sclerosis: A phase 2 pilot study. Tohoku J Exp Med. 238:39-47,2016. PubMed
  19. Satake H, Sugimura K, Fukumoto Y, Fukuda K, Nakano M, Kondo M, Fukui S, Ogawa H, Shinozaki T, Shimokawa H. Effects of respiratory therapy on the prognosis of chronic heart failure patients complicated with sleep-disordered breathing -A pilot efficacy trial- Circ J. 80:130-138,2016.PDF
  20. Sato H, Ota H, Sugimura K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Satoh K, Takase K, Shimokawa H. Balloon pulmonary angioplasty improves biventricular functions and pulmonary flow in chronic thromboembolic pulmonary hypertension. Circ J. 80:1470-1477,2016.PDF
  21. Segawa M, Fukuda K, Nakano M, Kondo M, Satake H, Hirano M, Shimokawa H. Time course and factors correlating with ventricular tachyarrhythmias after introduction of steroid therapy in cardiac sarcoidosis. Circulation Arrhyth Electrophsiol. 9(6):e003353,2016.PDF
  22. Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Eguchi K, Kagaya Y, Hanawa K, Aizawa K, Shiroto T, Kasukabe S, Miyata S, Taki H, Hasegawa H, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates left ventricular dysfunction in a mouse model of acute myocardial infarction. Arterioscler Throm Vasc Biol. 36:1220-1229,2016.PDF
  23. Suda A, Namiuchi S, Kawaguchi T, Nihei T, Takii T, Saji K, Sugie T, Kato A, Shimokawa H. A simple and rapid method for identification of lesions at high risk for the no-reflow phenomenon immediately before elective coronary stent implantation. Heart Vessels. 31:1904-1914,2016.PDF
  24. Sugimura K, Shinozaki T, Fukui S, Ogawa H, Shimokawa H. End-tidal CO2 tension is predictive of effective nocturnal oxygen therapy in patients with chronic heart failure and central sleep apnea. Tohoku J Exp Med. 239:39-45,2016.PDF
  25. Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Furukawa K, Arai H, Fukumoto Y, Taki Y, Shimokawa H. Hippocampal blood flow abnormality associated with depressive symptoms and cognitive impairment in patients with chronic heart failure. Circ J. 80:1773-1780,2016.PDF
  26. Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H. Basigin promotes cardiac fibrosis and failure in response to chronic pressure-overload in mice. Arterioscler Thromb Vasc Biol. 36:636-646,2016.PDF
  27. Suzuki H, Sugimura K, Tatebe S, Aoki T, Shimokawa H. Chronic thromboembolic pulmonary hypertension and schizophrenia. Int J Cardiol. 207:363-364,2016.PDF
  28. Takagi H, Hideki Ota H, Sugimura K, Otani K, Tominaga J, Aoki T, Tatebe S, Miura M, Yamamoto S, Sato H, Nobuhiro Yaoita N, Suzuki H, Shimokawa H, Takase K. Dual-energy CT to estimate clinical severity of chronic thromboembolic pulmonary hypertension: Comparison with invasive right heart catheterization. Eur J Radiol. 85:1574-1580,2016.PDF
  29. Tadaki S, Sakata Y, Miura Y, Miyata S, Asakura M, Shimada K, Yamamoto T, Fukumoto Y, Kadokami T, Yasuda S, Miura T, Ando S, Yano M, Kitakaze M, Daida H, Shimokawa H. Prognostic impacts of metabolic syndrome in patients with chronic heart failure -A multicenter prospective cohort study- Circ J. 80:677-688,2016.PDF
  30. Tatebe S, Sugimura K, Aoki T, Miura M, Nochioka K, Miyamichi-Yamamoto S, Yaoita N, Suzuki H, Sato H, Satoh K, Fukumoto Y, Shimokawa H. Multiple beneficial effects of balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. Circ J. 80:980-988,2016.PDF
  31. Tsuburaya R, Takahashi J, Nakamura A, Nozaki E, Sugi M, Yamamoto Y, Hiramoto T, Horiguchi S, Inoue K, Goto T, Kato A, Shinozaki T, Ishida E, Miyata S, Yasuda S, Shimokawa H; the NOVEL Investigators. Beneficial effects of long-acting nifedipine on coronary vasomotion abnormalities after drug-eluting stent implantation. -The NOVEL Study- Eur Heart J. 37:2713-2721,2016.PDF
  32. Tsutsui H, Momomura S, Yamashina A, Ogawa H, Shimokawa H, Kihara Y, Saito Y, Hagiwara N, Ito H, Ako J, Inomata T, Tanaka T, Kawasaki Y, on behalf of the study investigators. Heart rate control with If inhibitor, ivabradine, in Japanese patients with chronic heart failure -A randomized, double-blind, placebo-controlled phase II study- Circ J. 80:668-676,2016.PDF
  33. Yahata K, Kanno H, Ozawa H, Yamaya S, Tateda S, Ito K, Shimokawa H, Itoi E. Low-energy extracorporeal shock wave therapy promotes VEGF expression and angiogenesis and improves locomotor and sensory functions after spinal cord injury. J Neurosurg Spine. 1:1-11,2016.PDF
  34. Yamamoto S, Suzuki H, Sugimura K, Tatebe S, Aoki T, Miura M, Yaoita N, Sato H, Kozu K, Ota H, Takanami K, Takase K, Shimokawa H. Focal reduction in cardiac 123I-metaiodobenzylguanidine uptake in patients with Anderson-Fabry disease. Circ J. 80:2550-2551,2016.PDF
  35. Yamauchi T, Sakata Y, Takada T, Nochioka K, Miura M, Tadaki S, Ushigome R, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Miyata S, Shimokawa H. Prognostic impacts of new-onset atrial fibrillation in patients with chronic heart failure -A report from the CHART-2 Study- Circ J. 80:157-167,2016.PDF
  36. Yaoita N, Satoh K, Satoh T, Sugimura K, Tatebe S, Yamamoto S, Aoki T, Miura M, Kawamura T, Horiuchi H, Fukumoto Y, Shimokawa H. Thrombin-activatable fibrinolysis inhibitor in chronic thromboembolic pulmonary hypertension. Arterioscler Throm Vasc Biol. 36:1293-1301,2016. PDF
  37. Yoshida M, Watanabe R, Ishii T, Machiyama T, Akita K, Fujita Y, Shirota Y, Sugimura K, Fujii H, Shimokawa H, Harigae H. Retrospective analysis of 95 patients with large vessel vasculitis: a single center experience. Int J Rheumatic Dis. 19:87-94,2016.PDF
  38. Zheng Y, Wei D, Zhu X, Chen W, Fukuda K, Shimokawa H. Transmural, interventricular, apicobasal and anteroposterior action potential duration gradients are all essential to the genesis of the concordant and realistic T wave: A whole-heart model study. J Electrocardiol. 2016;49:569-78,2016.PDF

研究業績一覧へ |このページのTOPへ

2015年
  1. Ellawindy A, Satoh K, Sunamura S, Kikuchi N, Suzuki K, Minami T, Ikeda S, Tanaka S, Shimizu T, Enkhjargal B, Miyata S, Taguchi Y, Handoh T, Kobayashi K, Kobayashi K, Nakayama K, Miura M, ShimokawaH. Rho-kinase inhibition during early cardiac development causes arrhythmogenic right ventricular cardiomyopathy in mice. Arterioscler Thromb Vasc Biol. 35:2172-2184,2015.PDF
  2. Hao K, Takahashi J, Ito K, Miyata S, Nihei T, Nishimiya K, Tsuburaya R, Matsumoto Y, Sakata Y, Yasuda S, Shimokawa H; MIYAGI-AMI registry study investigators. Clinical characteristics of patients with acute myocardial infarction who did not undergo primary percutaneous coronary intervention- Report from the MIYAGI-AMI registry study. Circ J. 79:2009-2016, 2015.PDF
  3. Hasebe Y, Yamamoto H, Fukuda K, Nishimiya K, Hanawa K, Shindo T, Kondo M, Nakano M, Wakayama Y, Takayama K, Shimokawa H. Development of a novel shock wave catheter ablation system -The first feasibility study in pigs- PLoS One. 2015;10(1):e0116017.PDF
  4. Jang JH, Chun JN, Godo S, Wu G, Shimokawa H, Jin CZ, Jeon JH, Kim SJ, Jin ZH, Zhang YH. ROS and endothelial nitric oxide synthase(eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes. Basic Res Cardiol. 110:21, 2015.PDF
  5. Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Shimokawa H, the CHART-2 investigators. Prognostic impact of diabetes mellitus in chronic heart failure according to presence of ischemic heart disease. -With special reference to nephropathy- Circ J. 79:1764-1772,2015.PDF
  6. Nishimiya K, Matsumoto Y, Shindo T, Hanawa K, Hasebe Y, Tsuburaya R, Shiroto T, Takahashi J, Ito K, Ishibashi-Ueda H, Yasuda S, Shimokawa H. Association of adventitial vasa vasorum and inflammation with coronary hyperconstriction after drug-eluting stent implantation in pigs in vivo. Circ J. 79:1787-1798,2015.PDF
  7. Nishimiya K, Matsumoto Y, Uzuka H, Oyama K, Tanaka A, Taruya A, Ogata T, Hirano M, Shindo T, Hanawa K, Hasebe Y, Hao K, Tsuburaya R, Takahashi J, Miyata S, Ito K, Akasaka T, Shimokawa H. Accuracy of optical frequency domain imaging for evaluation of coronary adventitial vasa vasorum formation after stent implantation in pigs and humans -A validation study- Circ J. 79:1323-1331,2015.PDF
  8. Nochioka K, Sakata Y, Miyata S, Miura M, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H. Prognostic impact of statin use in patients with heart failure with preserved ejection fraction -A report from the CHART-2 Study- Circ J. 79:574-582,2015.PDF
  9. Noda K, Godo S, Saito H, Tsutsui M, Shimokawa H. Opposing roles of nitric oxide and Rho-kinase in lipid metabolism in mice.Tohoku J Exp Med. 235:171-183,2015.PDF
  10. Onose T, Nochioka K, Sakata Y, Miura M, Tadaki S, Ushigome R, Yamauchi T, Sato K, Tsuji K, Abe R, Miyata S, Takahashi J, Shimokawa H. Predictors and prognostic impact of post-traumatic stress disorder after the Great East Japan Earthquake in patients with cardiovascular disease -- Report from the CHART-2 Study -- Circ J. 79:664-667,2015.PDF
  11. Ota H, Sugimura K, Miura M, Shimokawa H. 4D flow MRI visualizes drastic change of vortex flow in the main pulmonary artery after percutaneous transluminal balloon angioplasty in a patient with chronic thromboembolic pulmonary hypertension. Eur Heart J. 36:1630,2015.PDF
  12. Sakata Y, Shiba N, Takahashi J, Miyata S, Nochioka K, Miura M, Takada T, Saga C, Shinozaki T, Sugi M, Nakagawa M, Sekiguchi N, Komaru T, Kato A, Fukuchi M, Nozaki E, Hiramoto T, Inoue K, Goto T, Ohe M, Tamaki K, Ibayashi S, Ishide N, Maruyama Y, Tsuji I, Shimokawa H, on behalf of the SUPPORT Trial Investigators. Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure. -The supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) Trial- Eur Heart J. 36:915-923,2015. PDF
  13. Satake H, Fukuda K, Sakata Y, Miyata S, Nakano M, Kondo M, Hasebe Y, Segawa M, Shimokawa H, the CHART-2 Investigators. Current status of primary prevention of sudden cardiac death with implantable cardioverter defibrillator in patients with chronic heart failure. -A report from the CHART-2 Study- Circ J. 79:381-390,2015.PDF
  14. Sato K, Sakata Y, Miura M, Tadaki S, Ushigome R, Yamauchi T, Onode T, Tsuji K, Abe R, Nochioka K, Takahashi J, Miyata S, Shimokawa H, the CHART-2 investigators. Comprehensive risk stratefification of Japanese patients with aortic stenosis. -A proposal of a new risk score from the CHART-2 Study- Circ J. 79:1631-1638,2015.PDF
  15. Suzuki H, Sumiyoshi A, Matsumoto Y, Duffy B, Yoshikawa T, Lythgoe M, Yanai K, Taki Y, Kawashima R, Shimokawa H. Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats. NeuroImage. 105:84-92,2015.PDF
  16. Takahashi J, Nihei T, Takagi Y, Miyata S, Odaka Y, Tsunoda R, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Momomura S, Yasuda S, Ogawa H, Shimokawa H, on behalf of the Japanese Coronary Spasm Association. Prognostic impact of chronic nitrate therapy in patients with vasospastic angina -Multicenter registry study of the Japanese Coronary Spasm Association- Eur Heart J. 36:228-237,2015.PDF
  17. Takegami M, Miyamoto Y, Yasuda S, Nakai M, Nishimura K, Ogawa H, Hirata K, Toh R, Morino Y, Nakamura M, Takeishi Y, Shimokawa H, Naito H. Comparison of cardiovascular mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes - a large-scale data analysis of death certificates. Circ J. 2015;79:1000-8, 1015.PDF
  18. Ushigome R, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H, the CHART-2 Investigators. Temporal trends in clinical characteristics, management and prognosis of patients with symptomatic heart failure in Japan -A report from the CHART Studies- Circ J. 79:2396-2407,2015.PDF
  19. Ushigome R, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Shimokawa H; the CHART-2 Investigators, Improved long-term prognosis of patients with dilated cardiomyopathy with implementation of evidenced-based medications. -A report from the CHART Studies- Circ J. 79:1332-1341,2015.PDF
  20. Yamauchi T, Sakata Y, Takada T, Nochioka K, Miura M, Tadaki S, Ushigome R, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Miyata S, Shimokawa H; CHART-2 investigators. Prognostic impact of anemia in patients with chronic heart failure- With special reference to clinical background: Report from the CHART-2 Study. Circ J. 79:1984-1993, 2015.PDF
  21. Zheng Y, Wei D, Zhu X, Chen W, Fukuda K, Shimokawa H. Ventricular fibrillation mechanisms and cardiac restitutions: An investigation by simulation study on whole-heart model. Comput Biol Med. 63:261-268,2015.PDF

研究業績一覧へ |このページのTOPへ

2014年
  1. Abe Y, Ito K, Hao K, Shindo T, Ogata T, Kagaya Y, Kurosawa R, Nishimiya K, Satoh K, Miyata S, Kawakami K, Shimokawa H. Extracorporeal low-energy shock-wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction. Circ J. 78:2915-2925,2014.PDF
  2. Al-Mamun ME, Satoh K, Tanaka S, Shimizu T, Nergui S, Miyata S, Fukumoto Y, Shimokawa H. Combination therapy with fasudil and sildenafil ameliorates monocrotaline-induced pulmonary hypertension and survival in rats. Circ J. 78:967-976,2014.PDF
  3. Dai Z, Fukumoto Y, Tatebe S, Sugimura K, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H. OCT imaging for the management of pulmonary hypertension. JACC-Cardiovasc Imaging. 7:843-845,2014.PDF
  4. Dai Z, Sugimura K, Fukumoto Y, Tatebe S, Miura Y, Nochioka K, Aoki T, Miyamichi-Yamamoto S, Yaoita N, Satoh K, Shimokawa H. Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension. Circ J. 78:2771-2773,2014.PDF
  5. Enkhjargal B, Godo S, Sawada A, Suvd N, Saito H, Noda K, Satoh K, Shimokawa H. Endothelial AMPK regulates blood pressure and coronary flow responses through hyperpolarization mechanism in mice. Arterioscler Thromb Vasc Biol. 34:1505-1513,2014.PDF
  6. Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, Tsuburaya R Hasegawa H, Yasuda S, Kanai H, Shimokawa H. Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. PLoS One. 2014;9(8):e104863.PDF
  7. Hao K, Takahashi J, Aoki T, Miyata S, Ito K, Sakata Y, Shimokawa H. Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake Disaster. Intn'l J Cardiol. 177:569-572,2014.PDF
  8. Hao K, Takahashi J, Ito K, Miyata S, Sakata Y, Nihei T, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Yasuda S, Shimokawa H. Emergency care of acute myocardial infarction and the Great East Japan Earthquake Disaster -Report From the Miyagi AMI Registry Study- Circ J. 78:634-643,2014.PDF
  9. Ikeda S, Satoh K, Kikuchi N, Miyata S, Suzuki K, Omura J, Shimizu T, Kobayashi K, Kobayashi K, Fukumoto Y, Sakata Y, Shimokawa H. Crucial role of Rho-kinase in pressure-overload-induced right ventricular hypertrophy and dysfunction in mice. Arterioscler Thromb Vasc Biol. 34:1260-1271,2014.PDF
  10. Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H. Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure -A report from the CHART-2 Study- Circ J. 78:2890-2898,2014.PDF
  11. Miura M, Sakata Y, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Miyata S, Shiba N, Shimokawa H. Prevalence, predictors and prognosis of patients with heart failure requiring nursing care --Report from the CHART-2 Study- Circ J. 78:2276-2283,2014.PDF
  12. Nergui S, Fukumoto Y, Do.e Z, Nakajima S, Shimizu T, Ikeda S, Elias-Al-Mamun M, Shimokawa H. Role of eNOS and collagen metabolism in right ventricular remodeling due to pulmonary hypertension. Circ J. 78:1465-1474,2014.PDF
  13. Nihei T, Takahashi J, Tsuburaya R, Ito Y, Shiroto T, Hao K, Takagi Y, Matsumoto Y, Nakayama M, Miyata S, Sakata Y, Ito K, Shimokawa H. Circadian variation of rho-kinase activity in circulating leukocytes of patients with vasospastic angina. Circ J. 78:1183-1190,2014.PDF
  14. Nishimiya K, Matsumoto Y, Takahashi J, Uzuka H, Odaka Y, Nihei T, Hao K, Tsuburaya R, Ito K, Shimokawa H. In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging -Validation Study- Circ J. 78:2516-2518,2014.PDF
  15. Noda K, Nakajima S, Godo S, Saito H, Ikeda S, Shimizu T, Enkhjargal B, Fukumoto Y, Tsukita S, Yamada T, Katagiri H, Shimokawa H. Rho-kinase inhibition ameliorates metabolic disorders through activation of AMPK pathway in mice. PLoS One. 2014;9(11):e110446.PDF
  16. Noguchi S, Yatera K, Wang KY, Oda K, Akata K, Yamasaki K, Kawanami T, Ishimoto H, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H. Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice. Respir Res. 15:92.doi:10.1186/s12931-014-0092-3.PDF
  17. Sakata Y, Miyata S, Nochioka K, Miura M, Takada T, Tadaki S, Takahashi J, Shimokawa H. Gender differences in clinical characteristics, treatment and long-term outcome in patients with stage C/D heart failure in Japan -A report from the CHART-2 Study- Circ J. 78:428-435,2014.PDF
  18. Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H. Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Circ Res. 115:738-750,2014.PDF
  19. Shiroto T, Romero N, Sugiyama T, Sartoretto JL, Kalwa H, Yan Z, Shimokawa H, Michel T. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One 2014;9(2):e87871.PDF
  20. Suzuki H, Matsumoto Y, Kaneta T, Sugimura K, Takahashi J, Fukumoto Y, Takahashi S, Shimokawa H. Evidence for brain activation in patients with takotsubo cardiomyopathy. Circ J. 78:256-258,2014.PDF
  21. Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Shimokawa H, on behalf of the CHART-2 Investigators. Impact of elevated heart rate on clinical outcomes in patients with heart failure with reduced and preserved ejection fraction. -A report from the CHART-2 Study- Eur J Heart Fail. 16:309-316,2014.PDF
  22. Tatebe S, Fukumoto Y, Oikawa-Wakayama M, Sugimura K, Satoh K, Miura Y, Aoki T, Nochioka K, Miura M, Yamamoto S, Tashiro M, Kagaya Y, Shimokawa H. Enhanced [18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension: A preliminary observational study. Eur Heart J -Cardiovasc Imaging. 15:666-672,2014.PDF
  23. Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M. Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. J Mol Cell Cardiol. 77:29-41,2014.PDF
  24. Yamaki S, Ando M, Fukumoto Y, Higuchi Y, Kaneko K, Maeda K, Shimokawa H. Histopathological examination by lung biopsy for the evaluation of operability and postoperative prognosis in patients with chronic thromboembolic pulmonary hypertension. Circ J. 78:476-482,2014.PDF
  25. Yamaya S, Ozawa H, Kanno H, Kishimoto KN, Sekiguchi A, Tateda S, Yahata K, Ito K, Shimokawa H, Itoi E. Low-energy extracorporeal shock wave therapy promotes VEGF expression and neuroprotection and improves locomotor recovery after spinal cord injury. J Neurosurg. 121:1514-1525,2014.PDF
  26. Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H. Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (CTEPH). Arterioscler Thromb Vasc Biol. 34:2486-2494,2014.PDF

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2013年
  1. Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T, Sukegawa H, Ogata K, Shimokawa H. Effect of the Great East Japan Earthquake Disaster on cardiovascular diseases -A report from the 10 hospitals in the Disaster area- Circ J. 77:490-493,2013.PDF
  2. Do.e Z, Fukumoto Y, Sugimura K, Miura Y, Tatebe S, Yamamoto S, Aoki T, Nochioka K, Nergui S, Yaoita N, Satoh K, Kondo M, Nakano M, Wakayama Y, Fukuda K, Nihei T, Kikuchi Y, Takahashi J, Shimokawa H. Rho-kinase activation in patients with heart failure. Circ J. 77:2542-2550,2013.PDF
  3. Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T. The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. Am J Respir Cell Mol Biol. 49:324-333,2013.PDF
  4. Fukumoto Y, Yamada N, Matsubara H, Mizoguchi M, Uchino K, Yao A, Kihara Y, Kawano M, Watanabe H, Takeda Y, Adachi T, Osanai S, Tanabe N, Inoue T, Kubo A, Ota Y, Fukuda K, Nakano T, Shimokawa H. Double-blind, placebo-controlled clinical trial with a Rho-kinase inhibitor in pulmonary arterial hypertension -A pilot efficacy trial- Circ J. 77:2619-2625,2013.PDF
  5. Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu F, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Park JE, Tada-Oikawa S, Kitajima H, Matsubara T, Sunagawa K, Shimokawa H, Kimura A, Lee JY, Murohara T, Inoue I, Yokota M. Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis. Circulation: Cardiovascular Genetics. 6:569-578,2013.PDF
  6. Ito D, Ito O, Mori N, Cao P, Suda C, Yoshikazu Muroya Y, Hao K, Shimokawa H, Kohzuki M. Exercise training upregulates nitric oxide synthases in the kidney of rats with chronic heart failure. Clin Exp Pharmacol Physiol. 40:617-625,2013.PDF
  7. Kawana A, Takahashi J, Takagi Y, Yasuda S, Sakata Y, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Gender differences in clinical characteristics and outcomes of patients with vasospastic angina -A report from the Japanese Coronary Spasm Association- Circ J. 77:1267-1274,2013.PDF
  8. Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H, on behalf of the CHART-2 Investigators. Usefulness of combined risk stratification with Heart rate and systolic blood pressure in the management of chronic heart failure -A report from the CHART-2 Study- Circ J. 77:2954-2962,2013.PDF
  9. Miura M, Sakata Y, Nochioka K, Takahashi J, Takada T, Miyata S, Hiramoto T, Inoue K, Tamaki K, Shiba N, Shimokawa H. Prognostic impact of blood urea nitrogen changes during hospitalization in patients with acute heart failure syndrome. Circ J. 77:1221-1228,2013.PDF
  10. Miura Y, Fukumoto Y, Miura T, Shimada K, Asakura M, Kadokami T, Ando SI, Miyata S, Sakata Y, Daida H, Matsuzaki M, Yasuda S, Kitakaze M, Shimokawa H. Impact of physical activity on cardiovascular events in patients with chronic heart failure -- A multicenter prospective cohort study -- Circ J. 77:2963-2972,2013.PDF
  11. Nakayama M, Shimokawa H.Evaluation of an electrocardiogram on QR code. Stud Health Technol Inform. 192:1020,2013.PDF
  12. Nakayama M, Takeda M, Asaumi Y, Shimokawa H. Identification and visualization of stimulus-specific transcriptional activity in cardiac hypertrophy in mice. Int J Cardiovasc Imaging. 30:211-219,2013.PDF
  13. Nochioka K, Sakata Y, Takahashi J, Miyata S, Miura M, Takada T, Fukumoto Y, Shiba N, Shimokawa H. Prognostic impact of nutritional status in asymptomatic patients with cardiac diseases: a report from the CHART-2 Study. Circ J. 77:2318-2326,2013.PDF
  14. Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H. Nitric Oxide Mediates Selective Degeneration of Hypothalamic Orexin Neurons through Dysfunction of Protein Disulfide Isomerase. J Neurosci. 33:12557-12568,2013.PDF
  15. Sakata Y, Nochioka K, Miura M, Takada T, Tadaki S, Miyata S, Shiba N, Shimokawa H, for the SUPPORT Trial Investigators. Supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial-Rationale and design. J Cardiol. 62:31-36,2013.PDF
  16. Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S, Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H. Plasma cyclophilin A is a novel biomarker for coronary artery disease. Circ J. 77:447-455,2013.PDF
  17. Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Ikeda S, Shimokawa H. Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice. Arterioscler Thromb Vasc Biol. 33:2780-2791,2013.PDF
  18. Sugimura K, Fukumoto Y, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Satoh K, Yamamoto S, Yaoita N, Shimokawa H. Three-dimensional-optical coherence tomography imaging of chronic thromboembolic pulmonary hypertension. Eur Heart J. 34:2121,2013.PDF
  19. Suzuki H, Sumiyoshi A, Kawashima R, Shimokawa H. Diffrenet brain activation under left and right ventricular stimulation: An fMRI study in anesthetized rats. PLoS One 2013;8(2):e56990.PDF
  20. Suzuki H, Sumiyoshi A, Taki Y, Matsumoto Y, Fukumoto Y, Kawashima R, Shimokawa H. Voxel-based morphometry and histological analysis for evaluating hippocampal damage in a rat model of cardiopulmonary resuscitation. Neuroimage. 77:215-221,2013.PDF
  21. Takagi Y, Takahashi J, Yasuda S, Miyata S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H, on Behalf of the Japanese Coronary Spasm Association. Prognostic stratification of patients with vasospastic angina - A comprehensive clinical risk score developed by the Japanese Coronary Spasm Association - J Am Coll Cardiol. 62:1144-1153,2013.PDF
  22. Takagi Y, Yasuda S, Takahashi J, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact -Multicenter registry study of the Japanese Coronary Spasm Association- Eur Heart J. 34:258-267,2013.PDF
  23. Takahashi K, Matsumoto Y, Do.e Z, Kanazawa M, Satoh K, Shimizu T, Sato A, Fukumoto Y, Shimokawa H. Combination therapy with atorvastatin and amlodipine suppresses angiotensin II-induced aortic aneurysm formation. PLoS One 2013;8(8):e72558.PDF
  24. Tanaka S, Fukumoto Y, Nochioka K, Minami T, Kudo S, Shiba N, Takai Y, Williams CL, Liao JK, Shimokawa H. Statins Exert the Pleiotropic Effects Through Small GTP-Binding Protein Dissociation Stimulator Upregulation With a Resultant Rac1 Degradation. Arterioscler Thromb Vasc Biol. 33:1591-1600,2013.PDF
  25. Tatebe S, Fukumoto Y, Sugimura K, Miura Y, Nochioka K, Aoki T, Miura M, Yamamoto S, Yaoita N, Satoh K, Shimokawa H. Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension. Circ J. 77:1081-1083,2013.PDF

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2012年
  1. Aizawa K, Yasuda S, Takahashi J, Takii T, Kikuchi Y, Tsuburaya R, Ito Y, Ito K, Nakayama M, Takeda M, Shimokawa H. Involvement of Rho-kinase activation in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in patients with coronary artery disease. Circ J. 76:2552-2560,2012.PDF
  2. Aoki T, Fukumoto Y, Yasuda S, Sakata Y, Ito K, Takahashi J, Miyata S, Tsuji I, Shimokawa H. The Great East Japan Earthquake Disaster and cardiovascular diseases. Eur Heart J. 33:2796-2803,2012.PDF
  3. Benkhoff S, Loot AE, Pierson I, Sturza A, Kohlstedt K, Fleming I, Shimokawa H, Grisk O, Brandes RP, Schroder K. Leptin potentiates endothelium-dependent relaxation by inducing endothelial expression of neuronal NO synthase. Arteriscler, Thromb, Vasc Biol. 32:1605-1612,2012.PDF
  4. Dai Z, Aoki T, Fukumoto Y, Shimokawa H. Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure. J Cardiol. 60:416-421,2012.PDF
  5. Hao K, Yasuda S, Takii T, Ito Y, Takahashi J, Ito K, Nakayama M, Shiba N, Fukumoto Y, Shimokawa H. Urbanization, life-style changes and incidence and in-hospital mortality from acute myocardial infarction in Japan -Report from the MIYAGI-AMI Registry- Circ J. 76:1136-1144,2012.PDF
  6. Hayashi D, Kawakami K, Ito K, Ishii K, Tanno H, Imai Y, Kanno E, Maruyama R, Shimokawa H, Tachi M. Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase. Wound Repair Regen. 20:887-895,2012.PDF
  7. Kondo M, Fukuda K, Wakayama Y, Nakano M, Hasebe Y, Shimokawa H. Usefulness of the non-contact mapping system to elucidate the conduction property for the treatment of common atrial flutter. PACE. 35:1464-1471,2012.PDF
  8. Miura M, Shiba N, Nochioka K, Takada T, Takahashi J, Kohno H, Shimokawa H, on behalf of the CHART-2 Investigators. Urinary albumin excretion in heart failure with preserved ejection fraction: an interim analysis of the CHART 2 study. Eur J Heart Fail. 14:367-376,2012.PDF
  9. Nakajima S, Ohashi J, Sawada A, Noda K, Fukumoto Y, Shimokawa H. Essential role of bone marrow for microvascular endothelial and metabolic functions in mice. Circ Res. 111:87-96,2012.PDF
  10. Nakano M, Kondo M, Wakayama Y, Kawana A, Hasebe Y, Shafee MA, Fukuda K, Shimokawa H. Increased Incidence of tachyarrhythmias and heart failure hospitalization in patients implanted with cardiac devices after the Great East Japan Earthquake Disaster. Circ J. 76:1283-1285,2012.PDF
  11. Nihei T, Takahashi J, Kikuchi Y, Takagi Y, Hao K, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H. Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake. Circ J. 76:2892-2894,2012.PDF
  12. Nochioka K, Tanaka S, Miura M, Zhulanqiqige DE, Fukumoto Y, Shiba N, Shimokawa H. Ezetimibe improves endothelial function and inhibits Rho-kinase activity associated with inhibition of cholesterol absorption in humans. Circ J. 76:2023-2030,2012.PDF
  13. Noda K, Hosoya M, Nakajima S, Ohashi J, Fukumoto Y, Shimokawa H. Anti-atherogenic effects of the combination therapy with olmesartan and azelnidipine in diabetic apolipoprotein e-deficient mice. Tohoku J Exp Med. 228:305-315,2012.PDF
  14. Ohashi J, Sawada A, Nakajima S, Noda K, Takaki A, Shimokawa H. Mechanisms for enhanced endothelium-derived hyperpolarizing factor-mediatedresponses in microvessels in mice. Circ J. 76:1768-1779,2012.PDF
  15. Satoh S, Kawasaki K, Ikegaki I, Asano T, Shimokawa H. Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy. Biochem Biophys Res Commun. 424:338-340,2012.PDF
  16. Serizawa F, Ito K, Kawamura K, Tsuchida K, Hamada Y, Zukeran T, Shimizu T, Akamatsu D, Hashimoto M, Goto H, Watanabe T, Sato A, Shimokawa H, Satomi S. Extracorporeal shock wave therapy ameliorates walking ability of patients with peripheral artery disease and intermittent claudication. Circ J. 76:1486-1493,2012.PDF
  17. Shafee MA, Fukuda K, Wakayama Y, Nakano M, Kondo M, Hasebe Y, Kawana A, Shimokawa H. Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. J Cardiol. 60:448-453,2012.PDF
  18. Sumiyoshi A, Suzuki H, Shimokawa H, Kawashima R. Neurovascular uncoupling under mild hypoxic hypoxia: an EEG-fMRI study in rats. J Cereb Blood Flow Metab. 32:1853-1858,2012.PDF
  19. Sumiyoshi A, Suzuki H, Ogawa T, Riera JJ, Shimokawa H, Kawashima R. Coupling between gamma oscillation and fMRI signal in the rat somatosensory cortex: Its dependence on systemic physiological parameters. NeuroImage. 60:738-746,2012.PDF
  20. Sugimura K, Fukumoto Y, Satoh K, Nochioka K, Miura Y, Aoki T, Tatebe S, Miyamichi-Yamamoto S, Shimokawa H. Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension. Circ J. 76:485-488,2012.PDF
  21. Suzuki H, Hirose M, Watanabe S, Fukuda K, Fukudo S, Shimokawa H. Brain responses to cardiac electrical stimulation: a new EEG method for evaluating cardiac sensation. Tohoku J Exp Med. 226:3-10,2012.PDF
  22. Tatebe S, Fukumoto Y, Sugimura K, Miyamichi-Yamamoto S, Aoki T, Miura Y, Nochioka K, Satoh K, Shimokawa H. Clinical significance of reactive post-capillary pulmonary hypertension in patients with left heart disease. Circ J. 76:1235-1244,2012.PDF
  23. Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H. Long-term treatment with nifedipine suppresses coronary hyperconstricting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: possible involvement of Rho-kinase pathway. Eur Heart J. 33:791-799,2012.PDF

研究業績一覧へ |このページのTOPへ

2011年
  1. Aoki T, Fukumoto Y, Sugimura K, Oikawa M, Satoh K, Nakano M, Nakayama M, Shimokawa H. Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure -Comparison between preserved and reduced ejection fraction heart failure- Circ J. 75:2605-2613,2011.PDF
  2. Fukuda K, Watanabe J, Yagi T, Wakayama Y, Nakano M, Kondoh M, Kumagai K, Miura M, Shirato K, Shimokawa H. A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability. Tohoku J Exp Med. 225:35-42,2011.PDF
  3. Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M. Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: Involvement of bone marrow-derived cells. Nitric Oxide. 25:350-359,2011.PDF
  4. Gao JY, Yasuda S, Tsuburaya R, Ito Y, Shiroto T, Hao K, Aizawa K, Kikuchi Y, Ito K, Shimokawa H. Long-term treatment with eicosapentaenoic acid ameliorates myocardial ischemia-reperfusion injury in pigs in vivo -Involvement of Rho-kinase pathway inhibition- Circ J. 75:1843-1851,2011.PDF
  5. Kikuchi Y, Yasuda S, Aizawa K, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H. Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment. J Am Coll Cardiol. 58:1231-1237,2011.PDF
  6. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metabolism. 13:294-307,2011.PDF
  7. Miura M, Hirose M, Endoh H, Wakayama Y, Sugai Y, Nakano M, Fukuda K, Shindoh C, Shirato K, Shimokawa H. Acceleration of Ca2+ waves in monocrotaline-induced right ventricular hypertrophy in the rat. Circ J. 75:1343-1349,2011.PDF
  8. Miyamichi-Yamamoto S, Fukumoto Y, Sugimura K, Ishii T, Satoh K, Miura U, Taktebe S, Nochioka K, Aoki T, Do.e Zhulanqiqige, Shimokawa H. Intensive immunosuppressive therapy improves pulmonary hemodynamics and long-term prognosis in patients with pulmonary arterial hypertension associated with connective tissue disease. Circ J. 75:2668-2674,2011.PDF
  9. Nakayama M, Osaki S, Shimokawa H. Validation of the mortality risk stratification models for cardiovascular disease. Am J Cardiol. 108:391-396,2011.PDF
  10. Pineda AA, Minohara M, Kawamura N, Matsushita T, Yamasaki R, Sun X, Piao H, Shimokawa H, Kira J. Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis. J Neurol Sci. 306:115-120,2011.PDF
  11. Rabieyousefi M, Soroosh P, Satoh K, Date1 F, Ishii N, Yamashita M, Oka M, McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M. Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension. BMC Immunology. 12:67-79,2011.PDF
  12. Serizawa F, Ito K, Matsubara M, Sato A, Shimokawa H, Satomi S. Extracorporeal Shock Wave Therapy Induces Therapeutic Lymphangiogenesis in a Rat Model of Secondary Lymphoedema. Eur J Vasc Endovasc Surg. 42:254-260,2011.PDF
  13. Shiba N, Nochioka K, Miura M, Kouno H, Shimokawa H. Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan--first report from the CHART-2 study. Circ J. 75:823-833,2011.PDF
  14. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H. Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest. -Multicenter registry study of the Japanese Coronary Spasm Association- Circulation Arrhythmia & Electrophysiology. 4:295-302,2011.PDF
  15. Tsuburaya R, Yasuda S, Ito Y, Shiroto T, Gao JY, Ito K, Shimokawa H. Eicosapentaenoic acid reduces ischemic ventricular fibrillation via altering monophasic action potential in pigs. J Mol Cell Cardiol. 51:329-336,2011.PDF
  16. Wang W, Kagaya Y, Asaumi Y, Fukui S, Takeda M, Shimokawa H. Protective effects of recombinant human erythropoietin against pressure overload-induced left ventricular remodeling and premature death in mice. Tohoku J Exp Med. 225:131-143,2011.PDF

研究業績一覧へ |このページのTOPへ

2010年
  1. Fujita H, Fukumoto Y, Saji K, Sugimura K, Demachi J, Nawata J, Shimokawa H. Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. Heart & Vessels. 25:144-149,2010.PDF
  2. Hosoya M, Ohashi J, Sawada A, Takaki A, Shimokawa H. Combination therapy with olmesartan and azelnidipine improves EDHF-mediated responses in diabetic Apolipoprotein E-deficient mice. Circ J. 74:798-806,2010.PDF
  3. Ito Y, Ito K, Shiroto T, Tsuburaya R, Yi GJ, Takeda M, Fukumoto Y, Yasuda S, Shimokawa H. Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo. Coronary Art Dis. 21:304-311,2010.PubMed
  4. Kikuchi Y, Ito K, Ito Y, Shiroto T, Tsuburaya R, Aizawa K, Hao K, Fukumoto Y, Takahashi J, Takeda M, Nakayama M, Yasuda S, Kuriyama S, Tsuji I, Shimokawa H. Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris. Circ J. 74:589-591,2010.PDF
  5. Matsumoto Y, Adams V, Jacob S, Mangner N, Schuler G, Linke A. Regular exercise training prevents aortic valve disease in low-density lipoprotein-receptor-deficient mice. Circulation. 121:759-767,2010.PDF
  6. Miura Y, Fukumoto Y, Shiba N, Miura T, Shimada K, Iwama Y, Takagi A, Matsusaka H, Tsutsumi T, Yamada A, Kinugawa S, Asakura M, Okamatsu S, Tsutsui H, Daida H, Matsuzaki M, Tomoike H, Shimokawa H. Prevalence and clinical implication of metabolic syndrome in chronic heart failure. Circ J. 74:2612-2621,2010.PDF
  7. Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S, Watanabe S, Masahito Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M. Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo. J Pharmacol Sci. 114:379-389,2010.PDF
  8. Nakano M, Fukumoto Y, Satoh K, Ito Y, Kagaya Y, Ishii N, Sigamura K, Shimokawa H. OX40 ligand plays an important role in the development of atherosclerosis through vasa vasorum neovascularization. Cardiovasc Res. 88:539-546,2010.PDF
  9. Nishigaki K, Inoue Y, Yamanouchi Y, Fukumoto Y, Yasuda S, Sueda S, Urata H, Shimokawa H, Minatoguchi S. Prognostic effects of calcium channel blockers in patients with vasospastic angina--a meta-analysis. Circ J. 74:1943-1950,2010.PDF
  10. Nochioka K, Shiba N, Kohno H, Miura M, Shimokawa H. Both high and low body mass indexes are prognostic risks in Japanese patients with chronic heart failure: implications from the CHART study. J Cardiac Failure. 16:880-887,2010.PDF
  11. Shibata K, Yatera Y, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Yamazaki F, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases. Circ J. 74:2681-2692,2010.PDF
  12. Sugimura K, Fukumoto Y, Nawata J, Wang H, Onoue N, Tada T, Shirato K, Shimokawa H. Hypertension promotes phosphorylation of focal adhesion kinase and proline-rich tyrosine kinase 2 in rats: implication for the pathogenesis of hypertensive vascular disease. Tohoku J Exp Med. 222:201-210,2010.PDF
  13. Takii T, Yasuda S, Takahashi J, Ito K, Shiba N, Shirato K, Shimokawa H. Trends in acute myocardial infarction incidence and mortality over 30 years in Japan: report from the MIYAGI-AMI Registry Study. Circ J. 74:93-100,2010. (2010年度優秀論文賞受賞)PDF
  14. Tatebe S, Fukumoto Y, Sugimura K, Nakano M, Miyamichi S, Satoh K, Oikawa M, Shimokawa H. Optical coherence tomography as a novel diagnostic tool for distal type chronic thromboembolic pulmonary hypertension. Circ J. 74:1742-1744,2010.PDF
  15. Yada T, Shimokawa H, Hiramatsu O, Satoh M, Kashihara N, Takaki A, Goto M, Ogasawara Y, Kajiya F. Erythropoietin enhances hydrogen peroxide-mediated dilatation of canine coronary collateral arterioles during myocardial ischemia in dogs in vivo. Am J Physiol. 299:H1928-H1935,2010.PDF
  16. Yasuda S, Shimokawa H. Potential usefulness of fish oil in the primary prevention of acute coronary syndrome. Eur Heart J. 31:15-16,2010. (Editorial)PDF
  17. Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet. Cardiovasc Res. 87:675-682,2010.PDF

研究業績一覧へ |このページのTOPへ

2009年
  1. Arakawa K, Yasuda S, Hao H, Kataoka Y, Morii I, Kasahara Y, Kawamura A, Ishibashi-Ueda H, Miyazaki S. Significant association between neutrophil aggregation in aspirated thrombus and myocardial damage in patients with ST-segment elevation acute myocardial infarction. Circ J. 73:139-144,2009.PDF
  2. Arita R, Hata Y, Nakao S, Kita T, Miura M, Kawahara S, Zandi S, Almulki L, Tayyari F, Shimokawa H, Hafezi-Moghadam A, Ishibashi T. Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. Diabetes. 58:215-226,2009.PDF
  3. Doe Zhulangigige, Fukumoto Y, Takaki A, Tawara S, Ohashi J, Nakano M, Tada T, Saji K, Sugimura K, Fujita H, Hoshikawa Y, Nawata J, Kondo T, Shimokawa H. Evidence for Rho-kinase activation in patients with pulmonary arterial hypertension. Circ J. 73:1731-1739,2009.(2009年度最優秀論文賞受賞)PDF
  4. Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Shinozaki T, Kagaya Y, Watanabe J, Shimokawa H. Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats. Hypertens Res. 32:472-480,2009.PDF
  5. Kataoka Y, Yasuda S, Morii I, Kawamura A, Miyazaki S. Improved long-term prognosis of elderly women in the era of sirolimus-eluting stents. Circ J. 73:1219-1227,2009.PDF
  6. Lenk K, Schur R, Linke A, Erbs S, Matsumoto Y, Adams V, Schuler G. Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model. Eur J Heart Fail. 11:342-348,2009.PDF
  7. Masumiya H, Asaumi Y, Nishi M, Minamisawa S, Adachi-Akahane S, Yoshida M, Kangawa K, Ito K, Kagaya Y, Yanagisawa T, Yamazaki T, Ma J, Takeshima H. Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes. Channels (Austin). 3:6-11,2009.PDF
  8. Matsumoto Y, Adams V, Walther C, Kleinecke C, Brugger P, Linke A, Walther T, Mohr FW, Schuler G. Reduced number and function of endothelial progenitor cells in patients with aortic valve stenosis: a novel concept for valvular endothelial cell repair. Eur Heart J. 30:346-355,2009.PDF
  9. Mori S, Yasuda S, Kataoka Y, Morii I, Kawamura A, Miyazaki S. Significant association of coronary artery calcification in stent delivery route with restenosis after sirolimus-eluting stent implantation. Circ J. 73:1856-1863,2009.PDF
  10. Rashid M, Tawara S, Fukumoto Y, Seto M, Yano K, Shimokawa H. Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors. Circ J. 73:361-370,2009.PDF
  11. Saga A, Karibe A, Otomo J, Iwabuchi K, Takahashi T, Kanno H, Kikuchi J, Keitoku M, Shinozaki T, Shimokawa H. Lamin A/C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia. Tohoku J Exp Med. 218:309-316,2009.PDF
  12. Satoh K, Fukumoto Y, Nakano M, Sugimura K, Nawata J, Demachi J, Karibe A, Kagaya Y, Ishii N, Sugamura K, Shimokawa H. Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1. Cardiovasc Res. 81:226-234,2009.PDF
  13. Shiroto T, Yasuda S, Tsuburaya R, Ito Y, Takahashi J, Ito K, Ishibashi-Ueda H, Shimokawa H. Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo. J Am Coll Cardiol. 54:2321-2329,2009.PDF
  14. Sugai Y, Miura M, Hirose M, Wakayama Y, Endo H, Nishio T, Watanabe J, ter Keur HEDJ, Shirato K, Shimokawa H. Contribution of Na+/Ca2+ exchange current to the formation of delayed afterdepolarizations in intact rat ventricular muscle. J Cardiovasc Pharmacol. 53:517-522,2009.PubMed
  15. Suzuki H, Watanabe S, Hamaguchi T, Mine H, Terui T, Kanazawa M, Oohisa N, Maruyama M, Yambe T, Itoh M, Fukudo S. Brain activation associated with changes in heart rate, heart rate variability, and plasma catecholamines during rectal distention. Psychosomatic Med. 71:619-626,2009.PubMed
  16. Takagi Y, Yasuda S, Takahashi J, Takeda M, Nakayama M, Ito K, Hirose M, Wakayama Y, Fukuda K, Shimokawa H. Importance of dual induction tests for coronary vasospasm and ventricular fibrillation in patients surviving out-of-hospital cardiac arrest. Circ J. 73:767-769,2009.PDF
  17. Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, Terasaki T, Goto J, Ito S, Hishinuma T, Rubera I, Tauc M, Fujii-Kuriyama Y, Yabuuchi H, Moriyama Y, Soga T, Abe T. SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol. 20:2546-2555,2009.PDF

研究業績一覧へ |このページのTOPへ

2008年
  1. Anegawa G, Kawanaka H, Yoshida D, Konishi K, Yamaguchi S, Kinjyo N, Taketomi A, Hashizume M, Shimokawa H, Maehara Y. Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis. Hepatology. 47:966-977,2008.PDF
  2. Ashino T, Yamanaka R, Yamamoto M, Shimokawa H, Sekikawa K, Iwakura Y, Shioda S, Numazawa S, Yoshida T. Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages. Mol Immunol. 45:2106-2115,2008.PDF
  3. Fukui S, Fukumoto Y, Suzuki J, Saji K, Nawata J, Tawara S, Shinozaki T, Kagaya Y, Shimokawa H. Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats. J Cardiovasc Pharmacol. 51:317-326,2008.PubMed
  4. Fukumoto Y, Yasuda S, Ito A, Shimokawa H. Prognostic effects of benidipine in patients with vasospastic angina: comparison with diltiazem and amlodipine. J Cardiovasc Pharmacol. 51:253-257,2008.PubMed
  5. Ichinose A, Otani H, Oikawa M, Takase K, Saito H, Shimokawa H, Takahashi S. MRI of cardiac sarcoidosis: basal and subepicardial localization of myocardial lesions and their effect on left ventricular function. Am J Roentgenol. 191:862-869,2008.PDF
  6. Ikuta K, Mori T, Yamamoto T, Niidome T, Shimokawa H, Katayama Y. Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction. Bioorganic Med Chem. 16;2811-2818,2008.PDF
  7. Kishi T, Hirooka Y, Shimokawa H, Takeshita A, Sunagawa K. Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. Clin Exp Hypertens. 30:3-11,2008.PubMed
  8. Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, Mochizuki Y, Enaida H, Goto Y, Shimokawa H, Ishibashi T. Role of TGF-β in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Nat'l Acad Sci USA. 105:17504-17509,2008.PDF
  9. Kumagai K, Fukuda K, Wakayama Y, Sugai K, Hirose M, Yamaguchi N, Takase K, Yamauchi Y, Takahashi A, Aonuma K, Shimokawa H. Electrocardiographic characteristics of the variants of idiopathic left ventricular outflow tract ventricular tachyarrhythmias. J Cardiovasc Electrophysiol. 19:495-501,2008.PDF
  10. Miura M, Wakayama Y, Endoh H, Nakano M, Sugai Y, Hirose M, ter Keurs HEDJ, Shimokawa H. Spatial non-uniformity of excitation-contraction coupling can enhance arrhythmogenic delayed afterdepolarizations in rat cardiac muscle. Cardiovasc Res. 80:55-61,2008.PDF
  11. Nakata S, Tsutsui M, Shimokawa H, Morishita T, Sabanai K, Nagasaki M, Tanimoto A, Yatera Y, Tasaki H, Nakamura T, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N. Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation. 17:2211-2223,2008.PDF
  12. Oi K, Fukumoto Y, Ito K, Uwatoku T, Abe K, Hizume T, Shimokawa H. Extracorporeal shock wave therapy ameliorates hind-limb ischemia in rabbits. Tohoku J Exp Med. 214:151-158,2008.PDF
  13. Okimoto H, Ishigaki Y, Koiwa Y, Hinokio Y, Ogihara T, Suzuki S, Katagiri H, Ohkubo T, Hasegawa H, Kanai H, Oka Y. A novel method for evaluating human carotid artery elasticity: Possible detection of early stage atherosclerosis in subjects with type 2 diabetes. Atherosclerosis. 196:391-397,2008.PDF
  14. Onoue N, Nawata J, Tada T, Zhulanqiqige D, Wang H, Sugimura K, Fukumoto Y, Shirato K, Shimokawa H. Increased static pressure promotes migration of vascular smooth muscle cells: Involvement of the Rho-kinase pathway. J Cardiovasc Pharmacol. 51:55-61,2008.PubMed
  15. Sabanai K, Tsutsui M, Shimokawa H. Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system. J Bone Mineral Res. 23:633-643,2008.PDF
  16. Shiba N, Matsuki M, Takahashi J, Tada T, Watanabe J, Shimokawa H. Prognostic importance of chronic kidney disease in Japanese patients with chronic heart failure. Circ J. 72:173-178,2008.PDF
  17. Shiba N, Nochioka K, Kohno H, Matsuki M, Takahashi J, Tada T, Kagaya Y, Shimokawa H. Emerging problems of heart failure practice in Japanese women: lessons from the CHART study. Circ J. 72:2009-2014,2008.PDF
  18. Shimokawa H. Bone marrow-derived matrix metalloproteinase-14: A novel target for plaque stability. Circulation. 117:863-865,2008.PDF
  19. Tada T, Nawata J, Wang H, Onoue N, Zhulanqiqige D, Ito K, Sugimura K, Fukumoto Y, Shimokawa H. Enhanced pulsatile pressure accelerates vascular smooth muscle migration. -Implications for atherogenesis of hypertension- Cardiovasc Res. 80:346-353,2008.PDF
  20. Tada T, Shiba N, Watanabe J, Kagaya Y, Shinozaki T, Shirato K, Shimokawa H. Prognositc value of anemia in predicting sudden death of patients with diastolic heart failure. Int'l J Cardiol. 128:419-421,2008.PDF
  21. Takaki A, Morikawa K, Murayama Y, Tekes E, Yamagishi H, Ohashi J, Tsutsui M, Yanagihara N, Yada T, Shimokawa H. Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. J Exp Med. 205:2053-2063,2008.PDF
  22. Takaki A, Morikawa K, Murayama Y, Yamagishi H, Hosoya M, Ohashi J, Shimokawa H. Roles of endothelial oxidases in endothelium-derived hyperpolarizing factor responses in mice. J Cardiovasc Pharmacol. 52:510-517,2008.PubMed
  23. Takeno M, Yasuda S, Otsuka Y, Morii I, Kawamura A, Yano K, Miyazaki S. Impact of metabolic syndrome on the long-term survival of patients with acute myocardial infarction. Circ J. 72:415-419,2008.PDF
  24. Ulrich M, Petre A, Youhnovski N, Promm F, Schirle M, Schumm M, Pero RS, Doyle A, Checkel J, Kita H, Thiyagarajan N, Acharya KR, Schmid-Grendelmeier PS, Simon HU, Schwart H, Tsutsui M, Shimokawa H, Bellon G, Lee J, Przybyski M, Doring G. Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. J Biol Chem. 283:28629-28640,2008.PDF
  25. Yamaguchi N, Kumagai K, Fukuda K, Wakayama Y, Sugai Y, Hirose M, Shimokawa H. Electrophysiological properties of the right atrial septum in patients with atrial tachyarrhythmias. Tohoku J Exp Med. 215:13-22,2008.PDF

研究業績一覧へ |このページのTOPへ

2007年
  1. Asaumi Y, Kagaya Y, Takeda M, Yamaguchi N, Tada H, Ito K, Ohta J, Shiroto T, Shirato K, Minegishi N, Shimokawa H. Protective role of endogenous erythropoietin system in nonhematopoietic cells against pressure overload-induced left ventricular dysfunction in mice. Circulation. 115:2022-2032,2007.PDF
  2. Chida K, Fuda K, Kagaya Y, Saito H, Takai Y, Kohzuki M, Takahashi S, Yamada S, Zuguchi M. Influence of the target vessel on the location and area of maximum skin dose during percutaneous coronary intervention. Acta Radiol. 48:846-850,2007.PubMed
  3. Chida K, Kagaya Y, Saito H, Takai Y, Yamada S, Takahashi S, Zuguchi M. Total entrance skin dose: an effective indicator of maximum radiation dose to the skin during percutaneous coronary intervention. Am J Roentgenol. 189:224-227,2007.PDF
  4. Fukumoto Y, Kishi T, Tsutsui H, Yamada A, Okamatsu S, Takeshita A. Elevated serum C-reactive protein levels as a predictive indicator for subsequent renal impairment in patients with acute heart failure. Tohoku J Exp Med. 213:361-368,2007.PDF
  5. Fukumoto Y, Mohri M, Inokuchi K, Ito A, Hirakawa Y, Masumoto A, Hirooka Y, Takeshita A, Shimokawa H. Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina. J Cardiovasc Pharmacol. 49:117-121,2007.PubMed
  6. Hirasawa H, Tanaka S, Sakai A, Tsutsui M, Shimokawa H, Miyata H, Moriwaki S, Niida S, Ito M, Nakamura T. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. Bone Mineral Res. 22:1020-1030,2007.PDF
  7. Jiang BH, Tawara S, Abe K, Takaki A, Fukumoto Y, Shimokawa H. Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol. 49:85-89,2007.PubMed
  8. Kataoka Y, Nakatani S, Tanaka N, Kanzaki H, Yasuda S, Morii I, Kawamura A, Miyazaki S, Kitakaze M. Role of transthoracic Doppler-determined coronary flow reserve in patients with chest pain. Circ J. 71:891-896,2007.PDF
  9. Kita T, Hata Y, Kano K, Miura M, Nakao S, Noda Y, Shimokawa H, Ishibashi T. Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor. Diabetes. 56:231-238,2007.PDF
  10. Kokusho Y, Komaru T, Takeda S, Takahashi K, Koshida R, Shirato K, Shimokawa H. Hydrogen peroxide derived from beating heart mediates coronary microvascular dilation during tachycardia. Arterioscler Thromb Vasc Biol. 27:1057-1063,2007.PDF
  11. Minatoya Y, Ito K, Kagaya Y, Asaumi Y, Takeda M, Nakayama M, Takahashi J, Iguchi A, Shirato K, Shimokawa H. Depressed contractile reserve and impaired calcium handling of cardiac myocytes from chronically unloaded hearts are ameliorated with the administration of physiological treatment dose of T3 in rats. Acta Physiol. 189:221-231,2007.PDF
  12. Nakano M, Satoh K, Fukumoto Y, Ito Y, Kagaya Y, Ishii N, Sugamura K, Shimokawa H. Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice. Circ Res. 100:662-669,2007.PDF
  13. Nakata S, Tsutsui M, Shimokawa H, Yamashita T, Tanimoto A, Tasaki H, Ozumi K, Sabanai K, Morishita T, Suda O, Hirano H, Sasaguri Y, Nakashima Y, Yanagihara N. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway. Arterioscler Thromb Vasc Biol. 27:92-98,2007. PDF
  14. Saji K, Fukumoto Y, Suzuki J, Fukui S, Nawata J, Shimokawa H. Colchicine, a microtubule depolymerizing agent, inhibits myocardial apoptosis in rats. Tohoku J Exp Med. 213:139-148,2007.PDF
  15. Tada T, Shiba N, Watanabe J, Kagaya Y, Shinozaki T, Shirato K, Shimokawa H. Prognostic value of anemia in predicting sudden death of patients with diastolic heart failure. Int'l J Cardiol. in press, 2007.PDF
  16. Tamada T, Nara M, Kanatsuka H, Koshida R, Nagaoka M, Tamura G, Hattori T. A potentiating effect of endogenous NO in the physiologic secretion from airway submucosal glands. Am J Respir Cell Mol Biol. 37:357-365,2007.PDF
  17. Tawara S, Fukumoto Y, Shimokawa H. Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats. J Cardiovasc Pharmacol. 50:195-200,2007.PubMed
  18. Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K, Shimokawa H. Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. Coronary Art Dis. 18:397-404,2007.PubMed
  19. Yamawaki T, Yamada A, Fukumoto Y, Kishi T, Sobashima A, Kuwata K, Nakamura R, Sekiya M, Ando H, Okamatsu S. Statin therapy may prevent restenosis after successful coronary intervention, independent of lipid-lowering effect and CRP level. Fukuoka Igaku Zasshi. 98:260-269,2007.PubMed
  20. Yada T, Shimokawa H, Hiramatsu O, Shinozaki Y, Mori H, Goto M, Ogasawara Y, Kajiya F. Important role of endogenous hydrogen peroxide in pacing-induced metabolic coronary vasodilation in dogs in vivo. J Am Coll Cardiol. 50:1272-1278,2007.PDF
  21. Yada T, Shimokawa H, Morikawa K, Takaki A, Shinozaki Y, Mori H, Goto M,Ogasawara Y, Kajiya F. Role of Cu,Zn-SOD in the synthesis of endogenous hydrogen peroxide during reactive hyperemia in mouse mesentetric microcirculation in vivo. Am J Physiol. 294:441-448,2007.PDF
  22. Yasuda S, Ikuta K, Uwatoku T, Oi K, Abe K, Hyodo F, Yoshimitsu K, Sugimura K, Utsumi H, Katayama Y, Shimokawa H. In vivo magnetic resonance imaging of atherosclerotic lesions with a newly developed Evans blue-DTPA-gadolinium contrast medium in apolipoprotein-E-deficient mice. J Vasc Res. 45:123-128,2007.PDF
  23. Yasuda S, Miyazaki S, Kinoshita H, Nagaya N, Kanda M, Goto Y, Nonogi H. Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction. Clin Sci. 112:43-49,2007.PDF

研究業績一覧へ |このページのTOPへ

2006年
  1. Abe K, Tawara S, Oi K, Hizume T, Uwatoku T, Fukumoto Y, Kaibuchi K, Shimokawa H. Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. J Cardiovasc Pharmacol. 48:280-285,2006.PubMed
  2. Chapados R, Abe K, Elliot J, Ihida-Stunbery K, McKean D, Gates AT, Kern M, Merklinger S, Plant A, Shimokawa H, Jones PL. ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling. Circ Res. 99:837-844,2006.PDF
  3. Chida K, Otani H, Kohzuki M, Saito H, Kagaya Y, Takai Y, Takahashi S, Yamada S, Zuguchi M. The relationship between plasma BNP level and the myocardial phosphocreatine/adenosine triphosphate ratio determined by phosphorus-31 magnetic resonance spectroscopy in patients with dilated cardiomyopathy. Cardiology. 106:132-136,2006.PDF
  4. Chida K, Saito H, Kagaya Y, Kohzuki M, Takai Y, Takahashi S, Yamada S, Zuguchi M. Indicators of the maximum radiation dose to the skin during percutaneous coronary intervention in different target vessels. Catheter Cardiovasc Interv. 68:236-241,2006.PDF
  5. Endo H, Miura M, Hirose M, Takahashi J, Nakano M, Wakayama Y, Sugai Y, Kagaya Y, Watanabe J, Shirato K, Shimokawa H. Reduced inotropic effect of nifekalant in failing hearts in rats. J Pharmacol Exp Ther. 318:1102-1107,2006.PDF
  6. Fukumoto Y, Ito A, Takeshita A, Sunagawa K, Shimokawa H. Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease. Coronary Art Dis. 17:63-70,2006.PubMed
  7. Furuyama T, Komori K, Shimokawa H, Matsumoto Y, Uwatoku T, Hirano K, Maehara Y. Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits. J Vasc Surg. 43:1249-1256,2006.PDF
  8. Hizume T, Morikawa K, Takaki A, Abe K, Sunagawa K, Amano M, Kaibuchi K, Kubo C, Shimokawa H. Sustained elevation of serum cortisol level causes sensitization of coronary vasoconstricting responses in pigs in vivo - A possible link between stress and coronary vasospasm -. Circ Res. 99:767-775,2006.PDF
  9. Kumagai K, Takahashi A, Yamauchi Y, Aonuma K. Ventricular tachycardia originating from the epicardium identified by intracoronary mapping using a PTCA guidewire. J Cardiovasc Electrophysiol. 17:670-673,2006.PDF
  10. Kumagai K, Suzuki F, Aonuma K, Shimokawa H. Atrial tachycardia originating from the upper left atrial septum: demonstration of transseptal interatrial conduction using the infolded atrial walls. J Cardiovasc Electrophysiol. 17:907-911,2006.PDF
  11. Kunii S, Sugawara J, Kimura Y, Imai N, Chisaka H, Hasegawa H, Koiwa Y, Kanai H, Okamura K. Fetal myocardial thickening measured by ultrasonic-based technique called 'phased-tracking method'. Fetal Diagn Ther. 21:458-465,2006.PDF
  12. Miura M, Hata Y, Hiratyama K, Kita T, Noda Y, Fujisawa K, Shimokawa H, Ishibashi T. Critical role of the Rho-kinase pathway in TGF-β2-dependent collagen gel contraction by retinal pigment epithelial cells. Exp Eye Res. 82:849-859,2006.PDF
  13. Ohashi J, Yasuda S, Miyazaki S, Shimizu S, Morii I, Kurita T, Kawamura A, Kamakura S, Nonogi N. Prevention of life-threatening ventricular tachyarrhythmia by a novel and pure class-III agent, nifekalant hydrochloride. J Cardiovasc Pharmacol. 48:274-279,2006.PubMed
  14. Peridsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 107:4770-4780,2006.PDF
  15. Sadamatsu K, Shimokawa H, Tashiro H, Seto T, Yamamoto K. Different effects of simvastatin and losartan on cytokine levels in coronary artery disease. Am J Cardiovasc Drugs. 6:169-175,2006.PubMed
  16. Satoh K, Kagaya Y, Nakano M, Ito Y, Ohta J, Tada H, Karibe A, Minegishi N, Suzuki N, Yamamoto M, Ono M, Watanabe J, Shirao K, Ishii N, Sugamura K, Shimokawa H. Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice. Circulation. 113:1442-1450,2006.PDF
  17. Sun X, Minohara M, Kikuchi H, Ishizu T, Tanaka M, Piao H, Osoegawa M, Ohyagi Y, Shimokawa H, Kira J. The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. J Neuroimmunol. 180:126-134,2006.PDF
  18. Tada H, Kagaya K, Takeda M, Ohta J, Asaumi Y, Satoh K, Ito K, Karibe A, Shirato K, Minegishi N, Shimokawa H. Endogenous erythropoietin system in non-hematopoietic lineage cells plays a protective role in myocardial ischemia/reperfusion. Cardiovasc Res. 71:466-477,2006.PDF
  19. Takahashi K, Komaru T, Takeda S, Takeda M, Koshida R, Nakayama M, Kokusyo Y, Kawakami Y, Yamaguchi N, Miyazawa T, Shimokawa H, Shirato Y. gamma-tocopherol, but not alpha-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats. J Mol Cell Cardiol. 41:544-554,2006.PDF
  20. Tatsumi R, Yamada M, Katsuki Y, Okamoto S, Ishizaki J, Mizunoya W, Ikeuchi Y, Hattori A, Shimokawa H, Allen RE. Low-pH preparation of skeletal muscle satellite cells can be used to study activation in vitro. Int'l J Biochem Cell Biol. 38:1678-1685,2006.PDF
  21. ter Keurs HE, Wakayama Y, Sugai Y, Price G, Y Kagaya, Boyden PA, Miura M, Stuyvers BD. Role of sarcomere mechanics and Ca2+ overload in Ca2+ waves and arrhythmias in rat cardiac muscle. Ann NY Acad Sci. 1080:248-267,2006.PDF
  22. ter Keurs HE, Wakayama Y, Miura M, Shinozaki T, Stuyvers BD, Boyden PA, Landesberg A. Arrhythmogenic Ca2+ release from cardiac myofilaments. Prog Biophys Mol Biol. 90:1-3,151-171,2006.PDF
  23. Watanabe J, Shinozaki T, Shiba N, Fukahori K, Koseki Y, Karibe A, Sakuma M, Miura M, Kagaya Y, Shirato K. Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure. Eur J Heart Fail. 8:237-242,2006.PDF
  24. Yada T, Shimokawa H, Hiramatsu O, Shinozaki Y, Mori H, Kiyooka T, Goto M, Ogasawara Y, Kajiya F. Cardioprotective role of endogenous hydrogen peroxide during ischemia-reperfusion injury in canine coronary microcirculation in vivo. Am J Physiol. 291:1138-1146,2006.PDF
  25. Yada T, Shimokawa H, Kajiya F. Cardioprotective effect of hydroxyfasudil as a specific Rho-kinase inhibitor, on ischemia-reperfusion injury in canine coronary microvessels in vivo. Clin Hemorheol Microcirc. 34:177-183,2006.PubMed
  26. Yamada M, Tatsumi R, Kikuiri T, Okamoto S, Nonoshita S, Mizunoya W, Ikeuchi Y, Shimokawa H, Sunagawa K, Allen RE. Matrix metalloproteinases are involved in mechanical stretch-induced activation of skeletal muscle satellite cells. Muscle and Nerve. 34:313-319,2006.PubMed
  27. Yamagish T, Kato M, Koiwa Y, Hasegawa H, Kanai H. Usefulness of the measurement of carotid arterial wall elasticitys distribution in detection of early-stage atherosclerotic lesion by cigarette smoking. J Med Ultrasonics. 33:203-210,2006.PDF
  28. Yasuda S, Miyazaki S, Kanda M, Goto Y, Suzuki M, Harano Y, Nonogi H. Intensive treatment of risk factors in patients with type-2 diabetes mellitus is associated with improvement of endothelial function coupled with a reduction in the levels of plasma asymmetric dimethylarginine and endogenous inhibitor of nitric oxide synthase. Eur Heart J. 27:1159-1165,2006.PDF

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2005年
  1. Asaumi Y, Yasuda Y, Morii I, Kakuchi H, Otsuka Y, Kawamura A, Sasako Y, Nakatani T, Nonogi H, Miyazaki S. Favourable clinical outcome in patients with cardiogenic shock due to fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenetion. Eur Heart J. 26:2185-2192,2005.PDF
  2. Chida K, Otani H, Saito H, Nagasaka T, Kagaya Y, Kohzuki M, Zuguchi M, Shirato K. Feasibility of rapid-sequence 31P magnetic resonance spectroscopy in cardiac patients. Acta Radiol. 46:386-390,2005.PubMed
  3. Eto Y, Shimokawa H, Fukumoto Y, Matsumoto Y, Morishige K, Kunihiro I, Kandabashi T, Takeshita A. Combination therapy with cerivastatin and nifedipine improves endothelial dysfunction after balloon injury in porcine coronary arteries. J Cardiovasc Pharmacol. 46:1-6,2005.PDF
  4. Hedjazifar S, Jenndahl LE, Shimokawa H, Baeckstro¨m D. PKB mediates c-erbB2-induced epithelial β1 integrin conformational inactivation through Rho-independent F-actin rearrangements. Exp Cell Res. 307:259-275,2005.PDF
  5. Ito K, Hirooka Y, Hori N, Kimura Y, Sagara Y, Shimokawa H, Takeshita A, Sunagawa K. Inhibition of Rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats. Hypertension. 46:360-365,2005.PDF
  6. Katoh H, Shinozaki T, Baba S, Satoh S, Kagaya Y, Watanabe J, Shirato K. Monophasic action potential duration at the crista terminalis in patients with sinus node disease. Circ J. 69:1361-1367,2005.PDF
  7. Kozai T, Eto M, Matter C, Young Z, Shimokawa H, Luscher T. Stains prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway. Cardiovasc Res. 68:475-482,2005.PDF
  8. Kumagai K, Yamauchi Y, Takahashi A. Idiopathic left ventricular tachycardia originating from the mitral annulus. J Cardiovasc Electrophysiol. 16:1029-1036,2005.PDF
  9. Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang K-Y, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Nat'l Acad Sci USA. 102:10616-10621,2005.PDF
  10. Nakata S, Tsutsui M, Shimokawa H, Tamura M, Tasaki H, Morishita T, Suda O, Ueno S, Toyohira Y, Nakashima Y, Yanagihara N. Vascular neuronal NO synthase is selectively upregulated by platelet-derived growth factor. Involvement of the MEK/ERK pathway. Arterioscler Thromb Vasc Biol. 25:2502-2508,2005.PDF
  11. Oikawa M, Kagaya Y, Otani H, Sakuma M, Demachi J, Suzuki J, Takahashi T, Nawata J, Ido T, Watanabe J, Shirato K. Increased [F-18] fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. J Am Coll Cardiol. 45:1849-1855,2005.PDF
  12. Otani H, Kagaya Y, Imahori Y, Yasuda S, Fujii R, Chida M, Namiuchi S, Takeda M, Sakuma M, Watanabe J, Ido T, Nonogi H, Shirato K. Myocardial 11C-diacylglycerol accumulation and left ventricular remodeling in patients after myocardial infarction. J Nucl Med. 65:553-559,2005.PDF
  13. Otomo J, Shigeo K, Shiba N, Karibe A, Shinozaki T, Yagi T, Naganuma H, Tazuka F, Miura M, Ito M, Watanabe J, Matsubara Y, Shirato K. Electrophysiological and histopatholical characteristics of progressive atrioventricular block accompanied by familial dilated cardiomyopathy caused by a novel mutation of lamin A/C gene. J Cardiovasc Electrophysiol. 16:137-145,2005.PDF
  14. Sakai K, Hirooka Y, Shigematsu H, Kishi T, Ito K, Shimokawa H, Takeshita A. Overexpression of eNOS in brain stem reduces enhanced sympathetic drive in mice with myocardial infarction. Am J Physiol. 289:H2159-2166,2005.PDF
  15. Shiba N, Watanabe J, Shinozaki T, Koseki Y, Sakuma M, Kagaya Y, Shirato K. Poor prognosis of Japanese patients with chronic heart failure following myocardial infarction-Comparison with nonischemic cardiomyopathy. Circ J. 69:143-149,2005.PDF
  16. Sun H, Fukumoto Y, Ito A, Shimokawa H, Sunagawa K. Coronary microvascular dysfunction in patients with microvascular angina: analysis by TIMI frame count. J Cardiovasc Pharmacol. 46:622-626,2005.PDF
  17. Takahashi K, Komaru T, Takeda S, Satoh K, Kanatsuka H, Shirato K. Nitric oxide inhibition unmasks ischemic myocardium-derived vasoconstrictor signals activating endothelin type A receptor of coronary microvessels. Am J Physiol: Heart Circ Physiol. 289:H85-H91,2005.PDF
  18. Watanabe J, Shinozaki T, Shiba N, Fukahori F, Koseki Y, Karibe A, Sakuma M, Miura M, Kagaya Y, Shirato K. Accumulation of risk markers predicts the incidence of sudden death in patients with chronic heart failure. Eur J Heart Fail. Epub Ahead of print: 237-242,2005.PDF
  19. Watanabe J, Shiba N, Shinozaki T, Koseki Y, Karibe A, Komaru T, Miura M, Fukuchi M, Fukahori K, Sakuma M, Kagaya Y, Shirato K. Prognostic value of brain natriuretic peptide combined with left ventricular dimensions in predicting sudden death of patients with chronic heart failure. J Cardiac Fail. 11:50-55,2005.PDF
  20. Yahagi H, Takeda M, Asaumi Y, Okumura K, Takahashi R, Ohta J, Tada H, Minatoya Y, Sakuma M, Watanabe J, Goto K, Shirato K, Kagaya Y. Differential regulation of diacylglycerol kinase isozymes in cardiac hypertrophy. Biochem Biophys Res Commun. 332:101-108,2005.PDF

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